Biopesticide

ABSTRACT

A nucleopolyhedrovirus (NPV), a composition comprising the NPV, and a method comprising the use of the NPV is provided. The NPV was isolated from Cryptophlebia peltastica and has insecticidal activity against several species of moths within the tortricid tribe, Grapholitini. The NPV or composition may be suitable for use in controlling insect populations, particularly populations of insects that infest plants.

CROSS-REFERENCE TO RELATED APPLICATION

This application claims priority from South African provisional patent application number 2016/05197 filed on 26 Jul. 2016, which is incorporated by reference herein.

FIELD OF THE INVENTION

This invention relates to a biopesticide, more particularly a nucleopolyhedrovirus (NPV), for use in controlling insect populations.

BACKGROUND TO THE INVENTION

Chemical pesticides are the most commonly used agents for controlling insect pests in agriculture and forestry. Chemical insecticides may have adverse impacts not only on their target organisms but also on beneficial insects, such as bees and other pollinators. Accumulation of chemical pesticides through the food chain of an ecosystem has also been shown to have an adverse effect on birds and other insect predators. Furthermore, residues of chemical pesticides on fruit, vegetables and nuts may cause health problems among the human population.

Concerns over the use of chemical pesticides have led to an increased interest in biological pesticides. Insect baculoviruses are one group of insect biopesticides that have been promoted as an alternative control agent to chemical pesticides. These viruses, which can be isolated from a variety of insect species, exhibit relatively narrow host ranges and have almost no adverse environmental impact due to their host specificity. The absence of chemical residues means that long-term environmental hazards and health concerns are reduced with biopesticides. However, there are several disadvantages to biopesticides, including cost of production, efficacy and stability.

Nucleopolyhedrovirus (NPV) or alphabaculovirus is a genus of baculoviruses that infect insects, mostly moths and butterflies. NPVs have been known to be useful as biopesticides for insect-infested crops. NPVs have a high species specificity and while this enhances their utility as biopesticides, it may limit their effectiveness in cases of multiple pest infestation. Furthermore, there are isolated incidents of species of moth pests developing resistance to commercially-available strains of baculoviruses.

Cryptophlebia peltastica (also known as litchi moth) is a species of moth that is an important pest of litchi trees (Litchi chinensis) in Southern Africa, Mauritius and elsewhere. C. peltastica larvae are known to damage up to 20% of fruits in commercial orchards. This moth is also a pest of macadamia and a variety of other commercially significant trees and plants. There are currently no known biopesticides that specifically target C. peltastica and to date, no NPVs have been isolated from C. peltastica or from any other species within the same genus or the lepidopteran tribe Grapholitini.

There is therefore a need for a biopesticide which is active against Cryptophlebia peltastica and/or other insect pests.

SUMMARY OF THE INVENTION

In accordance with a first aspect of the invention, there is provided a nucleopolyhedrovirus (NPV) for use in controlling insect populations, the NPV having a genome sequence with at least 85% sequence identity to SEQ ID NO: 2.

The NPV may have a polyhedrin gene with more than 93% sequence identity to SEQ ID NO: 1.

The NPV may be an isolate or genotype of the species whose genome sequence is represented by SEQ ID NO: 2.

The NPV may have a virulence host range comprising the Grapholitini tribe of the lepidopteran family, Tortricidae, and the host range may include Cryptophlebia peltastica, Thaumatotibia leucotreta, Cydia pomonella, Grapholita molesta, and Thaumatotibia batracopa.

The insects may be selected from the tribe Grapholitini, particularly the larvae of Cryptophlebia peltastica, Thaumatotibia (Cryptophlebia) leucotreta and Cydia pomonella.

The NPV may be used in combination with one or more additional biopesticides, and the one or more additional biopesticide may be a Cryptophlebia leucotreta granulovirus, a Cydia pomonella granulovirus, a Cryptophlebia batracopa granulovirus or a Grapholita molesta granulovirus.

The NPV genome sequence may contain only one recognition site for the restriction enzyme Sma1.

In accordance with a second aspect of the invention, there is provided a biopesticidal composition comprising an NPV as described above and one or more agronomically acceptable adjuvants and/or diluents.

The composition may comprise an additional biopesticide, which may be a Cryptophlebia leucotreta granulovirus, a Cydia pomonella granulovirus, a Cryptophlebia batracopa granulovirus or a Grapholita molesta granulovirus. The composition may further comprise a feeding stimulant, a mineral oil and a UV protectant.

In accordance with a third aspect of the invention, there is provided a method of controlling insect populations, the method comprising applying to the insects and/or their locus an insecticidally effective amount of an NPV as described above or a biopesticidal composition as described above.

The method may comprise simultaneously or sequentially applying, in addition to the NPV or biopesticidal composition, at least one additional biopesticide to the insects and/or their locus.

In accordance with a fourth aspect of the invention, there is provided a method of treating or preventing insect infestations on plants or fruit, the method comprising applying an insecticidally effective amount of an NPV as described above or a biopesticidal composition as described above to the plants or fruit.

In accordance with a fifth aspect of the invention, there is provided an NPV isolated from Cryptophlebia peltastica, which has a genome sequence with at least 85% sequence identity to SEQ ID NO: 2.

The NPV may have a polyhedrin gene with more than 93% sequence identity to SEQ ID NO: 1.

BRIEF DESCRIPTION OF THE FIGURES

FIG. 1 illustrates transmission electron micrographs of NPV occlusion bodies (OBs) isolated from symptomatic C. peltastica larvae.

FIG. 2 illustrates a transmission electron micrograph of purified C. peltastica NPV OBs.

FIG. 3 illustrates transmission electron micrographs of OBs after sectioning of resin-embedded samples.

FIG. 4 illustrates a 0.7% agarose gel electrophoresis used to observe genomic DNA of C. peltastica NPV. Lane 1: GeneRuler 1 Kbp DNA Ladder (Thermo Scientific®), Lane 3: NPV genomic DNA.

FIG. 5 illustrates a 1% agarose gel electrophoresis showing PCR amplification of the polyhedrin gene of C. peltastica NPV. Lane 1: GeneRuler 1 Kbp DNA Ladder (Thermo Scientific®), Lane 3: negative control and Lane 5: ±700 bp positive control PCR product of concentrated CrleGV DNA, Lane 6: ±700 bp PCR product of 1:10 dilution of CrleGV DNA, Lane 8: concentrate DNA of C. peltastica NPV and Lane 9: 1:10 dilution of C. peltastica NPV DNA.

FIG. 6 is a Sma1 restriction profile comparing an in silico digest of C. peltastica NPV and a REN digest of C. peltastica NPV.

FIG. 7 is a graph illustrating the infectivity of C. peltastica NPV against three European codling moth cultures with varying degrees of resistance to Cydia pomonella granulovirus (CpGV): CpS (susceptible), CpRR1 (resistant) and Cp5M (more resistant).

DETAILED DESCRIPTION OF THE INVENTION

The invention provides a nucleopolyhedrovirus (NPV), also known as an alphabaculovirus, a biopesticidal composition comprising the NPV, and a method of controlling insect populations and infestations.

Throughout the specification, the term ‘plant’ is used in a general sense and is understood to refer to trees, shrubs and bushes, as well as the fruit, seeds and nuts of such trees, shrubs and bushes.

Moreover, the word ‘comprise’ or variations such as ‘comprises’ or ‘comprising’ is understood to imply the inclusion of a stated integer or group of integers but not the exclusion of any other integer or group of integers.

Furthermore, ‘insecticidally effective amount’ is understood to refer to those quantities of virus which will result in a significant mortality rate in a treated group of insect pests as compared to an untreated group.

The definition of a baculovirus species as herein described is understood to refer to all isolates and genotypes that have a K-2-P distance between single and/or concatenated polh, lef-8 and lef-9 nucleotide sequences which is smaller than 0.015. K-2-P is the Kimura 2-parameter distance (K), which is determined by the Kimura two parameter model according to the following formula:

K=−1/2ln((1−2p−q)√{square root over (1−2q)})

where p is the proportion of nucleotide sites that show transitional differences and q is the proportion of nucleotide sites that show transversional differences. Transitions refer to substitutions between nucleotide bases of the same type (purine for purine or pyrimidine for pyrimidine), whereas transversions refer to substitutions of a purine for a pyrimidine or a pyrimidine for a purine. Furthermore, two viruses are considered to be different virus species if the K-2-P distance between single and/or concatenated sequences is larger than 0.050. For distances between 0.015 and 0.050, complementary information is needed to determine whether two viruses are the same or different species. This definition is explained in further detail in Jehle et al Virology 346 (2006) 180-193.

The NPV was isolated from larvae of the Cryptophlebia peltastica moth in which it proliferates and to which it is pathogenic. The virus produces polyhedrin proteins that form occlusion bodies (OBs or polyhedra), which are globular structures that protect the virus particles from the outside environment until they are ingested by an insect host. The NPV is characterized by its genome sequence which has at least 85% sequence identity to SEQ ID NO: 2. The NPV has a characteristic polyhedrin gene that has a nucleotide sequence with at least 75% sequence identity to SEQ ID NO: 1, with the proviso that SEQ ID NO: 1 does not encode the Epinotia granitalis baculovirus polyhedrin gene.

In some embodiments the NPV can be characterized by its genome sequence which can have at at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity with SEQ ID NO: 2.

In further embodiments, the virus can have a polyhedrin gene with a sequence that has at least 80% sequence identity to SEQ ID NO: 1, and in further embodiments the virus can have a polyhedrin gene with at least 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% sequence identity with SEQ ID NO: 1. In some embodiments, the virus has a polyhedrin gene with a nucleotide sequence that has more than 93% sequence identity to SEQ ID NO: 1.

The NPV can be characterised in that it is an isolate or genotype of the NPV species whose genome sequence is represented by SEQ ID NO: 2.

The NPV may have a virulence host range that comprises the Grapholitini tribe of the lepidopteran family, Tortricidae. In particular, the NPV can have a virulence host range that includes members of the Grapholitini tribe selected from Cryptophlebia peltastica, Thaumatotibia leucotreta, Cydia pomonella, Grapholita molesta (oriental fruit moth), and Thaumatotibia batracopa (macadamia nut borer).

The nucleotide sequence of the NPV genome can have a characteristic single recognition site for the restriction enzyme, Sma1. This allows the NPV to be identified from other viruses that have more than one Sma1 recognition site.

The NPV can be applied in combination with one or more additional biopesticides, simultaneously, sequentially, or in a combined composition, in order to increase the spectrum of activity and to reduce the possibility of insect pests developing resistance to the virus. In particular, the NPV can be co-administered with another NPV or a betabaculovirus, also referred to as a granulovirus (GV), such as a Cryptophlebia leucotreta granulovirus, a Cydia pomonella granulovirus, a Cryptophlebia batracopa granulovirus or a Grapholita molesta granulovirus.

The NPV can be combined with one or more agronomically acceptable components, including adjuvants, diluents, surfactants, dispersing agents, emulsifiers, spreading agents and/or wetting agents to form a biopesticidal composition. The NPV can also be formulated to improve the stability or maintain the activity of the virus.

In particular, a composition comprising the NPV may additionally contain:

-   -   (i) one or more of the GVs referred to above;     -   (ii) one or more feeding stimulant selected from molasses,         sugar, syrup, alcohol sugars (such as mannitol and xylitol) and         Stevia leaf extract; and     -   (iii) one or more UV protectant.

In a preferred embodiment, the composition can be formulated to comprise molasses, mineral oil, and one or more of the UV protectant Break-Thru® OE446, Uvinil and clove oil. In this and other embodiments, the formulation can further comprise glycerine and distilled water.

The minimum effective concentration of the virus is 1 OB, which can be sufficient to kill 50% of first instar larvae in a treated sample.

The biopesticidal composition can be formulated to have a concentration of the NPV of from about 1×10³ to about 1×10¹⁵ viral occlusion bodies/ml. In some embodiments, the biopesticidal composition can have a concentration of the NPV of about 1×10¹⁰ viral OBs/ml.

A solution of the NPV can be produced on a commercial scale according to the following method. Jars containing cooked larval diet are placed into a biohazard chamber and sheets containing C. peltastica eggs each containing approximately 400 eggs are sterilized with formalin before being placed onto the diet in the rearing jars. The jars are then sealed. Approximately 80% of the rearing bottles containing 4^(th) and 5^(th) instar larvae are removed. The remaining 20% of the rearing bottles have their lids replaced with a cotton wool plug under the biohazard chamber and are left for a further ±8 d for the larvae to move out of the diet and begin pupation in the cotton wool substrate.

The pupated larvae are then removed from the jars and placed into containers containing approximately 10 mm of larval diet. Once the larvae cover the surface of the diet they are inoculated by spraying the surface of the diet with viral inoculum. The jars are then closed with a breathable lid and monitored. The diet and infected larvae are then harvested from the container after 7-8 days. The diet and harvested larvae are then homogenized in 4 litres of water per kilogram of diet and infected larvae (at pH 5.0), until the mixture appears uniformly smooth (approximately 20 min at 2400 rpm). The resulting liquid is sieved through a 100 micron nylon mesh into a clean container and re-homogenized after dilution with fresh water. The re-homogenized mixture is re-sieved and stored in cooling vats at 4° C. Storage bottles containing glycerol and distilled water are prepared before being filled with the virus suspension. The final product is stored at 4° C.

The biopesticidal composition can include one or more additional biopesticides, such as another NPV or GV. In some embodiments, the additional biopesticide is a Cryptophlebia leucotreta granulovirus, a Cydia pomonella granulovirus, a Cryptophlebia batracopa granulovirus or a Grapholita molesta granulovirus.

The NPV or composition is suitable for use as a biopesticide for controlling insect populations, particularly populations of moth and butterfly larvae of the tribe Grapholitini. Although isolated from C. peltastica, the virus also has activity against a range of other insect pests and can be used as a biopesticide for controlling Thaumatotibia leucotreta (false codling moth) and Cydia pomonella (codling moth) species. Thaumatotibia leucotreta is sometimes referred to as Cryptophlebia leucotreta and the two names can be used interchangeably. Furthermore, the virus can have activity against at least some strains of codling moth larvae that are resistant to Cydia pomonella granulovirus.

The NPV or composition can be applied to trees or plants as a biopesticide for treating or preventing insect infestations. Suitable examples include citrus (all varieties), grape (all varieties), peaches, plums, nectarines, apples, pears, walnuts, quinces, hazelnuts, pecans, macadamia, avocado, litchis, lychees, peppers, ornamentals, cotton, karalla, olives, grape vines, pepper bushes, pomegranates and persimmons.

The NPV or composition can be applied to the insects themselves and/or to the locus of the insects. For example, the NPV can be applied to the fruit, leaves, flowers and/or bark of the trees or plants which may be occupied or anticipated to be occupied by insect pests. In some embodiments, the NPV can be applied by spraying, although any suitable application method can be used.

The insecticidal activity or effectiveness of the NPV arises when an occlusion body (OB) of the virus is ingested by an insect host during feeding. Once inside the insect gut, the polyhedrin sac of the OB is solubilised by action of the alkaline digestive juices (pH 9.5 to 11.5) and by enzymatic degradation, which releases viral particles. Primary infection occurs in cells in the gut, followed by other cell types including haemocytes, tracheal cells, and fat cells. In advanced stages of viral infection, the cells contain multiple viral particles which are present in the nucleus. Eventually the nucleus and the cell rupture, liberating a plurality of viral OBs. The external appearance of infected larvae changes during viral infection. The larvae become sluggish and their growth is stunted. As infection progresses, the integument of the larvae may change colour. Eventually the integument ruptures and a greyish-white fluid is released containing multiple viral OBs. When healthy larvae feed on plant parts that have been contaminated with this fluid, they ingest the viral OBs and become infected themselves, leading to further propagation of the virus.

The invention will now be described in more detail by way of the following non-limiting examples.

EXAMPLES

Methods and Materials

A laboratory culture of C. peltastica was established at Rhodes University, Waainek research facility, South Africa. During rearing, larvae showing symptoms of ‘wilting’ disease were collected in microtubes and placed at −25° C. for future use. These symptoms were associated with colour change: milky pink appearance (early stage) and black/brown appearance (late stage).

In an attempt to isolate a baculovirus from the symptomatic larvae, a protocol for a granulovirus (GV) crude extract was adapted from Parnell et al. (2002). However, no virus was observed using this method and therefore an NPV protocol adapted from Grzywacz et al. (2007) was used instead. Insect cadavers were homogenised in 1 ml of 0.1% SDS in a microtube to disrupt the cuticle. The microtube was then vortexed for approximately 2 minutes. The homogenate was then centrifuged at 100×g for 10 to 20 seconds to remove insect debris. The supernatant was collected and placed into a separate microtube. The pellet was re-suspended in 1 ml 0.1% SDS and again centrifuged at 100×g for 10 to 20 seconds. The supernatant was pooled and the pellet discarded. The pooled supernatant was centrifuged at 2 500×g for 5 minutes to pellet the virus. The supernatant was discarded and the pellet was re-suspended in 1 ml ddH₂O and centrifuged at 2 500×g for 5 minutes. The supernatant was again discarded and the pellet re-suspended in approximately 100 to 200 μl ddH₂O.

Purification of Virus Occlusion Bodies by Glycerol Gradient Centrifugation

To distinguish the morphology of the baculovirus, occlusion bodies (OBs) were purified using a glycerol gradient. A 50 to 60% glycerol gradient was prepared in a microtube, following a method adapted from Grzywacz et al (2007), by placing 500 μl of 60% glycerol into a 2 ml tube overlaid with 500 μl of 50% glycerol. The pellet from a crude extract was re-suspended in 500 μl of 20% glycerol. 100 μl of this sample was then placed on top of the gradient and centrifuged at maximum speed for 15 minutes. Both the band and pellet were collected and re-suspended in 1 ml ddH₂O and centrifuged at maximum (12 100×g) speed for 15 minutes. The supernatant was discarded and the pellet was re-suspended and centrifuged again as described above. The final pellet was re-suspended in ddH₂O.

Transmission Electron Microscopy (TEM)

A drop of the prepared sample (±2 μl) was placed on a Forvar carbon coated grid for 30 seconds. Filter paper was used to drain off the excess sample. A drop of uranyl acetate was then placed on the grid and left for 20 seconds. Filter paper was used to remove the excess stain and the grid was left overnight. The grid was observed using a Zeiss Libra 120 transmission electron microscope at 80 000 kV. The images were analysed using Mega View (G2) Olympus analyses software. The size, width and diameter of the OBs was determined by measuring 100 OBs from the images taken.

CTAB DNA Extraction

A CTAB DNA extraction protocol was adapted from Aspinall et al. (2002). Using 200 μl of crude/purified occlusion bodies extracted, 90 μl of 1M sodium carbonate (Na₂CO₃) was added and incubated at 37° C. for 30 minutes. 120 μl Tris-HCl (1M, pH 6.8), 90 μl of 10% SDS and 50 μl proteinase K (25 mg/ml) were added and samples incubated for a further 30 minutes at 37° C. 10 μl RNAse A (10 mg/ml) was then added and incubated for another 30 minutes at 37° C. The solution was then centrifuged at 12 100×g for 3 minutes. The supernatant was transferred to a new 1.5 ml tube and the pellet was discarded. 400 μl of warm CTAB buffer was then added to the supernatant and incubated at 70° C. for 60 minutes. 400 μl of 4° C. chloroform was added and the sample centrifuged at 6 500×g for 10 minutes. The upper phase was transferred into a new 1.5 ml tube and 400 μl of −25° C. isopropanol was added. The sample was then left overnight at −25° C. The sample was then centrifuged at 12 100×g for 20 minutes and the supernatant discarded. 1 ml of cold 70% ethanol was added to the pellet and the sample centrifuged at 12 100×g for 5 minutes. The supernatant was discarded and the pellet was incubated at 50° C., until dry. The pellet was re-suspended in 20 μl 10 mM Tris-HCl (pH 8.0).

Polymerase Chain Reaction (PCR)

Degenerate oligonucleotide primers, prPH-1 and prPH-2 designed by Lange et al. (2004) were used to genetically characterise the isolated NPV (Table 1). The primers were used to amplify the polyhedrin gene using DNA extracted from the purified OBs.

TABLE 1 Degenerate oligonucleotide primers for the partial amplification of the polH/gran gene region (Lange et al. 2004). Oligonucleotide name Sequence (5′ to 3′) Polh/gran TGTAAAACGACGGCCAGTNRCNGARGAYCCNTT (prPH-1) SEQ ID NO: 3 (Polh/gran CAGGAAACAGCTATGACCDGGNGCRAAYTCYTT (prPH-2) SEQ ID NO: 4 *N = C, A, T or G; R = A or G; Y = C or T; D = A, G or T

PCR reactions were set up for a positive control, negative control and C. peltastica NPV. The positive control consisted of DNA extracted from CrleGV (Cryptophlebia leucotreta granulovirus) to ensure correct amplification with the degenerate primers and the negative control contained no DNA to determine the presence of contamination. The DNA concentration for C. peltastica NPV was determined using a Nanodrop spectrophotometer (Thermo Scientific®) to be approximately 84 ng/μl. This was considered when mixing the reagents.

PCR parameters used for the amplification of the polyhedrin gene were adapted from Lange et al. (2004) in order to obtain a PCR product of the 507 to 510 nucleotides for analysis. The PCR amplification was performed in a thermocycler (BIO-RAD®). The PCR products were analysed by 1% AGE and band sizes estimated using GeneRuler 1 Kbp DNA Ladder (Thermo Scienticfic®) to confirm the presence and size of the virus gene.

Sequencing

The PCR products obtained were sequenced by Inqaba Biotechnology Industries (Pty) Ltd (South Africa). FinchTV® version 1.4.0 (Geospiza Inc. 2004-2006) was used to view the chromatograms in order to clean-up ambiguous nucleotides. Following the clean-up, sequences were subjected to NCBI BLAST to determine a closely matched baculovirus sequence. Sequences were analysed in MEGA® 6 (Tamura et al. 2013) to determine single nucleotide polymorphisms (SNPs). Once SNPs were determined, the sequences were translated to determine if the SNPs resulted in amino acid changes.

Results

Symptomology

Collection of symptomatic larvae from the culture began once the culture reached high densities. Symptomatic larvae were found randomly during rearing, in medium to low densities depending on how crowded the larvae were and the time the infected larvae were found. Symptomatic larvae were found on the surface of the diet, within the diet and hanging from the sides of the containers. Early symptoms of the virus were observed by a colour change in the insects, commonly from milky pink to brown-black. Once larvae had reached the brown/black stage they were prone to rupturing as the cuticle became soft and liquefied. Caution was therefore taken when these larvae were collected to avoid rupturing the cuticle.

Crude Baculovirus Extraction and Transmission Electron Microscopy

Transmission electron microscopy of a crude extract confirmed the presence of a baculovirus. The OBs were observed as amorphous black structures clumped together. The images of the OBs show the characteristic features of a NPV (FIG. 1). The OBs varied in size between 421 nm to 1263.2 nm. The mean size of 100 NPV OBs was found to be 731.09±15.13 nm.

Purification of Virus Occlusion Bodies by Glycerol Gradient Centrifugation

Glycerol gradient centrifugation was used to purify OBs from the crude extract. A band forming on top of the gradient and the pellet were collected and placed in separate microtubes. TEM was then completed on both samples. Very few to no OBs were observed in the band, with numerous pure OBs found in the pelleted sample.

The pelleted sample contained the majority of the NPV OBs. Even though the sample was found in the pellet where the insect debris is usually found, the sample was pure. OBs were observed and could be morphological characterised. As shown in FIG. 2 the varying sizes, circular shapes and clumping together of the NPV can be observed.

DNA Extraction Using NPV Genomic DNA

Genomic DNA was successfully extracted from C. peltastica NPV crude extract of OBs. The DNA was analysed on 0.7% agarose gel electrophoresis and found to be of high molecular weight (>10 000 bp) (FIG. 4).

PCR Amplification of the Polyhedrin Gene Using Degenerate Primers

Genomic DNA obtained was used to amplify the polyhedrin gene using degenerate primers. The amplified product was analysed on 1% agarose gel electrophoresis, illustrated in FIG. 5. There was no evidence of contamination as no band was present in the negative control (Lane 3). The positive control of CrleGV was successful as a ±700 base pair product was amplified (Lane 5 & 6). The polyhedrin gene of C. peltastica was successfully amplified, as evidenced by the obtained PCR product of approximately 700 base pairs (Lane 8 & 9). All products were of good quality, producing pure, tight bands.

Sequencing Analysis

Sequences obtained were subjected to a BLAST, using a blastn analysis where a closest match of 93% was observed with a partial sequence of Epinotia granitalis baculovirus polyhedrin gene region (501 nucleotides). After sequence clean-up the sequence for C. peltastica NPV polH was found to be 507 nucleotides in length (SEQ ID NO:1). Following translation and alignment between the two sequences, several SNPs were observed. Five of these SNPs resulted in amino acid changes: Isoleucine to Valine, Phenylalanine to Tyrosine, Serine to Alanine, Valine to Isoleucine and Glutamic acid to Aspartic acid. The remaining SNPs were minor and did not result in any changes.

E. granitalis, the cypress bark moth, is native to Japan and is a pest of Japanese cedar and Japanese cypress (Takatsuka 2007). There is limited research on E. granitalis baculovirus and only a partial polh/gran sequence is available for comparison. The reasons as to why the polyhedrin gene sequences of these viruses are so closely matched are unknown because they infect different insect species that are not found in the same geographic region and they do not share the same hosts.

This is the first identification of a NPV infecting C. peltastica and further characterisation through whole genome sequencing and REN analysis of genomic DNA was conducted to investigate the novel status of this virus.

Genomic Analysis of Cryptophlebia Peltastica Nucleopolyhedrovirus

Further genetic characterisation of the isolated NPV was carried out using restriction endonuclease (REN) analysis and sequencing of the full genome. REN analysis is a technique used extensively in molecular biology for genetic engineering, genome mapping and DNA sequence analysis (Roberts 1979; Bikandi et al. 2004). REN analysis is also an important technique that can be used to compare the genotypes of different virus isolates for biological control purposes.

Restriction endonuclease analysis is used to create a genetic ‘fingerprint’ for isolated viruses. In order to produce this ‘fingerprint’ viral DNA is digested with the use of restriction enzymes. These enzymes cut the DNA strands at certain nucleotide sequences, resulting in several pieces of DNA strands. The fragments are then analysed by agarose gel electrophoresis, which separates them according to size creating a DNA profile. It is from these ‘fingerprints’ that viral isolates can be characterised in terms of genotype.

Restriction Endonuclease Analysis

Genomic DNA was extracted and used to create REN profiles, using the following fast digest restriction enzymes BamH1, EcoR1, Hind111, Kpn1, Pst1, Sal1, Sma1, Xba1 and Xho1 (Thermo Scientific®, USA). A 30 μl reaction was set up, comprising of 200 ng/μl of template DNA, 3 μl fast digest restriction enzyme, 3 μl fast digest buffer and the remaining volume made up with ddH₂O. The reaction was incubated at 37° C. for 15 minutes. REN profiles were visualised using 0.6% agarose gel electrophoresis, which were electrophoresed at 30 volts for 16 hours in 1× TAE buffer and stained with ethidium bromide. Images of the REN profiles were captured using UVIpro chemi (UVItec) UV trans-illuminator. To determine the band sizes two DNA ladders were used, a GeneRuler high range ladder (Thermo Scientific®, USA) and GeneRuler 1 Kb DNA ladder (Thermo Scientific®, USA). UviBand software (UVItec) was used to estimate the band and genome sizes.

Restriction Endonuclease Analysis Profiles

None of the REN profiles of BamH1, EcoR1, Hind111, Kpn1, Pst1, Sal1, Xba1 and Xho1 produced a characteristic profile that could be used to easily distinguish CrpeNPV from similar baculoviruses. However, the REN profile produced by Sma1 digestion produced a characteristic profile containing a single band in the agarose gel electrophoresis gel (FIG. 6). This indicates that there is only one recognition site in the CrpeNPV genome for Sma1, which can be used as a simple means of analysis and identification of virus isolates.

As no other profiles of known CrpeNPV analogues were available for comparison, REN analysis could not be used to accurately characterise CrpeNPV. Therefore the whole genome was sequenced for a more accurate method of genetic characterisation.

Genome Sequencing

The full genome (SEQ ID NO:2) of CrpeNPV, using approximately 100 ng of DNA extracted from purified OBs, was sequenced by Inqaba Biotechnical Industries (Pty) Ltd (South Africa) using a MiSeq Desktop Sequencer (Illumina). The Illumina sequencing of the full genome of CrpeNPV produced a total of 3 871 946 paired reads. Geneious (New Zealand) version R7 (Kearse et al. 2012) was used to complete a de novo assembly. In order to produce a de novo assembly, the ends of the paired reads were trimmed using the soft trimming function in Geneious. Once the paired reads were trimmed a de novo assembly was run using 20% of the data and numerous contigs were produced. The longest contig was selected and a consensus sequence was generated to create a full genome sequence for CrpeNPV.

Analysis of the CrpeNPV Genome

A total of 3 871 946 paired reads were produced from the Illumina sequencing. Of these reads 760 297 were used to complete a de novo assembly, which produced 104 532 contigs. The largest contig, contig 1, was used to create a consensus sequence of 116 646 bp. The consensus sequence had a coverage of 731.6±390.8 (Mean±StDev) and a GC content of 37.1%. The full genome of CrpeNPV (SEQ ID NO: 2) was annotated using a database of 18 NPV full genome reference sequences. A total of 105 genes with complete coding regions (stop to start condons) were identified in the genome. The 105 genes were labelled according to ORF numbers, ORF1 starting at the polyhedrin gene.

The majority of the 31 core genes identified in all baculovirus genome were recognised in the CrpeNPV genome with the exception of gp64, p6.9, odvp-6e, p95, vp80/97, gp67, p87, lef-6, ptp-2, ptp-2, arif, vef, pcna, ie-2, lef-7, pe38 and lef-3. The gp64 gene is a distinguishing feature for NPVs, as NPVs are divided into two groups, group 1 and group 2. Group 1 NPVs express the gp64 gene and fusion protein, whereas group 2 NPVs lack the gp64 gene but contain the fusion protein. Therefore the CrpeNPV is a group 2 NPV since it lacks the gp64 gene.

The results of the BLAST search revealed that there are no known polyhedrin genes having a nucleotide sequence greater than 93% sequence identity to SEQ ID NO: 1 (the CrpeNPV polyhedrin gene sequence).

Biological Activity

The bioassays were used to determine the virulence of CrpeNPV against C. peltastica, T. leucotreta and C. pomonella using a surface dose bioassay method. The first objective of the bioassay study was to determine the concentration of the viral product required to cause 50% (LC₅₀) and 90% (LC₉₀) mortality by using a range of doses against all three species. The second objective was to determine the speed to kill 50% (LT₅₀) and 90% (LT₉₀) of the population using the LC₉₀ value obtained from the dose-response assays.

Surface Dose-Response Bioassays with C. peltastica Neonate Larvae

Surface dose bioassays were conducted in glass vials. Each glass vial was filled with 2 g of false codling moth (FCM) artificial diet and 2 ml of distilled water, the diet autoclaved at 121° C. for 13 minutes. Six five-fold dilutions of purified OBs of CrpeNPV in sterilised distilled water were used for doses and sterile distilled water as a control. Forty eight larvae were treated per dose (48 glass vials per dose) and assays were replicated three times. A volume of 100 μl of each viral dilution and control was pipetted onto the centre of the diet surface. The fluid was spread evenly over the diet surface by rotating the vial at an angle. Inoculated glass vials were left for ±30 mins, until the diet had dried. One neonate larva was placed into each vial. All larvae were from the same batch of eggs, hatching at the same time. Vials were then closed with a lid and left upside down for approximately twelve hours to prevent larvae from escaping. Vials were kept in a CE room at 27° C. and a relative humidity of 60-80%. Vials were then turned upright. Approximately 24 hours later, lids were replaced with cotton wool.

After 7 days, vials were opened and diet was inspected. Larvae were recorded as dead or alive. The dose-response curve was calculated using PROBAN (Van Ark 1995) software used for probit analysis (Finney 1971). Mortality of control larvae were taken into consideration by PROBAN and corrected using Abbott's formula (Abbott 1925). From the analysis, LC₅₀ and LC₉₀ were calculated for each replicate. An average LC₅₀ and LC₉₀ were obtained from the means from the three assays.

Surface Dose-Response Bioassays with FCM Neonate Larvae

Surface dose bioassays were conducted in 24 well plates. Diet was prepared by adding 250 g of FCM artificial diet to a pyrex dish, 300 ml of dH₂O was added to the diet. The diet was sterilised in an oven at 180° C. for 30 mins. Diet plugs were then cut out using a glass vial. Diet plugs were then pressed into the wells of the plate using a sterile glass rod. Six five-fold dilutions of purified OBs of CrpeNPV in sterilised distilled water were used for doses and sterile distilled water as a control. Forty eight larvae were treated per dose (two 24 well plates per dose) and assays were replicated three times. A volume of 50 μl of each viral dilution and control was pipetted onto the centre of the diet surface. The fluid was spread evenly over the diet surface by rotating the plates.

Inoculated plates were left for ±30 mins, until diet had dried. One neonate larva was placed into each well. All larvae were from the same batch of eggs, hatching at the same time. Assay plates were sealed with parafilm and kept in a CE room at 27° C. and a relative humidity of 60-80%.

After 7 days, plates were opened and diet was inspected. Larvae were recorded as dead or alive. The dose-response curve was calculated using PROBAN (Van Ark 1995) software used for probit analysis (Finney 1971). Mortality of control larvae were taken into consideration by PROBAN and corrected using Abbott's formula (Abbott 1925). From the analysis, LC₅₀ and LC₉₀ were calculated for each replicate. An average LC₅₀ and LC₉₀ were obtained from the means from the three assays.

Surface Dose-Response Bioassays with Codling Moth Neonate Larvae

Surface dose bioassays were conducted in 24 well plates. Diet was prepared by autoclaving 13 g of agar in 400 ml of distilled water. 235.27 g of pre-mixed bollworm diet was sterilised in an oven at 180° C. for 10 mins. A 1527 μl of propionic acid and 154 μl of phosphoric acid was mixed into the sterilised diet. Agar was then added to the diet, 200 to 400 ml of boiling water was added and mixed to form a uniform paste. Diet was then piped into the 24 well plates. Five five-fold dilutions of purified OBs of CrpeNPV in sterilised distilled water was used for doses and sterile distilled water as a control. Forty eight larvae were treated per dose (two 24 well plates per dose) and assays were replicated three times. A volume of 50 μl of each viral dilution and control was pipetted onto the centre of the diet surface. The fluid was spread evenly over the diet surface by rotating the plates. Inoculated plates were left for ±30 mins, until diet had dried. One neonate larva was placed into each well. All larvae were from the same batch of eggs, hatching at the same time. Wells were sealed with parafilm and kept in a CE room at 27° C. and a relative humidity of 60-80%.

After 7 days, plates were opened and diet was inspected. Larvae were recorded as dead or alive. The dose-response curve was calculated using PROBAN (Van Ark 1995) software used for probit analysis (Finney 1971). Mortality of control larvae were taken into consideration by PROBAN and corrected using Abbott's formula (Abbott 1925). From the analysis, LC₅₀ and LC₉₀ were calculated for each replicate. An average LC₅₀ and LC₉₀ were obtained from the means from the three assays.

Time-Response Bioassays

Time response bioassays were conducted in glass vials. Fifty glass vials were inoculated with 100 μl of sterile distilled water and 50 vials were inoculated with the LC₉₀ (calculated from the dose-response bioassays) solution of purified CrpeNPV. The diet was left for ±30 mins, until it had dried adequately. One neonate larva was placed into each vial. Vials were sealed with a lid and the same process repeated as above and kept in a CE room at 27° C. and a relative humidity of 60-80%. Bioassays were replicated three times. After 16 hours, the vials were inspected for dead larvae. Subsequently, vials were checked every 8 hours until mortality had ceased. Diet was then dissected to determine whether the remaining vials contained dead or alive larvae. Time-response was analysed using a logit regression in STATISTICA version V12 (StatSoft 2013). From the results obtained, the LT₅₀ and LT₉₀ were calculated.

Results of Surface Dose-Response Bioassays

The dose response curves for LC₅₀ and LC₉₀ were determined for each species and isolate. The results are presented in Table 2 below.

TABLE 2 Comparison of the mean LC₅₀ and LC₉₀ values for C. peltastica, T. leucotreta and C. pomonella (South African) and C. pomonella (European, with isolates CpS and CpRR1 being susceptible and resistant, respectively, to CpGV). DOSE RESPONSE (OBs/ml) CrpeNPV CrleGV CpGV C. peltastica LC₅₀ 8.19 × 10³ — — (Litchi Moth) LC₉₀ 3.33 × 10⁵ — — T. leucotreta LC₅₀ 2.29 × 10³ 4.095 × 10³ — (False Codling LC₉₀ 9.97 × 10⁴ 1.185 × 10⁵ — Moth) C. pomonella LC₅₀ 1.43 × 10³ — 1.632 × 10³ (South African LC₉₀ 1.26 × 10⁴ — 1.163 × 10⁵ Codling Moth) CpS LC₅₀ 2.70 × 10³ LC₉₀ 2.86 × 10⁴ CpRR1 LC₅₀ 3.64 × 10³ LC₉₀ 3.24 × 10⁴

The virulence of CrpeNPV against T. leucotreta and C. pomonella was slightly more fatal than that of their homologous baculoviruses, CrleGV and CpGV-SA. The LC₅₀ and LC₉₀ for CrleGV against its homologous host, T. leucotreta was found to be 4.095×10³ OBs/ml and 1.185×10⁵ OBs/ml respectively (Moore et al. 2011). The LC₅₀ and LC₉₀ for CpGV-SA against its homologous host, C. pomonella was found to be 1.632×10³ OBs/ml and 1.163×10⁵ OBs/ml respectively (Motsoeneng 2016).

TABLE 3 Comparison of LC₅₀ values for European C. pomonella isolates CpS, CpRR1 and Cp5M against isolates of CpGV. The CpS, CpRR1 and Cp5M isolates are susceptible, resistant, and more resistant, respectively, to CpGV. LC₅₀ (OBs/ml) for 14 days CpGV Isolates Cps CpRR1 Cp5M M 1.34 × 10² 4.46 × 10⁷ 1.88 × 10⁸ V015 9.94 × 10² 8.82 × 10² I07R 1.58 × 10³ 6.97 × 10³ 1.46 × 10⁷ I12 8.90 × 10² 1.40 × 10³ 7.76 × 10⁶ S 2.50 × 10³ 7.20 × 10² E2 9.50 × 10² 2.80 × 10² Madex Plus 5.26 × 10² 6.32 × 10⁶ CrpeNPV 8.39 × 10² 1.39 × 10³

The results illustrated in Table 3 demonstrate comparable activity of CrpeNPV against CpGV-sensitive and CpGV-resistant European codling moth isolates. M is a Mexican strain of CpGV; V015 is a resistance overcoming Mexican isolate of CpGV; I07R and I12 are Iranian isolates of CpGV; S is an isolate of CpGV isolated from the commercial product, Virosoft; E2 is an English isolate of CpGV; Madex Plus is a laboratory selected isolate from CpGV-resistant codling moth.

Results of Time-Response Bioassays

Speed to kill values LT₅₀ and LT₉₀ were determined for each species and are illustrated in Table 4 below.

C. peltastica had an LT₅₀ of 73.44 hours and LT₉₀ of 89.21 hours.

T. leucotreta had a LT₅₀ of 80.69 hours and LT₉₀ of 96.37 hours.

C. pomonella had a LT₅₀ of 106.09 and LT₉₀ of 125.52 hours.

TABLE 4 Comparison of the mean LT₅₀ and LT₉₀ values for C. peltastica, T. leucotreta and C. pomonella. TIME RESPONSE (at LC₉₀ dose) CrpeNPV CrleGV CpGV C. peltastica LT₅₀ 73.44 hours — — (Litchi Moth) LT₉₀ 89.21 hours — — T. leucotreta LT₅₀ 80.69 hours 118 hours — (False Codling LT₉₀ 96.37 hours 176 hours — Moth) C. pomonella LT₅₀ 106.09 hours  — 135 hours (Codling Moth) LT₉₀ 125.52 hours  — —

Speed to kill values LT₅₀ and LT₉₀ were also determined for two Cydia pomonella cultures and against four viral isolates, as illustrated in Table 5 below.

TABLE 5 Comparison of LT50 and LT90 values for two Cydia pomonella cultures; CpS (susceptible) and Cp5M (resistant) against four viral isolates; CpGV-S, CpGV-E2, CpGV-M and CrpeNPV. CpS CpR5M LT₅₀ LT₉₀ LT₅₀ LT₉₀ CpGV-S 139.28 183.55 — — CpGV-E2 107.68 132.07 126.89 156.48 CpGV-M 115.58 148.74 200.00 — CrpeNPV 120.34 147.49 110.92 135.18

The speed of kill for CrpeNPV against the heterologous hosts was greater than that of their homologous granuloviruses (Table 4). As the LT₅₀ and LT₉₀ for CrleGV against T. leucotreta was observed to be 118 hours and 176 hours (Moore et al. 2011) and a LT₅₀ of 135 hours for CpGV-SA against C. pomonella (Motsoeneng 2016).

From the above results it was established that CrpeNPV was more virulent against the neonate T. leucotreta and C. pomonella larvae, specifically with a significantly faster speed of kill for both species. The mean LC and LT values were slightly less than for their own homologous baculovirus, CrleGV and CpGV-SA.

Test for Infectivity

Two discriminating virus concentrations (5.8×10⁴ and 5.8×10⁵ OBs/ml) were used to test the infectivity of CrpeNPV against three European codling moth (C. pomonella) cultures with varying susceptibilities to Cydia pomonella granulosis virus (CpGV): CpS (susceptible), CpRR1 (resistant) and Cp5M (more resistant). CrpeNPV caused 100% mortality for all three cultures at 5.8×10⁴ and 5.8×10⁵ OBs/ml (see FIG. 7). Assays were also performed to determine the LC50 and LC90 values after seven and fourteen days incubation time and the results are presented in Tables 6 and 7 below.

TABLE 6 Comparison of the LC50 and LC90 values for the three European codling moth cultures: CpS, CpRR1 and CpR5M after seven days Dose (OBs/ml) CpS LC₅₀ 2.70 × 10³ LC₉₀ 2.86 × 10⁴ CpRR1 LC₅₀ 3.64 × 10³ LC₉₀ 3.24 × 10⁴ Cp5M LC₅₀ 2.19 × 10³ LC₉₀ 2.32 × 10⁴

TABLE 7 Comparison of the LC50 and LC90 values for the three European codling moth cultures: CpS, CpRR1 and CpR5M after fourteen days Dose (OBs/ml) CpS LC₅₀ 8.39 × 10² LC₉₀ 7.98 × 10³ CpRR1 LC₅₀ 1.39 × 10³ LC₉₀ 1.69 × 10⁴ Cp5M LC₅₀ 7.02 × 10² LC₉₀ 4.68 × 10³

These results indicate that CrpeNPV has activity against a wide host range including CpGV-resistant species of moth pests. This could be useful when multiple lepidopterans infest the same host because not only will the primary pest be controlled but also the secondary pests. The secondary pests are usually only observed once the primary pest has been suppressed.

The biological activity of CrpeNPV was found to be more virulent against the heterologous hosts including CpGV-resistant codling moth species with a faster speed of kill. These results indicate that CrpeNPV has the potential to be commercially developed into a biopesticide for controlling insect populations of C. peltastica, T. leucotreta and C. pomonella in trees and plants, particularly in fruit (e.g. litchi, citrus, apple and pear) and nut (e.g. macadamia and walnut) trees. Additionally, CrpeNPV could also be used to control other lepidopteran pests in the Tortricidae family.

TABLE 8 Nucleotide sequence of C. peltastica NPV poly- hedrin gene (polH)(SEQ ID NO: 1) ACTTACTTTGTTTAAAGAAATCCGTAGCGTTAAGCCCGACACAATGAAAC TAGTTGTTAATTGGAGCGGTAAAGAGTTTTTGAGGGAAACTTGGACTCGT TTCATGGAGGACAGCTTTCCCATTGTAAACGACCAAGAAATTATGGATGT TTTCCTAGTAGTTAACATGCGCCCGACTAGACCTAACCGTTGCTACAAGT TCTTGGCTCAACACGCTCTTCGTTGCGACCCAGACTATGTGCCTCACGAA GTAATTAGAATAGTTGAGCCGTCATGGGTGGGAAGCAACAACGAGTACCG TATTAGTCTGGCCAAGCGCGGCGGCGGATGTCCAGTGATGAATCTGCATG CTGAGTACACCAACTCGTTTGAAGAGTTCATTAACAGAGTCATTTGGGAA AACTTCTACAAGCCCATTGTGTACATTGGTACCGACTCTGCTGAGGAAGA GGAAATTCTAATGGAAGTTTCCCTGGTGTTCAAAGTAAAGGATTTCGCCC CGGGCCATACCTGTTTTTCGG

TABLE 9 Nucleotide sequence of the C. peltastica NPV genome (SEQ ID NO: 2) ATGTATACGCGTTACAGTTATAACCCATCTTTGGGTCGTACGTATGTTTATGACAACAAGTATTACAAAAACCTCGGCTCAGTA ATCAAAAACGCCAAACGTAAGCGCCACCTACTCGAGCATGAAATCGAGGAACGTAATTTGGACCCCCTAGATAATTATCTGGTC GCCGAGGATCCTTTCCTGGGACCCGGCAAAAACCAGAAACTTACTTTGTTTAAAGAAATCCGTAGCGTTAAGCCCGACACAATG AAACTAGTTGTTAATTGGAGCGGTAAAGAGTTTTTGAGGGAAACTTGGACTCGTTTCATGGAGGACAGCTTTCCCATTGTAAAC GACCAAGAAATTATGGATGTTTTCCTAGTAGTTAACATGCGCCCGACTAGACCTAACCGTTGCTACAAGTTCTTGGCTCAACAC GCTCTTCGTTGCGACCCAGACTATGTGCCTCACGAAGTAATTAGAATAGTTGAGCCGTCATGGGTGGGAAGCAACAACGAGTAC CGTATTAGTCTGGCCAAGCGCGGCGGCGGATGTCCAGTGATGAATCTGCATGCTGAGTACACCAACTCGTTTGAAGAGTTCATT AACAGAGTCATTTGGGAAAACTTCTACAAGCCCATTGTGTACATTGGTACCGACTCTGCTGAGGAAGAGGAAATTCTAATGGAA GTTTCCCTGGTGTTCAAAGTAAAGGAGTTTGCTCCTGATGCTCCTTTGTACACCGGACCAGCGTATTAAACAATAGATTGCGCA GGTTTCATAATTTTCAATAGTCTTTGCTGTAGTTGAAGCAAAGGTGCCGAAGCGGGTTTCGCTTGTAAAGCCTTGTTGATAAAA TCCATAGCATTTTGATATTTCTCGTGTAAAATTATGAATTTTACTTCCCTAAGAAATTGGGCTTCGTTTTCGTTATATAAATTT GTGGTGCTCGGAGTTTGGTTTTCTAAGATATTAATATTTTTTAGTCTTTTAACAATCGAATTAATAATTTCGTCTGCCGAATTT AAATTTTGCTCGTTTTCGTACGGAATATTGATTAAACGACTCGCTTCGGAGATTTCGTTAGCAAAACTATTATCGCTAATTTCT GTTAATATTACTAATTTTGAGGCTAGCGCATTCTTTCTATCCCGGTACTCTGTTTTATCATCATCGTCCCACTCATCGTTAGTC GTGTTTTCGTTTTCGGAAGCCGTACTAACAGGTTCTAAGGCTATACGTCTACTCATAATTTGAGCGACATGTTCGATACCTTTT GTTTCTTTTAGAGGTTCTTTTTCTATTTCAACCTTTTTCAATGTAGGTCTTTTCTTAATAGCCTCTAATAGGGCGCTTCTGGGG TCTACTGTAGTTTCAGGTTTAGGTGGGGTAGAACGTTCTGCGGCAGATTTTAATGCTGGCCTAGATCTTATTTGTTCCATTAGT TTACTAGGGTCTAAAGGCGATTCGGAAGGTTTTGGAGGAGACGGTGTCGATGTTTCTAAACCCGACATTGGCGGAGCAGGCGGT GCCTCGCTAGCTGTGGGCATAGGCGGTGGGGGCGGAGGACCAAAATCTGAAGCCATCGGCGGAGGCGGAGGAGGAACAAAATCT GAAACCATCGGCGGAGGCGGAGGCGGCGGTGGTGGTATGCTCGTTTCTAGCTCTTTCATAGGAGGCGGCGGAGGTATGTTTGTA ATAGGTTCAGGAGGCGGCGGAGGCGGCGGTGGCATGAAAGGTTCAACTATTTTATCGTTTACCGTAGATATAAAATCGTTGGAT GTAAGTAGAATGTCTTCCACACGTTTAACTAACTCACCATAGTTTTGATCGGGAATAACAGTTTTAATGTTTTGATCATCAGTT TCGTTCGAAACAATTGGTGCTACTATCGTTTCCCTGTTCAAACTTTTGTCGGCGCCTTTTGTGGCGATATCATCCAACGAAACT ATATCATTGAGAATGCTATCGATCTTTTCGGTGTCCTTTTGAATCTTTTGGTTGTGATCGTGTAAATATTTTTTATACACGACA AAAAATTGTTTATAGTTATCTTCTACGTTTGTTTCATTTTGAATTTCGTCAATTATCGAAAGTAGCAATGATTTATTTTCATCG TTGTCGTCTACTTTTCTGGCAATGTTTATTAAAATTTTGACTTTATTATCAACCGATTTAACTATGGGCAACGTCGTTTCTGTT TCTACATGACTTACCCTTTCCTGCTCATAAATTATGGCAGTGTTATTGTAAATATCATTGGCAAGTTGAATCAATTCTAACGAC TCTGCTAAAGTAAGTTTCAGCAGTTCGTTTTTGGGAGTAGCAAAAACTTTACGTTTCAGTTTATTTATTTGGGGACTTTTGATC ATATGCATTAATTTGATAGGTTCAATTAAAGATTCATGTATAAAATAATCTCTGGCGGATTGTATGTCAGTTCGGTCTAGTCTT TTCTCAAACATGGACATTGTGGTTGACGATTTAGACGAGTTTAAACAAAATTTAACTCTAGAAAAAAATATTAAACTTATAAAT GGAAAATTTGGCAAAGTGTCCGTGTGGCGCCACGAGCCCACTAAAAAACTATTTTTACTGAAGCAAATAACTCATGGTTATAAT GAAATCGAACCTATGATTCATTATTTGATGAAAAAAAACAAGTACTTTTTAAATCTTTACTACTCTGTCAATTCGCCAACTACT AATATACTTATTATGGACTACATCGCCGATGGTGACCTGTTTGATCTTCTGCGCCGCGAGTCCCGCTTGCCCGAACCCGAAGTC CGCAGCATTATTTTACAGCTAGTCGACGCTCTACAAGCCCTACATAAAAACTTCATTATACATAACGATGTCAAGCTGGAAAAT GTTTTGTACCATAGAAAGAGACAAATTTATTTGTGTGACTATGGACTCTGCCGCATAGTCGGAGTCAAGTCTTGCCAAGACGGC ACTTTAGATTATTTCTCACCCGAAAAAATCATGGGAAGAAACTATGACTTTGGATTTGACTGGTGGTCAGTCGGTGTTCTAACC TACGAGCTAATCACAGGAACCCATCCATACAAATTTGATCCGGACGAAGACCTCACTACAAATGTTCTGCAGCGAAGGCAGCAA AGAAAACTTGAATTTAAACCTAGCGTGTCTATAGCTGCTCAGTCTTTTATTGAAAAATTACTGTTTTATAATATTAACTATAGA TTAACTAGTGGTGATGAAATAAAATTAAACAAGTTTTTGCAATAAAAAAATTTATTTCATTTATAACTATAGTACCCTATACAA AATACTAGAGAATACAGGTTATTAATACTAATACTATGCTAAGTTTATACAATAAATGCTTAAATGTTAGTACACTTAAATTTT TTGTCGTGTTCCGTATGAATATGATTAACAATGATATCTGACATGCAATCTGTATTTAACAATTTGTGGGACACATTTGACAAA AATATGTTACGTTTTTTAAGTTCCTGAAACTTTTGTTTAACAATTTCATCGTTAGTTTTATATAAAACTTGCCGCTGGTTACAA ATTTGCTGCGGCTTAGGCATAGGATCAGCACTGACAATGATGACATCATCATCGTCGTCATCATTGTCAGCCACATTAATAACT TTAACCGATTCGTCAATTACTTCAACGTCCTCATCGGGTTCTTTTTTAATTATAGGCTCGTTATCTTGAACTATGGCAGAAATT ACAAAAGGTTCGTCATCAGCGGGCTCGGTTTTAATTACGCGCGAAGTTGACATTGTAGTTATTAAATCGGAAATGTCAGCTGTC TTATGTGACTTATGTGATTTAGATTTGCGCGATTTTGACTTTTTAGTTTTCTCTGGCAGCGGCTCGGGCGCCAATATGTGGTTA CGGTCTAAATTCTGGTCTAAAATCAGGTTCTCCACAGCCGCTGCGGTAGAATCATCAAACTGAGCTAAAACGTCTTCAAAGTTA ATAATAGGTATAGCGGGATTGTTAGAATCAAATATGTATGATTCCTCTGGTTCGCGAACCGAAGCCGGCTCGTTTTTCATAATA TATATTTTGTTATTTTTCTCAAAGTATTTGACCCCATTGTGTATTATTTCTTGCGCCTCACTGACAAAATCTGTTAGATTTTTA CCTCTAATCGCGTCAGACCTATCAATTGCCGGGGCCGGTTGGTCACCAAGAATTTGTTCCAATTCTTGGGCAGGTTGTTCACCG AGAATTAGTTCTAATTGTTTTTCTTGCTCCAGAATAGCCTGCCTTTCTCTTTCACACTTGTTTATTTTTTTTTGAAGCTCGATA ATGGCGGCTTCATTGTCGGTGTTAGATGTACGAATCACACTACGGCTACGATCAGTATTAGCGACTTTTACCTTTAATCCTTTT TTAGGTTTTCTGTTACGGCTGCGGCTGCGTCTTTCATGGACAACGGCGGGGCTGTAAGGTTCATTTTGTCGCTCAGATCGAGCG GGGCTGAGGCTTTGCTGAGGTTGGTCGGGACTAGGGCTACGGCGGCTGAAGGTAGGACTGGGGCTGCGGTGGTTGGCAGGGCTG GGGCTGCGGCGGGTTGCGGCTGAATGCTGGCTGAAGGCGGGGCTAGGCGTGCGCTCGTTCGAACCAAAACGATGTCCGACACAA GGACTCGGAGTTCTGGTTCTGTCATTGCGGGCAGGGGTCGGGTCCCTGCTTAAAGCGGGACTCGGAGTTCTGGTACGGTCGCCA TTGCGTGACCCGCTCTGGCTGCGAGAGCGAGATCTGCTTTTGCGCTCACTAGATTGGCTGCGGGAACGGCTTCTACACGTTTCG CTCGATTGGCTGCGGGAACGGTCGCTGTCGTCAGCGACGGAACGCTGGCCAGAAGTGGACCGGCGACTTTTACGAATAGAAACG GACCGGGATCGGTCTGATGTCTCGCTGCCGGAAGGACTTGAAGATCGGGTTCGGTTGCCATGGTTAATAATATCGCTTTGGTCG CTTTCGTGTGAACTGTTACTATAACTACGTTTACTGACACGACTATCGGTACGGTTTAACGCGGGCTTCTTTTTTCCTTTTTTT AGAATTACATTATCTTTAAGGCCTCGCGAAATGGCAATGGCTTCGGCCACTTCAAATGGGGTTTCTTCGCGTTTATAGTTACAT TTAATACACGCGCCTCTCTGATAACTTTCAATGAAACAATCGCTGCACAATTTATGTTCGCAGTTTTTGTAAAAGCTTCTAATA AAAGATTTTTTACACGCCTCGCATATTATAGTTTGCAATTCTTTATTACCGTTACATTGACTGATTATTTCAGAACTGATTTTA ATTTTAACTAAATTATTAATTTTATTGATAAGATCTTTCCGAAGATTTTCAATGGCAGTGAGGCCACATTTGTCCATAATCCTA ATATGTTCTCGAATTTCATAGGTCGCGCCTATGTTACGCAAGTTTTTAGGAACGTGTTGAATCTGTTCGTAAAAAAACTCGCTA GAAGCAATAAAGTCGTGTTTAGACCCATTGGACATCTCCAACAATACGTTATGGACCGTGCCGAAAGCGCTGTTATTATCTCCT AAAGTGGGATAGTAATGATTGTAAAAGGCTCCATAACACAGTCTGAGATGAATCAAAACATCAAACTGAGTCAGACACGTCAGT AAAGTTTGTAAGTCTTTTTTTACTTGGAGGTTAGGCGATTCTATAATGTAATTATAGATGTTTTCATAGTTTCGTGTCAGTAAA TTACGATTTTTAAAGGTAATACCCATAAATTTAAACGTATTAGTATTAGTGTAGTCTAAAAAGGCGACCTTTTTTTTCCCGGCT TGAAATTCAAGATAGAAATAAAGCCTGCCCTCAGGTTTATTATTAACCATTTGCAACTTTTTGTACGAGTTCTGAAAATAAAGG AAAAAACTTAGAGTTTGTCACTCTAAAAAAAAAAAACACAAAATTATTTACAAGTCCAAAAATGGGAAACATAAAAAAACACTG TTACTCACATCAAGTAGACGGCTCATCCTGTGCACTTCACTGGACTTTGCAGGGAGAAGAGGTGTTGCGTGTTCGAAGCTCGAA ACGAAACTGAATCCAAGTTTCGCTACCAAGGCTTATATACCCTGGCTGGCGACCTTGTGGGCGTAATCAGTCACGCGGCTGCGG GCGTAAACAAAGTCAGTCACGTACGCCCTGACCTCCAGACGAACGGAACAAACAACCTAATCAGCAGCGCTTATCGGCGCATGA CCGGAGATTGTTATCCGGTCACGTAGGCGCTCGTTTGTCACGTAGGCGCTTGTTTGTCACGTACGCCAGGAAGGTGATAAGCAG TTTTTTGCTCTACAAAAAAGGACCTAAAATCGTAGTATATTGGGAGCATATTGTACAGTGTAGACTATTATAGTAAAATAGTCT ACGATATGAAATATTCCACTGTATATTAGCTGTAAGGACTTAAGTAACTTTTTTGCACTGCAAAAAAATGACCTTTCGATTCTG GACTAGTCGTGCTTGATTAGATTAGGTTTCGTATAAAAGGCCTGACAAATTGAACACGAATCATACTTTCGTACGGAGCCCTAC ATACCAACAGATAACCGGCCGTAGCATCATGAACAAAGTGAGTATTCTTGTGTATTATTTTTGTGCATATCCTGTCAGACATAG TTTGTTCGTTTTATTTATTTTGTTTTTTGTTTCAGATCGACAAAAAATCTGTTACCAAAATCGAATTATTTAAACCTACTATTT ACAGCCTGAGAAAAAATAACAAAGATTTTGTCCATCACACCGAATTTACTAACCTCATGTTCAATAATTTAATTCGTCAGTATA AAATTTCTGAAAAAGAAACTGGCGACGCAAAAAAATTACGCCAAATAGATGCTTTTAATTTTTGTCGTTACATCCAAAATTACT ACGAATTTAACACAGATCAAAGTTCTTTTTATTTGTATAATATCAGAACTGCCGTTATTAAATATGATTTGATTTTAAGGATGG AAAAGTTTAAAAAATTTGTTAAAAGGCGCTACTTCAAAGAACATGGCGTACGTATGCATCAGGATAAAGTTATGTGTCCTGACA AACATTACGTGGACATTTACAAACCTAAACTTACAAAAATTCACCTCACAAGTAAAGAAGAAAAATATTCGGACGACTCTGATC TGGACAGCTCGGAGGATGAAGGCTTCGGAGGACTACGCCAGCGACCTCGGTCTCCTATTAGGTTTAGGATTGTAAATAACACGA GAGTAATGTCGCGTTACTATCCTCAGTATTAATTATAACAGTATTTTATAGTATTACAGTATTATATAGTATTCAATAAACATT ATTATGGTATTTTTTGTTTCAATTATCTCGCCATAGGTTCTAGAGGTTTGGTTAACAATTGTTTAAAAATAAAAATGCCAATGG CAAGCATAATTAATAAACCCCCTACCAACATGATTAAAGGCAAAAGTTTTTCTCCCAAACTTTTACTTTTATTCATGGATTTGT TAACCAGACCTTCTTCTCCGAGCAAATGATCTAGACCTAAATCTCCTATCAGATCTCCTAAATTGTAGGGTTCTATACATTGGA TAGTTTGGCCGACAGACAAATCAGAAATGTCAACATACTGAGGTGACTCTGGGTCGGCATTAGGATCGCTAGCTCTACAAACTG TCTGTTCTGTTTCGTAATTAAACCCCCTGCAAAGTTCCAGCAGCTCTTGCTCATTCGAAATTAGCGGGTCGAATTCGCATAAAA CTACTCTGTCCATTGCGTCCGCATTCAGCTGACAGGTTCTGTGTCTGAGCATACAAACAGTCATATCATCGCCTCCGTTAAAAC CCACATAAAAATAGCTACCGCCAGTGTTATTCAATGCATTGATTATGTCCTGAATTAAGCTAGCGGTGCTAAATGCCAAATATA CACCCGTACCGATGAGAGCTGTAACGCCTGCAAGTTTTAAATTTTCTAAGTATGTGCGCAAACGAGGCTGTTGAGTAAGCACAG TTTCCACACCGTTTGCGTTTCGTGTGTTTGTAGACGGATAGTTTTGTTTAACCGCATTTTTACGCAAATTAATGGAATGTAAAT TAGCATCGGGAACATTGTCTATACGGCGTAAAGATCCTAAAGAATTTAACTGGCCGTTAGTTGCGTCGGGAAACATGGTTCGTA AGTTTGTACTGTCATTATTGCGCATAAATCGATTCATGTCAGCGACACTAACAAAATCATTGTTTCTGACCAAATAACCTGGCA TGTACATGTCATTGTTTAGGTTTCGAAAACTTGAAGACGAAAAAACGTTTTGAAAACCAGCAGGGGAGGAGTTGACGACATTTA AATTGTCTACATTAAGAAATTGATTAGGGTTATTATAAACTTTATTAACTCTACGCAATGAGGTAAAGAAACTCATTTTTCCTT ATTTACTTTTTAGGCTTAGTTCTACGCGTTTCAGGCGTAGGTTCAGGCTCGGGCTCCGGTTCTGGCTCAGGTTCCGGCTCTGGC TCAGGTTCGGGCTCCGGCTCTGGGTCGAGATCAGGATTAAGAGTTTCATCAATTTTATCTACGGTAGTTTGGATAGTTTGTAGA GTCTCTGACTGAGCCTGCAGTGCCTCATTAATTTCGGACACATCTGGCAGATTGGCTCTGATGTCTTGCACCGATGCCTGTAGC GCCGCGACTTTAGTGTCCACGGCTTTAATATCGGATCGAATCAAAACCAAAATATTTTGGGACATGATTATTTAATATACAAAT GATTATGTATTATAACTTATTAACGGCCCGTCAAACCTCACCCTGTCAATTTCGTATTCACCCTCTGATAAAGTTATAACAATT TCGTGGTCGTTATAAAAAACATTAATATTTCTGGGCAAATCTCGATACGTATTTTTATTTTGATCAACAGTTAACGCATACCTT TTGAGCATGAAACTAGAATCGCCAACGTACGGCAATTGTTTTGTACCATACACGGACATACCTTGCAAAAATTTATGGAACGAA ACAGATTTATCAAAGTTCATTTGACCGGACACTAATTTCTCGGGACGTATGCCCGTTATAGGAAAAATGACCAGGCCGTTTTTA TAGTCATTGTGACGACAAGTAATTACTGAAATTAGTCGATTTTCTCTAAAAACGGGCGCGCCCAAGTAAATTTTGTTTGCCAGA CTAAAATCAGTGAGTGCAAACGCATACATTTGACCATAAATTAACCTTTGTTTGTGGATATGAAAATTTGCATACACACGATCC ACCGTAAAACTAGCCAGATCGCCGTTATTTAACAAAACATCTAACGCGGAATTGTTCGATACTTTAGGGAACACAATATTGCTC GCTACGCCGGGAAATTGGTGCAGCAGACCATATTCCTCGTCGTGTACACGGCTCATGGGCGCTATGATTTTAATAAACGATTCT TGCCCGTCAACTTTTGTTATTGTAACAGTCTTTTTTAGCTCGTTTTTTTCATAGTTAACATTATTAATTTCTAAATTTTGACCG TTTCTGATACAGAGCAATAGCAATAACAAAAATGTCATTGTCCTTTTTATAATCATATCTTATTAGTTCTTTAACCTTTGATAA AAATTACTATATAATTGTCTCGTTTCTCGAGATGAATCACAGAATCACACAGCATCTTAAGATATATCCATCATCATGCCGGTT ACAAAATGCAAGCAAATACCCGCCTACCAGTTTATTCAAAAACTCAATTCATTGCTACGCAACATTAGTTCTGTGGAAAAACGG ATCGATCATTGGAAGAGAATTAAACGGATTACAAAGGATAAACGAGAACTCATCGAAATAGATTGTATGCTGGCAAAAATGGAT GCTGAACTTAGATCACTAAGAAACGATGTATTGGTTTTAAACAGTAAATAAAATAAAATATTTTTATAAATTGTATTTTATTCA ATATCATCTTCACAAACTTCCACATCAATTATAGATCCATTTTCGTACCAATCTTCATCCACGTTTTCGCTAGTTTCCACCGCT GCAGGCGTTTTCTCCGGTATTTTGACTCGATGCCGATTATTATGAAATCCGTTTCTAACCAAATAGCATTTAAAAGGTTCACCA CTGGGCCAGTAAACACGCCGGTTCACATTCAACAAGCGGTTAGCCGTATAGCGGCAATGTAGTATTAATTTTTTGCGCGTACAG GAATCCCAGTCAATATCGAGCCTACCGCCGCAAACATGGTTAAGAAACTCTTTGGTGAACCTTTTGGCATAGTTGGTACCGTTA ATGTGAAATATGTACATTTTTAATCGGTTTGCTCGATATTGAAAAATATCATAGGTTTGATGGCCAACGAGTATGTTTTCTCTT GGTACTTCTTATTGTTAACACTTTCCAACGTAGTTTCGTTCTTACTCTGCTTGAATCCCTCAATTATAGCGCCCATATACAGAT CCACTTCTTGAGAGGGCTGTGCTTGTTCTCCGCCTTCTTGTTGGAACGCGAATAAATCGTTGTAACGTTCCACGGTAAATGGCT CACACACAACGCTTTTGACCAAGTCTCCTGTGCTATAAACGGTCTCGTTGCTGTGCTGCTTTATATCATAAAATTTTCGCACAA ACGAGATCTTACCCGGGTTATTTTCATCGGGCGCGTTTATTATGGAACAGTCTTGCAATTTTATTTGGTCCTCTTTGAAATATT GTGACATGATGTTGGAATAGATCATATTATGCCGATTGATATTGGACCAGCGCAGAATAAAGAACTCACCAAAAGTACTTTTGT AGCGCTTCATTTTCACCGTATCGAAAAAATAAAACGGTATAGCTCCTCCTTTGACATGATAACCCACGTTGTACACCACTCTAG GCGCTTTAGGGGTTTCTATGGTGATCTTGTCATCGATCTTTGGATACAAACGGCTTTCCCATCGAGAAAAGTTGTTGCACGTTT CCAAAAATCCTAGCGCCGTTTCCAATTGATTCTGATTAAACTCTGTCTGGCAATTAACCACCGTGATGTTCTTGCCCTTGGCCA AATTGTGTATCATTTTTTCGACCCATGTCATGGCACGCGTCTCTTCACGATTTTTAAAAATGCAAATCAACTTATCGTTAGCGT CATATTCCACTTCGGTTTTGTAAATGTCCAAACTATCGCAGCTTTTTTTGGACACCGACATACCGTCCGAGGAATCGCTTGATC TACGCTTGGTAGCCATTATTAAAATAATGTTGCACTTAATTTAAGGTTACTATTTATACTATGGAACCGTTTACCACCGATGAA CTACTCTTCGAAATTACCCTTTAAATTTTCTCAATACATTGATATATTAAATTTAACCAAAGGTGTTATATCCAAAAACATTTT GCCATGTTTTATTAACGAACTCAACAAAATCCCCCGAATCGATTTGGATCCCGACACACGTTTCATAAAAAACGCTTTCGATTA CAATTATTACATCAAGGAAAATGACATTTCCAAGATTTATGTAGTCGATGCCGAAACAAAAGTGTGTATTTCTCAAATTACAGT AGCAATGGTTGACGAAAATTGCATTAAACTGTTTGTAGACCTAGTATAAATTTTGGAACCACGGCACCTCGCCAATCTCGTCGG TCAAAGATCGCATAGTCAAAAAATATTTAAACGAATCTTCGAAAAACATGTACATTCCTATGAGTAAAAATATCACGAAAAACA CAATAACGTTTTCAGTGTGCGGCAAAAAATAAATAATCAGAGCGCTCGCAAACCACAAATATGCCAAGTTTTTATGGCCACTTT CGTGGTACAAAATATTATTGTGTCGTTCTGTGTAGAGCATAAATTCTAGCCGCGAATACATAGAACTCGAAGCTAAAACGCTAC CAACCAAAGTTACTTCGTCAAAATCGTCGATAACTTTACTGTCTTCAAAATTCAAAAGCTGACCATTGGAATTTACTTCCAACG CAGACACGTAATCTAAAATATAAAACAATGAATCGAACATGGCCTCGTCATCTTCCTCAATTAAATCATCAAAAAACTCCGGCA AAAACTCAATCATGTCCCGCGTTTCTCCCATCGACTCGAAATAAGCGCTCAAAAACGACCGCGACATATCGTCGGGAAATTCAC GAGGAAACATGTTGCTATAGCCGAACGGGTCCCACAGCATGAGCACCAGATCAGTTATGGTTAGTAGAATTAACAGAATGCCTA CCACCGATGCAGCTTTGATGGCAATTTTGGTCATGGCTTTAGCCACTGCAGAAATAGTTTTAATAGCGATACGGTTGAAAGAAT GAACGATTGCCGCTTTGTAGGTTTCGCCCAATAATTTTACCGTTACTTGTTTAGACGAAGTTAGCAAAACTCTTTTCAATAATG GTATTAAAGAACTATTAATTTTCTTTAACATAGCTTTAAGTTGATCGAAAACGACATCGAAACCTATGCTAGTGAGAATGCCAA ACAAAAACGCGTGATCCTCCAAAAACTGGGAAATTATCTCGTCCAATGTAGCGTTGTCAATTTCGTTAGTAAGCGGTACGAAAC CGGATTCGCCAAGTTTAATACGTTCCTCAATTATTCGTTTCGAAATAGATTCTTTAGAAAAACCATTTTGAGCGCGGTAAATCA ATTTAACGTTTTCGTTTATACCCAAATCTGACAACGTTTCAAAGTTGACCATGTCAATTTCTCTTTCCAAGTCCACAAAAGAAT CTCGCTGATTTAGCCAAGAGTCTAGTACGTGAGCAGAGTTCGCGGCCGGTTTCGTGGGCAATTCGGGCGATGGACGCGTGTAGT CAAAGTGTCTCAGTTCGCTAAAAATATTATTAGCCATAAGCTTGAAAGTGACATAGATAGTATCGCCTAACACAAAACCTATTA AGCTTTCCCACCATCGCAACGAGCATCCGCCGTTGATGAGCTCGCGTCCAAATCGGCGGCAATAAGCCTCGTTGAATTCGCCTT TGAACATTTCGGGAAACAACGGATCATCACTGGGCGTTACATTGAAGCCCGGCACATCGTCGACACCCTGAATCAAATGTTCGT CGGTACGCAAGTACGGCGAATTCATGTACATTTTTGACAAAGTGTCTACCAAAATACATTTATTACCGTTTTCAATGTACCTCA ATTCTGGCGATTGAACTTCGTTTTCGGCTCCTTCTCGTGTGGCCATTGCCCGGTCAAGATTGTAACATGCGGGCTGGGCATAAC CGACGGCCACATCAGACGTTTGAGTATAACCAAAGGGTGTCGCGTAATCCGCCGGGCCGGTTTCATGAAACGGATAGCAAGACA TACTCTCGCAACCGACTTTACTAAATTTTAGGCTAACGGCGATGGCGCGTTCGGCTAGTTTGGGCGGCACATAATAGTCGTCAT TGTTGGCCGGTCGAATTTCATAGTCAACAAATATGTGGGGAAATTTGGTTCTCCAACGTGGTATGAAATTCAGGCGGTGCATGT GTGTCGCATAGCGAGAAGCGTTGGTCAAATCTAGAATCGTTAAACTTGTCATAGTAATTTTTACTTATGATTTCGTGTATAAAC GAAACTAGAATTTGAGTAAAATCTTACTCATATTCAAGTTTCGTTGATATATATTTTTACTAGTCTTTTGTGAAACAACGAAAT TAGAATATGAGTAAGATCCTACTCATATCCAAGTTTCGTTTATTTCCATACAATGAAATTTAGATTCGAGTAAGATCCTACCCC AATTCAGATTTCGATGGTTAGGTGTAAAAAAAACAAGAATTATTTACTCATACCATATTTTAATATACAATATACATCGCATTT TTCACAAGTATTGTCTTTTAGATGATTACATATAACAAAACATTTACCCAAACATTCATCGGTACAATAAAGTTCTCGCATGTA CACGCTGCGACCTAATCGCGAAGTCGATTTTCTGCATTTCGTGCACACCATAGTTTGAACGGCATTATCAAAATACGGACTCAA CATGGTTTTACTGATCGTGTTAATGAACAACATATCGATCAAAGTTTTGGGCAAAAAGCACTTTGAAATAAACGCCTCTAAACG GGTATCCAATTCGAGTACGGGCATAATTTTTTTTCCCTCAGTAATTTCGCCGCTAAGTTTGTTCAAACACAAATTAACCAAACT GCGAGGAGTCTTGTGCCATTCGTTTACTCTTCGAACGATATTTTCATAGACATCTTCTAATCGTTCATACTGCTTCAAGTCTAC ATTTATGTCATAGTTGTAACAGCGCAACAAACGCTCTTCGTTTTCCACCAAAACTGCGGGGCAAGTTTTATAGAACATTCGGCC CTTTAATTCTTTGTAGCGTTTGTTCAACAAATTATATGGTCGTATGTCGAAATTATCATCGTAACATTTGTCTACATGGGTGTA AAACGAACCCAGACGGGCAAAGTTCGTTTCATATTTCGTCCACAGGATGGATACAGAATGTGTCGAAGAGCAATATTTTTGTAT TTTTTGAGAAAAACTCAACTTTTCATTGTAAGAATCGACACGGTCCAAATTTATAACTATTATAGACGTCATGTTCACACAATT TTAACATGATAACTGTCGAAACTTGGATATGGGTAAAATCTTACTCATATTCTAGTTTCGTTCAAGAGAATATATAAAGTTATT AATTAATTATGACTATCATTATTTTTAAAGCACTCATCATGGCACAAGTGAAAATCGGTCAATTCAAATTCGGCGAGGACCTGT TCAACCTGCGGTACGTGCTGGATCAAAATCAGCAAGTAAAATTTGTGGCCAAAGACATCGCGAATAAATTAAATTATTTAGATA CTAAAAAAGCTGTGAAAGACCACGTTGACGAAAAATATAAATGTAAGTTCGAGCAGGGGGGGCGATTTGTCGCCCCTGCCTCCG ACAGCGTAGCCAAGAGGGGTGACCCGTTGTATTTACAACCACATACTGTACTCATCAGTAAGGAAGGCGTCATCCAGCTTATTA TGAAGAGCAAACTGCCTTACGCCGTGGAACTGCAAGCGTGGCTGTTGGAAGAAGTGATTCCGCAGGTGCTATGCACGGGCAAAT ACGACCCGGCTTTAAAACAGCAACAAGAGGAAAACAAGCAGCTGGTAACCAAACTAATAGCGACATTCACCGAACACACTAACG AGCTACAGAAACAACTAGTGAAAAAACAAGAGTTTATTGAGCATGTCGTCGCTATGAAAGACAAACAAATCGAAGCAAAGGACA AGCAGGTGATGCGCGTGATGACCGATCTAAACCGCATGTACACCGGATTCCAGGAAACCATGCAGCGCAAAGATGAGTTGTTGC AAACTAAAGATGAGCAAGTTAGCGAACTTGTTAACAAAATAATGGACCTATCGGATCGTGCGGTGCAGTACCCAGCGGACGAGC GCAAGCACCCGGTCCTGTGCGTGGCGCGCGACGGTACCACCTTTACGGCCATCGCCGGGCAAAAATCCTATGTGCACAACCAAA AACAAAAACGCAACATTGATGAGGACAACATCGTGGTCGAAACGAGGCGGCCCAATCCCACCGTGGACTGGAACAACGCGACGG AGCAAGTTTCGATGCCGGCCAAAAAAAGCAGACGGTCCATTAGTTTCGACTCGCCGGAGGACGCCCAGCAGTTCGAAGATCAGA TCAAACAATTGATGAACAAATAAATTTTAAAATGAACCAAATTCTTTTATTTCATACAACGAAACTCGAATATGGGTAAGATTT TACTCTTAAATGTATAGCATCATATTCGAGTTTCGTTTTGAGCAAGTCTAAACTTGTCTAGATGATGTCATGTGGATGGGTGAC CTAATGGGTCGGTCTGCTCAAATAGAAATTTCGCATGTGAGTATGTTTGAAACGATCTTTTGGGATGGGTGAGTAAATCTCATA TGTAGTTTTGTATTTGTCAACATGATGTTATGTAGTGTGTAATCATACATCCGTTTGCGTAAACAACGGATGTATGAGATCATC GGTATGAGATCATCGAATGAATAAAAAAAATATTTCACAACAACAGTTTTTATTTCACAATCATTTCACAGCAATTTTCTTAAA CTCTGTTAAATCATAATACAACAAGCTACCTAAAATCCGTTTCTTCATTTTAACACACAGTTTATAGTAATCAATCTTGGAAAT GTCAATTTTGTTAATGAAATACCACGGATTTGTAAATCCACAGTACACACAGTAAAGAATCAAATTATTCTTGTACATCTTTCC GCGGCACTTTTCGCATTCCAACTTTATACAAGGCAAAGCAAAAAATGCGGTATAATCAAAATTAGTATTGTAAACTTTGCGATG CACCACATAATAGTATGTTAGATTCAAGTGAGTATGCCCGTTGACGAACTTCAGAATGTTACTTTCTTCGGGCACGACTCTGAT CAAACCGTCCTCTATTTCATGCTTGCGAGCCGAAAACTCGTCGAGATTTTTTTGCAAAAAAAATCTGTTGGCCGATTCTGACAC CAATGTTTTCTCCAGAGTGCAAATATCCACGCTTATAATTTGTTCGTTTGCCTTCTTGGCGTCCACTATAGATTTGAAAAATTC ATACACGTTTTCGTGGGTTTCTTTCACGGTATTTTTAACAATTTTGTGGCTCAGATCCACGGGAAACAAATAGCGGTTGACGAA GCGAAGTTCGCACAACTTTTCCACCACATCGAGATACAATCGAGGAAACAGTTCGTAAAAATCGTAATTGGAATCGAATTGATT GCTCAAATAACAATCAAAACAGTTCATTTTGAACTTTTCCATAGCAGTTTGGGGTGTAGTAATATCGATACTTTTGTCGCTTCT CACATATAATTTTCTAGATTGAGACCCGGAAAACGGCTCGCGACATAGATCGCAAAAAGTTGACACCACCACGTCCCGATTGTT GTGGCGCAAACAATCCATGAGATTTTTGTTGGTCACAAAATATCTGCCCTGTATGTACTCGTTGGCGAATTGAAGGACGGAGCA CATTAAATAATAGTTTTGGTTAGACAAAAATCGCCATCGCAAGTCCTTGCGAAGCGTGGCGCGCGGTGCGGGCACGGGAGTCGT CATTATTATGTGGAGGAAACTTCAACGAAATGTTGGCTTATATCATGTATTTTGAGTTCATAATTCGGTCTCATCTCAATTATT TAAATTCGTTTCCGGCGCACTTCCTTCTCCTACCACGCCGTTGGGGTCTATATAAGTTCTGTTGACAAAAATTCGATGACAGTT TTGTGGTATCCACAATGGATTACACCATCTCTAATAACACAATGGAAGCTGACAGCGAGTCCTCCACGCACTTTTGCAATATGG GCGAGGATTTTTTCAAAGAGGTAATACTAAAGTTTATATTTTCTAACCACTACAAACCCACTTTACCTTTGAATCCCAAACAAC AACACGAACTCAGATTGGCAGCATTCGATATCGTTAACAAAATGTTTCTTCAAATGTACAACGAACCGATTCCGCCCCTGTTAA TGTTTCGCGAAGTTGACGATGAAATTTTATTGTCGAAAGAGCGGTGTTCTCATCACTTGATCGAGACCATTGCCAAAGTTTGCG CCGCGATTAACCAACTCAAGAGCATGCCCAAATATAAACACCAAATTTTTATTTTCCTTCCTTACTTGAAACAGTTAAAAACTA TTTTGTCTTGTTTTGTCAACGATTATTGCTGCGGAAAGATCGTTAATAAAACCCTAAAAAATTTAACCACACTGATAGACACCG GACAAAGTTCTCTTGAAACTATCAAAACACTTTTCGAGCGTGTGCAAGTGATGAACGTGTTTCGCGACGACATTCATTTATATC AATGTAATATTTGCCACGAAACTTCGGCTGAGAGCCATTTCCTTAAACCTAATGAATGTTGCGGCTACAAAATTTGCCAGGCGT GTTACGCGAACCTTTGGAAATTTAGCAATCTGTATCCCGTGTGTCCCGTGTGTAAACAGAGTTTTAAAAAATCCAGCAGCGGCA AATAGACGATTGTTTTGTGGTAGTTTTTATTATTAAGTATGAATTCGTTACACAGTCTAGAAGAGAGACAATATAAATTTTTGT TTCTAGCCAGTTACTTTAATCTCAACGATTATGATCACTTGCAAACGGACAGCAAACCGTTCATCGGCGAATATTTAAAAAACA ACTTTGCCAATTTGAACGAGGAAAGTTTATTGTCATACATTGATTATTTACATTCCATCAACCTAAAGTTTTTAATCGCCGATC GTACCACGGACGTTTTCAAATATATCAAACCCCAGTTCAAGTTTAAATGTATCAAAAATAATATTGATATTTTGGAGTTTGACA ACAAAACCTACATCCAACCTAACACGGCCATTTACGCCACCAATTTTTTTGTAAAAGATCCGAAAGATTTTCGATTGCTCATGT ATCAGCAATTTTCTCAGGTGTTTAGCGACAGGCATTTTGTTAGTAACGGAGAAAACTATTGTTTAATGAACGGAAACGTCGGGT ACATTTTCGAAGACTCGTACTTGGATTGGTGCGGCGCGCGCATGTGTAGCGTGCCAAGAATAGAGGAAACGTTTCATCCCTTTC GTTTGTATTTGATCGGCGACGAAATGGCCCACCATTTTATCGTTAATAACATCGCTTTTGATAAAAGCAACATGTGGATTTTTA AAAATTTTCATAAAGGTTTGCCACTATTTAAAACCAACTATCGGCTCATAAACTCTAAAAAATTTCAAACTAAAAAACCTAATG AACTTTTCAATGAAATGAGACAAGAGTTGGATCGTACCGAATACATTAAGTTTATCCAACGAGATTATATTTACGATGCCAACT TCCCCGAAGATTTGCTCGAGGAACTCAACGAGTACATGAGCAAAACAGCCATTTACAAGTTTATTACCAAATTTATAGAACCGC ATGAACGTATGTCCAATTTTTACTCTGAAATTATTGTGGACAGATATGCGATAAATAAGTACCGCAAATTAAATATAAAAATTG AACCGTCCACGCTCTTTCCATCTTTGCGAATTAACGATCCTTCATATATTTTTGTACGACCCGACATAATTCAAATCAAAGGCA CTCTGAACGCGTTTTACGTACCCAAAGAAAAACTGTTTGCTATTTTGGCGAGCAACAGTTTGTTCGGTTCCACCGAACTTTTGC ATTTCGACATCAGATTAATTCCCTACAAACAGAGTTCGCCTCCAAAACGGTTGGAACTCGAAACTTTCATAGTAAACAAACAAC AAAAACTATATTTGACTAAATTTATTTTCGGTAACAGGATCCCTGCATATCTTTTAATAAGAGGTGATTACGAAAGTTCATTTA AAACTTTGGATCATTTAAAAAATCCTTGGGTAGAGAACACGCTTCTTAAGTTGTTAAACACACCTATTCGCGCATAAAATGGAA GATTTGAGAAGTCCCGCGGGCGGTGTAGGTGGCCGTTTTGGCTCGTTTTTCAATCCTAGCGTCCTTATGACGGTGTTAATTTTT CTTGTGATTATCATTCTTATGATCATGCTTTTCCAGTCTAGTAGCAGCGGTGGTAACAACAGTAGTTCTCCCGCGCAAGGTGCC ACAACAACATATACCAATCCTTTGAACGCAACAATGAGAGCCAATCCTTTTATTAACTCTCCCCAACGCCTATAATCTAAGTGA AATTCTTAAACTGTAACACGATGAAACGATTCAAATGTCAAACTCCTAAAGTTAGGACCGTCACTGAAATTATTCACAGTGACG AAAGGTTAAAAAAAGAATATGATATGGCAGAATTCGATGCCAAAAATCTCAACAGTCTGGAAGGGTTTAACGCTGTTCGCATTA AAATGATTATAGTCAAGTACATGGCCATGTTGAACACCCTAGATTTGAGTCAGCCTCTCTTAACGATTTTTCGCGATCGCAACG CCACTGTTGACATAACAAAAATTATTATCGGTTCTTTGGGGTATGTTCATAGGCGGGTGAATCCTTTAGTCACGAATTTCGAGG GCAGAATGGAAACGGTCATTATCGAAAATCCCCAACATAGCATCGCGGGTGAACCCATTTATTTTACGGAAACCGAAAAAGGCG ACATTCGTTGCCATATTGACCGTGTCAGTATCGTTCGTATGTTGGAACGCCATTACGATATGGACGTTAAGATAAACGATTCGC CTCTCAACCAAAATAAACTAAAGTTAATGCAAGCGCTAACATTGAGCGGGAGTAGCAAGCGTAGAAGAAGCCACGATACTTCCC GATACGATTTGCAATTGACAGAAGTCGAGTGCACCCGCTACCTAACTCTACTGTTAATAATCGAGCATGCCTATTGTCACTATG TTATCCTTAAAACTTTCGACACGTACAATTATGTCAAATCGCTGTTAGACCATTCGTTGTTTGCTCACAAGTGCCGCCCCGGTG TCAACATGAACTTGTCAAGTTTACTTTTAAGTAAATTTAAATTTACTGTAGAAGAATTTGATCCGAACAAAAGTAGCAATAAAA ATTTGGGCATACTAAACTATAAGTCGTAATGTGGCTTATGCTAGCCTTTTTTATCATAGTAAAACTGTTGGTATTTCACAAACT ACAAAAAATGCACCTCGACATGCACGTTGCTAAAATTTGCCCTAACGGTTTCCACGGACTCGCCCCCGATCCTTTCGATTGCTC CAGCTACTATTTGTGTCCGCAATCGATTCAAATGTTTTGCACCGAAAATACCCAATTTGATCTGGAAACGAATTCGTGTGTGCC ACAATCGTTTGAGAGCGGCTGTCTCGGTAGATTGTATAAAAATTTGTTAATTTAATCGCACACAATTCTTACCGGGTCGTTTTT GGTTTTAATATTTCGCCACATGTGTGTCACGATTTCAAAGTTTTTTTCATGTGAAATCGGCTTTGACAATATTGAAATAAAGTT AGCCGGCACATTTCCAGTAACCGCGATCAATTCTTTTTTGATGAATACATCTCGGCCGTTTTCGTCTACCAAGTTTACGCCTTT AATTTTTTTTGTCGAAAGTAACTCGGTTTTTCGTCGGACGGAGAATATGTGCCAAACTTGATCTTCCGTTTTCGATGTCATCAC AACTAACGAAAGCGGCGTAGTAAAATATTCATTAAAAATTAGTTTCGAATAAATGTACGGCAAACGAACACAGCTCACAACGAA GCCGTCTTTAAACTTTTTCATGTCAATTTCGTTTAAAATATCTAAAACGACATGCACTTTTCGTTTTGGTGTATTTTCGTAGCC GCTAACCAATTTGGTACTAATAACTTCGTCTTTATCATCCTTTTCTGTGTCGTCACAAAACAAAACAATATTAAATCCGTTTAT CGAAGTAGGACAGACGAATGTGATAATGCTGTTATCGTATGTGGGTCGGTATAAATGGACCTTCATTTTTTATTTGGTTTCAGT ATACGATCAACGTTGCCGAGTTCGATCAACTACTTACAATGAAGAACCAAGCTAGCAACATGCCCTGCTTGGACAGAAACGTTT CACCTTATGTAAGTTTTGAAAAAACACCACACAGGGAAGACATTCGCAACGAGTCTCCTGAGCCGCCAAGCGCCGATATAGATA CTTTAATGAAAACGGTCAACGAGATCGTGGAAACTATGGAGCAGGGAACTTCGGCGGCAACGACACCGATTAACGTCACACCGC CTACCATGCCGATTGGTAAAAAACAAATTTCTTTTAAAAGAAGCCATAGCAAAAGTGATGACATGAAAAGTAGCAAGAAAAAAC GTCCCACTTTGACAGATTTGGCTAAAACTGATATTCATGAAGAAACAGAAAAAGAAAAGCAAAAAAAAAGTTCAGTCGCCAAGA TTCGCGGACCGTACCGCAAACTAAAAATCGACAAGGCTGTGCCTATTACGCACCATATCAAGCAGGTGACTTTTGAACAGCAAA ACCAAATTATTAACAGTGCCACCGACTTGATTAGGGAAAATACAAGCCAGATCAACGAGCTATACGGAAACCAATATACAGACG ACCGCCGATTTACCGATTGTATCAGTAGTACGTATTACTACATGTTTATTGTGTGCGAAGACAATAACAATGGTAATGTTTACA AAATTCATTATGTGAATTGTGTGGCTAGGGTTACCGTAGAGTATGCTGCTCGTTACAGTTGCATTGATAATTATGTGATGGTAG TTTCCATTAACAATCACAGATTCATGATTTCGTATAATCTGTTGAAAAAATTAAACGTTAAAATCCCCAAATCGGAAGATTTTA ACGAATCTTCCAAAAACAAAAATAAATGTCAGTTTAACGAAGTTAAAGATATCGATTTCATGGCCACATTGATTAACATGTTTC ACTTAGATATTTGTTATGTTCAGTCGAACATGATGTTAATGTTGGCGGCGCTAGGTCCGAGCAAAGCGCCTTTCATAGCCGACC GGTTGTATTACATGATCAACCAGTCTGTAATATTTAATTTACCCATCAATTTGGCCATTAAAGAGAGTCAGTCTACGGAAAATG TGGACGATATTTCTGCCTATGTGCAGGAAATTATGAAGTATTCAGCAAAGGCCAAGTTTGAAACTCTTAAACATGGCGAAATCG GTATGGACAAGATTGTAAAACATGTCGACATGTGGTTTAACAACAAAAAAGATAAAACCTGGCCTTTCTTTTTTACTTACAAAT ACGGTAGCGTAGTGAGAATTTTTTACAACAAAAACGATGATAGTTTCAACAAATTGTTGAAGGTTAAAAACCGAAAGGAAAACA ATGGTGTTAATTTGATTGAGACATATTTAAATTCTAGCGTAAATTCTGACACTTCCGAAAATTTCATTTTGATTAACGTGAAAG CCGACGAGCGCATTACGATTATAAAAAAGGGAAAAAAATATGTCTGGATCAGCACCGTGTGCAAGGAAATTAACGTTTTAGACA TTATTTCAAAGTTTAGACGCTTCAGGCACCATATTTTCGATGTAAGCTGCGTTGCTCGCAAAGAGCTCAATAATACGCACAACG CCATGATCACTTTGGCCAGTTTCTATGTAAAGAATGTTATCAGTAGCAAACAGGCCGAGGAGATTGCCTCGCAAAAGTTTAACG TCAAATACAGGTCTAAAAATTATGAGTAAATATTGTGTAAATAGTTTAAGCCTTTTTATTATAGTTTTAAGCCTTTTTATATTA CCCTATGAGATTATTATGTGTTTATTTTAAATAAATTTTTTAAAAATAAATTTTTGTTTATCCTTCATCCTCATCACCCACATC CATACTTTGAATGTTTGCCTGGTCGACATCATCGGCAACATTGTGGCCGTAATAGGTTAGCAATTCTTTGAGACTGGAAAAGCC GGTCAAATCTCTAAGTAGAATTTGAGCATTCGCTTTCCAAAACTCCAAGCTCAGATAGGTGTAGTACAGCTCAATAAAACTAAT GATGCCCATTTCGCTGTTGAGAAATTCAATGTATTCTTCATAATTTTCCTTTTCGTTTTTAGTAAAAATATACTTTTTGTGAAA ATCACAGCGGGTCTGATCATTGCGATGGTAACATAGTCGACAGTGTTCAAACTTCTCGGTCTGTAACGCGTTTAGATAGTCTCT CGTCTCGTCGGACACTTCTAAAACGACTTTTATATCGAAATTATCATCCTTTTTCCTTTGCAACAACAAACCGTGCGCCCCCAA ATACTGAACCACATCGCCCAACTTAGAGTCGGGATTGACGGGACAGTCTTTGGTTATGGTAGCGGTCAGCTTTTTAAGATCGCG CCTAAAATCATTCATTCTTATAAGAGTGAGAATTCATAATGCAGATTTTTGTAAAAACTCTAACGGGTAAAACTATTACCTTAG AAGTGGAATCAGCGGACACGATAGAAATTATCAAACAAAAAATTGCCGAAAAAGAAGGCATTCCGCCCGACCAGCAGAGATTAA TTTTTGCCGGCAAGCAATTGGAGGATAGTAGGACAATAAGTGATTACAACATACAAAAAGAATCTACGCTACACTTGGTATTAA GACTCAGGGGTGGCTGAAAAAAATGGGTGGATAATATAAAGAAACAAAAAAAATTTTTTTTTACATTTTTATTTATTTCAAAAT ACATCTATTCGGACATTTGACTATCTTCAAAAGTGTCATTACTCATTACAAATTCTGTCTTTTTAACACGCTTGCTAGTGGTGT TGGATTTGACAGAGTCTTTTGTATTTTTCCTTTTTCGTACAGGGGCAGGAACGACGTCGGTTGGAGTTGATGAATGGCTCGTAT TCCTCTTCTTGTACAGTACTTTGACAAAAGTTTTTAGAGGGTTTTGGATTTTTGAACTGTTCAATTTTTCATTGTTCACAGTGT ACGCATAAAAGGGATCATCTATAGGAGCGTGTAAATTTTCAGAGTCCAGTGTGTGCGTAAGCAGACGATAAAATTGTTCATAAA TAACATTTCGTTTCGCGTTGATAATTTCGTGTTTCTTGGTTTCTTCGTTTTCATTCGTAACTTCAATAGATTTGCCCAGTTTTT CCACAAAGTCGAACAGATTGATAAAATCTGCTGATTCTGTCTTCATCAAGTTCCACATGTCACAGCTGCTGGGATACCACTCTT TTTTGATGCTGTGATACCAACTATTAAAAAGAATATATTTATTGTTGCTGATGATCTTTTTGCTGCGTTTAATGTTCTTCTTTT CGTCCCCGTAAACCGGCACCACCTGCAGTACATAAGGCATTTTTTTCTTTTCGCACAAGCTAATGTTCTGTCCTAGAAAATCAT TTTTAGTCTTGTTATACACGCTTTGTTCACTCTTGTTGATGATTTCTGCGAGTGTTTGAGGCGCCATTGTATCTTGAGGAGGAT CGCTTGTATTCAGTGAATAAATCAGTGTTTAAATTAAACACGTTTTCTATACGTTTGTGGTGCGACACTAAACGCTTGCGATTC TGGCTACAGTCCGCAATTACAAAGGCGCTTTTTAGATTATCCCTTATATACTTCATTTGCGTTTCAAATGCCTCTTCGAAAATG TGAGCGCAAACTCCAGTGTAATCGCCTGAATGTTTTCTCTTGTTTATCACTTCTCTAACAAGCGCGTAAATTTCGCTGCGGGTC ACGCAAGATTCATCAAATTTTTCAATTCCGTTTTTGCTAAAGCCGAAATCTTTTTGCGTTTTTGTTGACATGTCGGTGTTTGCC GCTGGTAAATGTCTAGTTTTAACGACAGCAAAAAAAATTCATTTAAAGAACCGTAATCAAATTTTTTTTTAATGGTTTTCACAA AGTCAAAAAATTCCAAATAATTGCTCGAATCGTAAGTGAAAAGTTGCTTTTCGTTCATGTACTGGAAATAATCATCGAGCGGCA GAATATATAGGTTGCGTTGAATTTCGTTGTTGTATCGGCGAGTTTCAATGTTAATTTTGTAATCGTTGGGACGAAACAGTCTCA GCTTGACACAAAAAGTGTTGGGCTCTTGCGGAATGCTTTGCAACGGACCGTTCAAAATGCCAATGTAAATGGCATACTTGTACG TCACACCACAGTCATTCCACTGTAGCACAAAAGGACTTTTGTAAACATGGGCGCTTTCGAAAAAAGTGCCCGTTTCTTCGATAA ACTCTCTGATGGCAGTTTCGTAATCAAATATGTCCTGTCCGTCGCGCTTACCGCGCGGTATGGATATTTTTTCTAGGAATGTTA TAGCGTTGTTGGTGTTGAAGGCGGCATTGTACGCGCGTCGAGCCCTCAAAAGCACGGCGCGGTTATGGTCCATTATCATGAAAA GACCGGCACACTTCATGCCTCAAGTAAATAATAACACTACTGTTATAAATATGACGTGTATTTTTATTATATATCAACATATTT AACTTATTATGAACAATTACATTTGGAACAGCTATGACATTGGCACAAACGTTTCATTTACAATTGAACAATTCGGTGACTGTA ATGAGTGCCCGTTTTTATTCGTTTTCCCTTAATGAAATCGATTTTAATTTCATTGTTATTTTGCACAACTCTAGATTGAGCGGC CGATCTTTTTATAGAGTTCAATCTACGCGTGGACAATTCCAGCGGATTATACAACAAAGATTTTTCCAGCGTAAAGGAATTTAA GTGCCCACCATTGTGCCACTCCAACGAAATTATCATATTCAACAAGAAAATTATTTCAGAGTCTCTTTTTTCAAACACAAACTT ATTTTGCAAACAATAATAGTACAGTTTTAAGGAATTATACAAATAAAACATGTAATTGTTAGTTTTATAATAATGATCCACATC GGTCACGAACAGCACATTGATGATCTTGTCCTGGATGAGTTGGCTAAACTTTAATAAATACTGCATGGAATTTTTGTCGTCGTC AATACAAATCGCACACACGTTTTTCAGATAGACGTTTTCGATCACCACAAATTGATTGTTAACAAAAAGTTCTTTGAGGTTTTC GTTGTAATCATTGGCAAGTTCGAGCACTATGTATTTTTTGGCACATCGGTGCCGCTTGATCACGTCCGAAATCGAAGCGATGGA CGAGAGAAACTTTTCAAAATACTTATCGTTTTTCCAGCCTCTAGCGCCGATCGTTTTGCGCGGATCGTCGTTATTCTGATGTTT GAAATCCAAACCACTTTGTATAAGTTTGGTGGTGATGCGAATGCTCAATTGCTGACCCAAGGTATAATTATTTTCATATCCACG TTCCCACATAACGTTACAAGCGAACGCTATCAAATCGGCTACGTCGTTTTGCTTTAACATTTTATGCAATCTATCAAAGTCACC CTTGTACCAACGATCTCGCGCCATCAACTTTAGCATATTTTTATCGTGCTCGTTTAACGATTTTCGACTCACGTCAATGTATTG GTCGATTTGGTCGGGCTTGCTGCTCCTCAAGCACGCCATGTCGAACACAACTACTTTTCTGTGTAGAGTGATAAAATTTTCATC GTCAACATCAATACTTTCCCACAAAATATGCTTTGACGTTTTCGGTGGCATGCCTTGCAAATGTAACAAATAATTGCCGATGGG ATCGGCAAGGTACTTGCAGCATTGCGGCAAACGTTGCGTGGAAGTTTTGTAGTAGATAGCAAACATTGTGACGCCCGCCATACA AATGATATCACATATCTTGTCTGCATATATATAGCCCGTCATTTCGATAAAAGTTTTAGTTTATGTTCAACACCAGCAGCATAA TGAATAGCAAGTATCATTTCAATCCTGCGAAACTGGAGATTATGGCTAAAATGTCGTTGGACAACAACGTGGCAGTGTCTAAAT TTTTGCCAAAACATCTTGCCATGCAATTTCAATTTTGCCTGAGGTGTAACATTACTACTGTAGAAAAAAGCTTTAATAGGATCT CCTATTGCTACGACTGCGGTTCCAAGTGCCAACACTGTGACAAGCCTGGCAGAGTTCGCCGGCTGGAAACGTTACACGGATGGA CCACGGACATGGAGTCGTTGGAACGACATTTCAACATTCGATTGAAAGATGTCATGACGGTCCGCCGGCAGACTCACATGCAAT ATTACGATAATTACATATTTAATAATGTTGCATACAAAATTTTATGCTCAGATTGCAAGTACAATTTTTGCGCACTGTGCAAGG CAGAGATGCCCGAAAATGAAATGGTCAAGATCGGAGTAAGTTCCGGTACCCTGGAAATGACCCATGCGTTTTGCTGTAAAGAAT GCGTGTTACATTGCAAGTGTGTAGAGTGTCGGCGTACCATTAGCTTAGAGAACGTTTTAGAGTTTGAAAATAGCACGGCCGAAA TAATTTTTGGTGTGTATGGTTATTCTTACGTGTTGATTTGCTTTAACCACACTCATACAGTGACCGCTTGCAACGAGTGTACAT CTTGGCAATTTAACAATGTATGTGAAACATGTGAAATTGAAGGAAACAATAGGGAGTACATACACAATCATCAAACGTTTAATA ATCAAAACGTTACAGTTTGTGATGAGAACGAAGCAGTAATAAAAATGCTATGTCAAATCGATAATAGGCAAGTGCTTTTTAATT GTATTCAATCTGTGTCTGAACAATTATTCTATCCCATTTCTTTCGACACAGCCGTAGGGTACATAGAAAGAGGCATGCTTAACT TGGGTCGTAAGGAAGTGATAGAGCTGATTATTTACGCGATTGTTTCAAGAAAACGCGAGACTATAGTTAGCTTTTACGACCAAA CAGGCATACCGTGGTATACGTATAACAAGGAAATTTGTCCCGATTGTGAAGATAGGGAAAACATGTGTGTCTCTCGTAATAAAC CAAGGAATTTGTACCATACAGCTATGTATGATACTCAGTGCTGCAACACCACTAAATGTAAAGTGTATTCCGAAGATGACGATA TTTCTGATGTGTTTTTAAATGAATATAATTATTGTGAAAAATGTTTAAAACCTTTGTTTGAAATTATGGATGTACAATTCGATT CAGATTTTGTTTGCACTAACCAAGAATCTCTTGAATATTGCTAAGTTTTTAATAAACCTGTTTAATAAACCTGTTATATATTCG AAATCTGCCTGTTATTTATTATTCCCTAACTCACCATGCCAAAGTTAGGATCTACGGTAACGATAATTGATCGTTGCGCTTTTG AAGAGCGATTAAATCATGTAAAGTTTTTTGTGCAACTAATGAATGTTGTAATATGTGAAATGATCGCTTCGCACGAAATCACCA AAGCAGAAGGCGCGTCGTTGTGTTTAGCCGACGATACGGCCGCCTGGATTTGCGGACGCATTTCCGATTGCAACTTTGTCACTT TCCGTGTGAAAAGTTTATCATTTAACAAAATACAAAGTAAAATATTAAAGAAAAAATACAACTTTGAAGAAACTTACGAACAGC AACTATTGGGAAACGAGTGGCAATACCTAATTTACATAAACCGCACGTTCAAACAGGTAGCTATCAAATTGATTGTGGTCAGAG AGGACGTGCCCATGATTTATTCGAACCCGTACATAAAACTTTCGTATTTCATCAAATTGCAAGATTTGAACGTGAGCACTCTGG ACTGCGATTGTGGCAACGACAACGACGACCTACAGTGGTGTAACGAGATGGACCATTATCACCGTTCGCTTGCTGTACAAGCAG ACTTGTGTGAGGATAATCACAACGAAAATATTATTAGTTTAGTGTGTTTTTGTAAAAATAAAGTATATTATTAAGTTAACAAGA TGGTTATTATCTATTGGATTGTGTTAATAGCCGTGATCGTTTTTATTTTTTTGTATGTAACGTGGTCAGAAGAAGCGGCACCAT CCCCTAGCCCGCCTCCTAGTCCTCCAATAATAATAATAAACAATGAACTAAAAGACTTTGAGTATTATTTCGTTGAAACTTTAC CCGTATATTTTAGTCGCAAAGCTGAAAAAATTGCAAATCCCACTAGACAATGGAGTTCTAGTAGCGGTTTTGTCGGTTTAGACC CATGGACAAGTACTGTCGATTTTGGTACTTTTTGTCACACCATGATAGGTTATGCCGTTAACTTTGTGGACAAAAATAGTAACC AATATTACGATGAACAAATCGGTTATAATTTGTTGATGTGCCTTCGTCTTCTCTCTCATCATCTACCCGACACGCCGCCCGTTC AAAACGCGCCTTGGGGACCCGTGGCGGATTGGTATCACTTCTCAATTACCATGCCCGAAGTTTACATGACGGTAACTTGCGTTT TAAAAGATACAATTTATTATGAAACCGCCGCAGAGTTAACAAAAACTACGTTATCGAAGTACTTGCCCACCGCCACAACGTCTT TGGGATGGGTGAGAACGGCGGGCAACGCGATGCGCATGGGCGTGCCGTATGTTTATTCTCAATTGCTTAAAGGTTTCAACATTA GCCAAATACGAATGCAGGATTCTGTACAAGACGTGCTCAAAATTATTAGCTTTCCGTTTGTAACCGAAGGCAACGGATTGCACA TAGACTCAATTTACATAGATCATATTGATGTGAGGGCTTACGGATATTTGATTAATTCCTTCTTTACATTCGGTTACTACATGT GGTTCTTTGGTTCAGATGTCATTAATCACTACGGGCTAACCAAATCGATATTGAACGTTTCCTCCCCAGAAGGAATAGTAAACC CGGCAGTCATGTCGAGACAGGGCACTATGTTTTCCAATGTCATTGGAAACTTTGTCGATTATAAAATCGCCGTTCATTCTGCCG ATGTGAGTAAAGTGCTAACGAAATTAACAAACAAATATTACGGGTGCTGTGTGGGATACACTACCAAACTGGCATATTACGAAG CTGACCCGACCAACTTTAATCACGCACCTTTGTGGGCTATGAACCGCCGATTGTGGCGGCGAGATTATCCCATAATAAATTACA CACCCGAAACGGTCGGTTTTGAATCTGGCGTGCTTTTGCAAGACTTGAGCGGCCGATGGCCCGTGCCGTCCACGACCACCTCGA CACAATCGTTTAGACCTGTCATGGCCAAAACCGCCGTTGTGAAAAACGAAACTCTCGGCGCAATGTTAGGGTACGCAAAAATAA AAGAATTAAACGATTTAGAGTTTTATTCGTGTACGGTTTATTATGAAACGGGCATGGTACAACTTTATTACAACATGAAAATTC CAGTAGATACTTTGTCCATTAATCCTCGAATGGTTATTTTGACCAAACCTGTGATCGACCAATCGACCAACTGGAGTACATCAA ACAGCTTCAACACTGCCACATTCAATGGCGTAACTTGCCACCATGTCAATATAATCAATTTAGCAGGTTTAGCAAACTACGTGT ATAGACAAGTTAATGCCGTTGAAAATATTGAACAAATTATAGCAAGATCGGTTTTAGAAGAAGGCATGGGGATGTCATGTTACA AACTAACCGTGACCGAAACTAATGACAGCGTCACCGTTACTAACAATTCAAAATACAATAATTTCACTGTAAACATACCGAATG AGGGAATTTTTATATTTTATTTTCCATATTTAGCACTGTACGACGACAATCAGTTAATAATTTCAAACGCTGACGAGGACAATG AAATACCAAAAATGATAGTAGATAGTTTCATATACCAATTCGATATACAAGCCGATATGGAACCTTTCAATTGTGTCCTAATCA ATGACTTTTACCGAATATTTACCGACGAATACAGTTTTATTTTTAATAAGCTCTCCTAAACATGAATATCAACAGGTACACTAG TTGTTTTTTGTGCAACGAAATTGTTTATAGTTTTCGTCAATACAGCAATAAATCCTCAGACTTCTTTTTTAACAAACACAGATC TGTTTGTAAAAGTTCTGTGTATTTTTGTTTAAAGTGCTACAGAGATCTTTACGTGAAAAAGGTTGTAAAACTAAAAAATTTTAC AATCCCTAACCGTTTATTTAGTAAATAAAACACACAGAGAAAATTTTGTTTTTTTTTTATTGAATAATTGTATTGTTACAATGA AGCAAACTCAGCATGACGTTGTATTCGCCACTGTTATCGGGCAAATTAGAACTGCCCTTGACGCACTGCAAACTCTCCGTCCAA CGGTTGCCTGCAAACGACTGGTTTATGGTCCATTGATCTAGCCGAGTTCCTTCCACTTTTTCGTGGCCGGTATGGTTGATTTTT ATAAACTCTTTAAATATGTTGTCTGGCGTGTTATTGAAAAGCATGTACGGAATGTTGAAAATAGGATATCGCTTGGCGTTTGGA TTGTTAAAATCGCCTCCTCTCACCACATATTTTACTTCGACGTCCTCGAAATTAGATTGGCGAGAAAGATACGAAATGGGCGAC AAACATATTTGCGCGCAAGTCCCGTCTTCTGCGATCCACTCGGTCAAATCTTCGGCGCCGTTTATGACTCCTTTCTGGCCATGA ATACCGCATATTTTGATGCCTTCCAGATCGTCGGTTGAAGTTATCGTAACCAACTTTATGTACACTGTATCGTTAAAAATAGTA ATGATGGTGTCGATTTTATTGATCGCTTGGTTTTTTATTTGCCTCAGATACAGGTAAATCTTGAAAACGAAAAAGTTTTTGTTT TTGCACGCTTCAATTTTATATTTTTTACCGTCGTAAATCCAACCGATCTTTACGTTGGAAACAACGGTTCCCGCGATATGCAAC AAATTTCCACCTTCCACCGCCACACAATTGTTTTCTGGCGGAGGTTTAATCAACTTTACTACGGGAGTTTCGTTTTTAGTGTAA ATCATTTTTCCTTTTAGTTTGTTAATTTTATTATTGTATAGTCGAATGGGCAATTTGATGTCAGCGATGTAAGGATCCTCAGCC GTCATAAGTTTACTGTCACGCACAATCGTCCATAATTTGAACATTTTGTTGTTAAGTTTGATCTCCGGCTTGACAGCGACGCAA TTGCCAAACGGTAGCGTGTCCAAAAAAGTTTCATCGGTTTCACTGCTGGACAAAATCGGCATGGCATTTTTCAAGTTAGTTAAA GATACAATCAATTTGGGCGTCGGAATGGTGCTGTAGATTTTTAAAAAATTATTGTAATAATATTGAACCAACTTTGACATGAGA CAATCAACGCTGTCGTTTTCCATAATGATCCCCACGTCGGTAGTGCTGTTTAAGATAGAATGGCTGTTGTGGTATTCGTATGGA GTTAACAGCGTGGCGATAGTTGCCTGGTCGTTTACCTTCACTGTTCGTTTAATACAAATCATACCTTCGTGATGATTGATAAAT AAAATTCCGTTGGACATTTTCATCTCCACGGGCGTCATGCCCCGTTTAAATTCGTAAAAAATTTTGTACAAATCTGCTCGCTGA CAATAAAAAACGGTCGGACGATCGTTGAAAGTTAGCCACAAAGTTTTCGAATCCGCGTTAGAATTAAAAACATGGGTATCATTT TCGTCGATCATTTTAGTTATTAATTTTTGTTCAATTAATCTATTGAACTTTTCACGGACCATTTCATAATCCACGGTCGGTAGA CGAACGTTGCGGCATAAGAAAAATTTTTTACCCGCCACCGTCATTTCGCCGTGGAAAAAACTGTCCACGAACTTGACAAAGTCA TCTTTCTGCATCAACATGTCTTGGCGCATTGTGTCATTGGTGATCCTGACCACTTCGTTGCCGATGCGATATTTCAAGTGTGGC GGTGTTATTTCAATGTTATTGTTGCTACTATTGTCCTGATAATTTATGAAATTCTTTCTTTGCTTGCTAAAAGTTTTTGAAACG CTGTAAATCAGTTTTCCGTTGACGATAGTGTCCACGATTTTTTTGCTATCTTTGGGATACAAAATGGTTTGCATTTTCTTACGC TTTGTACTTTCACGGTTAAGTCCGTTGGATATCAAAGTTTTGTAATTATTTAGCACGGGACTGTAGATCAGCTCCAGCAGATAA ACGTGTTTGTATATAATTTTGTTGGCCAAACTGTCGATGGAATAATTGATGCCGGCTTTCATGATTTTCTTGATTTGTTCCACC AGCGTCTTGCTCTGGCACGGTTCGTATTCGAAAATATCGTTGAGAGGTTTCCATTTTCCGCTGTTTTTTAAATAGATGCCGAGA ATCGCGTTCAAATCCTCGGACACGACATAGTCACTTGCGTACACGTCTCTAGCGAATAAAACGTCCTCGTTGTTATCGTACACC AATTGTATGGCTCTATTGATTTTTTTCTCTTCGTCCACGTTACCGTAAAGAAACATGCGTTTGCAACTTTTGGAGTAGAGTTTG TCATAAAAATTGTGAATCAGAATATTGTTATTCATCATTATGTTGGGGAAACTGAGATTACGACCATCGATCATAAAAGTGCCA TCGAAATTGCAACTTTTGTTTGTGTCGTTTTTTCTAAATATATGATCGAGCCAAGTGCCGAAAATCACCACGACACATTTGTGA AGCACACACCGGTTTAAATTGTCGACGGCGCAGCAAAAGTATGATTTTCTTTCCAGCAAAAATTTGATCGTGCAATGATTTACG TTCTTTTCGTTGCAATTCAGGTAAAACGACAAACCGTAATTGTTTTTTAAATTATCATATAAGTTGTTAAAATCGTTAATAACA TCAGTCATAATGGAAACTAACAAAGCAACTGAATTTACCGAAGCGAATGATAACAATGACCCATCGGAACGTATGATATATACT AAAAGAATTCATGAGGGAAGAAAACGAAAATCATTGAATCCCATCACCACCAACCCCCGCAAAATTATTAGAGTTAGTAAAAGA AGATTTGAATATGAGAGCAATGAATTTCACCCTGATAATTTGAGATATGTGGATTTTTACACATTTTTAGATGTCGATTTTAAA AATTATAATCTAAATGATGTTTTAGCAAAAATTAAAAGTAAATATGAAACATTGAAAAATATACACTTTAATTCAGAATATTTC GAAGATACTTTAATTTTCATTAAATTTGTAAATCAAGTATTTAAAAATGAAGACGCGTTATCAGAATATAATACAACAACTATA CCAGTTTTAAATTTTTTAGAACTTGTAAATAAAATAAATGAATTTAAAAATTTCCTCGATGTGGTCAACGAAAAAATTAATGGG TCGAACATTCAAATGGAAAATAGACTAAATTTAAAAATAGTACCACGAAACACTAAAACTAACAGAGCTTTGATCACATGGGAT GTTCACCCGAATAACGTTAACAACGAAAACATCAATATTGAAAGTATTATTGCACATTTCAGTATTTATGGTGAAATAATAGGA GGGGTAATGTGTGAAAATAAACAAGGTTGTGCTGTTTTAGAATTTGCTTTATTGGATGATATGTTGAAAGCAATAAATAGGGAA CAAATGTACCGTGTTTCAGACTACACGGAAAATGAAATAGTAAAAATTCGCTCAGACACAATAACCAACTTAAAAGAACAGTTA CAAAATATACGATCCCAGATTGTTTGAATCGATTTCATAAGTATGCCTTTAATAATAGTCGTTATAACAAAAAATAAAAAATGG TTTAAAAGTACAAAACGGCGAGCCGTTAAACGATATACACAAAAGTCTCTATCAAAACTTGTAAAACGAAAATATATTGAATTC CGAGAAACTTGGATATGAGTAAAAATAAACTCGAATATAATTTTCGAATGGATCTCATTCAATGAAACTTGGATATGAGTAAAA ATAAACTCATATCCAAGTTTCGATTTAAACCTGTCGAGACTTGTCGGCATAATTATGGTGCAATAATTAAATGATGTCACGACG GCGTCCAACAGGTTGTGACCGGTTAGATCGAAACTGGAATATGAGTAAAATCATACTCACATTGAAAAATATACACTTTAATTC AGAATATTTCGAAGATACTTTAATTTTCATTAAATTTGTAAATCAAGTATTTAAAAATGAAGACGCGTTATCAGAATATAATAC AACAACTATACCAGTTTTAAATTTTTTAGAACTTGTAAATAAAATAAATGAATTTAAAAATTTCCTCGATGTGGTCAACGAAAA AATTAATGGGTCGAACATTCAAATGGAAAATAGACTAAATTTAAAAATAGTACCACGAAACACTAAAACTAACAGAGCTTTGAT CACATGGGATGTTCACCCGAATAACGTTAACAACGAAAACATCAATATTGAAAGTATCATTGCACATTTCAGTATTTATGGTGA AATAATAGGAGGGGTAATGTGTGAAAATAAACAAGGTTGTGCTGTTTTAGAATTTGCTTTATTGGATGATATGTTGAAAGCAAT AAATAGGGAACAAATGTACCGTGTTTCAGACTACACGGAAAATGAAATAGTAAAAATTCGCTCAGACACAATAACCAACTTAAA AGAACAGTTACAAAATATACGATCCCAGATTGTTTGAATCGATTTCATAAGTATGCCTTTAATAATAGTCGTTATAACAAAAAA TAAAAAATGGTTTAAAAGTACAAAACGGCGAGCCGTTAAACGATATACACAAAAGTCTCTATCAAAACTTGTAAAACGAAAATA TATTGAATTCTGAGAAACTTGGATATGAGTAAAAATAAACTCGAATATAATTTTCGAATGGATCTCATTCAATGAAACTTGGAT ATGAGTAAAAATAAACTCATATCCAAGTTTCGATTTAAACCTGTCGAGACTTGTCGGCATAATTATGGTGCAATAATTAAATGA TGTCACGATGGCGTCCAACAGGTTGTGACCGGTTAGATCGAAACTGGAATATGAGTAAAATCATACTCATATTCCAGTTTCGTT TTCTTTATAAAAGAGTAGTAAAAAATTTATAAACAAACTTTGAATTTGAGTAAAATCCTACTCATATTCCAGTTTCGTTGTTTT ATAAAATAGTAGTAAAAAATTTATAAACGAACTTTGATTTGGAGTAGGATCTTACTCATATTCCAGTTTCGTTTTCTTTATAAA CGAACTTTGAATTGGAGTAAGATTTTACTCATATTCCAGTTTCGTATATACAAATAAAATTGAAACAACAGATTGTTTTCAAAT GTAGTTTATTTGAAATAAAGGGAACAAACATCTTCGACAAAAAAGATCATAATTAAATTTCTTGGTTACTAATTCGCTATCACT AACACATGATTCACATTGCAAACATTGTTCGATATCAACTTTGTAAATTTTGTCGTGGGTTTCGTGTAAGGTCCATGCCATTTT TACTCGCGCGTTCCACACTGTGTAATCGTTTTCAGACACCTCATGCATGTTCATTTCCCAGTAACACACGCTCAGCAAACAGTA CATTGAAAATTCCTTGTCCGTTTTTAGTATGCACACGGGAAACAGGCAATTTTTACACAGCTCCGTTCCACTGTTGTCGGTGAA ACAATAATCGCAAACCGAAACGGCGCATGAAGATTGTCTCATAAACGGTTCTTTAAAGCTTGCCAACCGTTCATTACATTGGTC GAAAAATTGAGTTCTCACAGTGGGATCTGTAAGTTTTTTGTATAATTTTGAGTATTTAATAAAAGGCTCAATTAAATTCATGAT TAACGTTTAACCCTGATGAGTTGTGAATAAGTAATAACATGCTATTGATAATTAATTTACAGGATAAATCTGATTTCCTGTTTA GATCGTTTATCAAACTGTGGAAAGATACGTTTGTCGAGTGCCAAATTTGTTACGAAAAAATCGAAAATGACGGCGAAGTCGCCA TCACTGATAACGGCTCGATCAATTTAGAAAAAATGTTTCATTCAAAATGCATAACACGCTGGAGACTTGAAAACACTAGGGATC CTTTTAATCGCAACGTTAAGTTTTGGTTTAACTTTCCGCCTAAAAACCAAGCAGAGTGTAGCGCGCTGGTAAATCAGATTAAAA AATTCATTGGTGATAATGAAACCGACAAAAAATACGGCGCGGAATTTAAAAGAGTCAATGAAGAATCGTGTATAGATGTGGACA TTGACTTTACTAATTTATTACATTATTGAAGTTCAACGTGGTCTTTTGCACAATTACAACCACTTTAATATGATCGATCATGTT TTCTTTCTTAACTTTTAACGTTTTAATATTGTTAACATCGTTGTCATTAGTGTATTTGTAATAAACATTATTATGTATTCGAGA CAACACATGGTTAATTTTTTTCGTTAATATATTTTGATTGATGTGAACTTTTGATTGAAAACGTATGGGTACATTCATTTCCTC GTTCGGTTTAGTCACTTGCGCTTTCAAAAACCTTCTCAACATATTGATGGCTAAATTATTTACAACGCCACAAATTAACAACGA AATGTTGGTTTTGTTATGAGTGTAATTGACGTTAATTAAAATTGGCACGATATTTTCTATGTTATCCAGTAAACTATAGTAATA TTTAAAAATTAGCTCACTCATTTTTGAATAATTTCGTGCGTTTATATCGTATTTGCCAAAATTAGACATGATATCTTCGTACAA AATTTTATTTGATAACTTCGATGTAAGTTTAAGTATCTTCTCTAATTTTACGAACAGTTCGAAGTTCAGGTATGTTATTAAAAC GTTAAAGCCGTTTTGAATAGATTCTATATTTTCATGTACGATAGGCATCATTAACGGTTTGATTTGTATTATTTTTTGTCTATA TTCTATTATTTCGGCTGCGGTTTCGTTTGGATCGGGGTTATTTTCGGAATCATTATTATTATCTTGATATATAATATCATAATC AGGTATATCTTTGTTCGCCATACTTAAATTATACTTAATAAACTATTATTTGATAATCAGTATAATCATTTATAGTTTCTTTTT CTTCAAAAGTGCGAATAACTTTTTCTTCCAAAACATCATAATAATGAATTGATCCGTCGGCATTATAGGACATGGTTTTAAAAC GATTCAATTTATTAAATTCATTATAAGTAACTAGTTTTACTTTCGCATCATCAAATATGTCTTTTCTGTTATCGGAATCGGACG CCATAATAAAAAATATTCTAAAAAACAACCTCGAATTAATCGATGATACTTATATTATTTTAAATGTCATCGAAAACGACGAAA GTGGCAACGCCCAGATTCAACCAATGTGTATCGGAGAAATTAATTCCTTTCAAACCGATCAAATTACCTCAGACTCAATGTCCC TATCATCCTCTACGAGCGAATTGCCGACTGATCAAACCATGTGACCGATACGACCGAGAAGAAGATGCCGGCAAACACGTTACG GTTTTACAAGCTGCCACCGGCATCAATTATAACCTGCAGCCGTATTACATGTGCCTTTTAGACGACGCTGAACTGCGTGGCTAC AGTATGAACGCAAACGAATTTTTTGGCCATGTCCAGTTGAACAAACTAGATAATGACGAAGAATTTTTTGGTATAGACGCTGCC GGAGAAAAAAATATGGGAACTATAAAAATGGTAATCAAAAGTATTATGGACAGTTTCGCAACATGTGAAAATTATTACATTTTG ATGATTGACGAACTTCAACTCGATCTATTGTTTTCCATGTTCAGATCGATAATTTTACCTCAAAGAATGGTATCTATTCACAAA AACAATTTTGTGACCGACGATGTTTATTTTAAACTTTTCTCTGTACCCGTAACCGACGAATCGGATCAGTCGCAACAAATTTAC CGCACCTTTTTGATGTATAACACCGTGTTAACTATGATACTCAAACAGCCTAATCCTTTCAATGACGCTAGAAAAAACATTTCG GTGATTTTCAGAAGTCTGGGGCGATGTCCGAACAATAAAGAAAGAGTTAAATGTTGCGATTTAGCCTATGGCGGTAACGCGCCG AATCATGTAATGTGTCCTCCCCGCGAAATGGTCAAAAGAGTTTTCCATTACGCTAAATGGTCGCGCACGCCCAATAACTACAAA AGATACTACGAAAAAATTACCAACAAAATTGATGATTCAAGAAACGATCAAAGTTCATTATCAAAATATGCGCTATTGACGTTA GATTGGTACAATTTTATAGAAGATTTTCGTACATACTTTGGAGTCTGATGGCAAAATGCCCAAAGTTGACCTATTTAAACGTTG CGCATGTCCTATTTTTATTTATTAAACGAATTGAACTTTTATCAGAAGGAGGATCGGACGCGAAAAAAATGGACATCAATTTTA AGCTGAAAGAAATAATAAACACTACCGTGGATAACAAATATGGAGAAAAAAGCACCAAAATTTCCTTGGCCGATTTTTATAAGA AACATCAAGAAGACATTGCGTGCGTCGGAAAAAGCACCACATACAACTGTACCGGCAAACGTGACTACGAAAAACACCTAAGCG ACAAAAAATACAAATTCTAATGGACCGGCGAGTGGATGAAACTGACCAAGTGATTCGGTGTGCGCACTGCTTGTTTGTTGCTCC AATATCATTAAGTTATGAAGAATATCAATATTTACACAGGGTCTATAATAATTTGTTATGCCAAGATTGTTTTGCAAGTAACCC TTTCATGTCAACAACAGAATTGGATCCAACCACTAAGTTGGATGAAGTTTCTTGATGGATTGTTTTGTTTACCCAAATAGTTTG CCAGTTTTCCAATAAACAATTTAATAGAACTACACCAGCCTTTCATTATGTCTACCTTAACGCCGCTCCATATAAACGACGAAC ATTGCTTCGATAGTTTAGTTCGATTCGCAATGGCTACCAATATGAGCGCGCGCTTCTTGGAGTTTGAAGAAGTGTGTATTGATC TTAGAAATGTACACTTTAGTTTTGACCAGGACCATCAAAGTAACAATAAAACATTCATAATATTTATGAACGTGAAGCAAGCTT TTTATTCAAATTTCAAAATAAAAACGGATTTGTCACTTGAAACTTTGACATATTACATATATCAGCACTGTTTATGTACTGTGG AAGACACCGTTTTACCTATATTCCGGCGTTTCGACCAATTCATCTTTAATGAAAACGATAAATGTAAATCCATTATCATTCAGC TGCATCGGCGCGCCCGTGTCATTGTGGCTGAATGTATACGCGAGAACGAATATTACCATTCGGATGTGAGTGGTTACATTGATT TTGAAAACCGGCACACTAGATTACCGCTTTCGCTGAGCGAAGAGGAAAGATCGAAAATAAACCGAGAGGCACAATTAAAACTAC TGGAAACGACCTAAAATCTTTGAGAAGAGGTCTCGATGTAATCTTCGTCATCGGCGTCGTCATCGGTTTCGTCGTCATCGTCGT CGTGGTAGTGACGTTGTGTGGTATTGGCGGTAGTGTTATTGTTAGCGTTAATGTCATCATCATATTCATATTCGTCCTCGTCTT CATCGTAATCTAAGTCATTGTAAGAAAGGTGACTAGCTGTGTGAGGCGCATTAGCAGGCGCACTGGTAGATTCATCCTCGCTGT CGTAAATGTCGTGCCGTACAATGTGTTCAGCGGCAACCTTAGGAATCCACATGTTATTTAATTTTACATAATTACGTTCAATAG CCTTTCTAGCCATGTGCAGTGCCACGTCTTCGTTGGCGCTATCTAATTTATGATATTTATTAAAAGTGTCTTTAAAAAGTTTTT TTGCTTTAGCGGGAAGCTCCTCTTGGTAGTATGCGTCGGTTAGATGAAACATTTTATTATACCCTTACAATTACTCTGTATCGT AGTCGTCGTTTTCAGTGTCGGTGGTGTCAAAATCGTTGTCATTTGTATAAGCTAACCATCTGTAATTTTTCTTGTAATATTTTC TTTTAACCGCCGACCACGCTATACTATTGGCCGACACTTTTGATTTGTAATTTTTGTATGCACGATTAAAAAATTTCATGTATA TTCTACGACCATTGTAAGGAAGCCGTTTTACAGCGGAAGGTAACTCTGATATGCTGTCATACATTGTATTCTTAATAAATATAT TAAAAAAAAATTGTTTCATTAATTTTATTTTTCCTAAACTACAAAAATCAGATCCATTTTATGAGATTCAACAAATAATCACAA CCATTTAACGGGCATAAAATTATTGCCTGCAAGTCATATTAAATTAGATTCGGCACTGTCCAAACTATCAAACGACACACGTTT GGCCTTTACTAGCAATTCATGAATGTCGTTTTCGTTTTTAACAATATGCACAGTACTTCTGTCTGTTTTGCGAGCCATCACGCC GTTTTTACACAAACTTACATATTTGTAGTGAGGCAAAAGAGCGTCGCGAGTTTTCTTTAGGAGATTTTTGTGTTCCAAAGATGC GGCTACAAAAATTTTAACAGGCCCGTCATAATTTATGTTTAAATCGTAATTTTTGATTCTGATTTCACGCGACCGGTTTTGCCA CTCTCGAGCTGTGGCAGCATCCGTCAAATGAACTACGATATGATTTTTTTCGTAATCGTTTTCAATTACTTGTTTCAAATCTAG TTTTAAAAGAGAGCATATTTTTTTAATGTAATTTAGCCGGATTTTTTTGTTAGTCAGGCGTTTGTCGTGAATACCGTAAATTTC CACGCTGTCGTTTAGATTGATTATTTCTAATTTCTTAAGTTTTTCATTTAATTCGTTAACATTGCGGTCAATTTCGCGTTTAAT TAAAGTTTGTAAAATCGGCACGTTTATCAAGCTGTCGGCTTCCATGATGTTGGCAAGAATGTTTAAATCCGAAATACCCTCTTA TTAATAATTCAAACTCTGTTGTTAATTTCAGTCGCTATTATGGAGCACGACGCGCAAACACCCAAAATCAATTTTGTTGAGAAA AGTCCCGCTGTTTTTTCGATACTCACCAATCCCGATCAAATTAAGAATGTGTTTTTCATTAAAATTAACAAATTTAGATCGTTT TTAAAAAATTTTTTGGCGGATCTAAAAAAGGTTAAAATAAACTTTTTCAACAGCCTGATCGAACAGTTGATATCCGTTTACACG GAAAACAATGTGAGAAACGAGCACACCGAAACTCTCGTTAAAATAATCAACGCTACAACTATTGTCATTACCGACTTGCCGTCC AATGTGTTTTTGAAAAAACTTAAAACTAACAAGTTTACAGACACAATCGATTATCTTATCCTTCCTAATTTCATATTGTGGGAT CACAACTTTATAATTTTTTTGAACAAAGCTTTCAATTCGAAACACGAAAACGGTCTCGTGGACATTTCCGGAGCCATACAAAAG ATTAAATTAACACACGGTGTTATCAAAGACCAATTGCAAAGCAAAAATGGTTACGCTGGCCAATTTTTATATTCTACTTTCCTA AACACGGCATCGTTCTACGCCAATGTCCAATGTTTAAACGGCGTCAACGAAATTATCCCTCCGAAAGCGAGCATTAAACGCTAT TACGGCCGAGACGTTAAGAACGTTCGCGCATGGACCACTCGCCATCCCAACATTTCGCAATTGAGCACACAAATTTCAGATGTT CATCAACCAAAGGAATATACCGATTGGAACGTTAAAGTGGGCCTAGGAATATTCACCGGTGCAAACACAGATTGTGACGGTGAC AAAAAAGTAATTACTTTTCTACCTCAACCGAATTCGTTAATCGACTTGGAATGTTTGTTGTACGGAGACCCGAGATACAATTTT ATTTGTTTTGACAAGAATCGTCTGTCTTTTGTGTCTCAACAAATATATTATCTCTATAAAAACAGGAAAAATATAGAAGTGATT TTAAACACTATGCCTATGTTAAAAACGGTATGGCAAACATACGGCGATAGAAAGTTTTCCACCAAACTTGATATGCTGCTGCGG GATTGTGCATTATTATTGAGCTCAAATTGTAGTTATTTACTGTTTAAAGAATTAACAAACCTAATTGACGAAGAAGAAATGGTT TGCGGTGAAGAGGAAATATTCGAATTTAAAGGAATATTTAACGATGTGATCGACAGCGGAGCCAAAGGAAGTTACGACCTGATA AAAAGTACTAAAATTTACAAGGAAACCAGCTTCAAAGACATTGAAACCGTATCACAGCGAGCAATTAATAGTTTAAACAATTAC ATTTCGTCGCATAATCGTGTCAAGGTGGGCGGAGGCGATATTTACCACAATACCACAGTCTTACAAAACATTTATTTAAAAAAC AATAAAATTTGTTACAAAAGTGACTTTAGACAAATTGGCGATATTTGTACCTTGCCTTCGGAATTTTTATTTCCCGAACATTTG CTTGACACCTTTCTATGTTAACGATGTAAACAGAACCCGAATGCTGCCGAACAAGCACCGCTACAACATTGATCGTTTCGATTA CAGTTTCGTCCGGTCTCAACACACGCCATTGCATAGGCGACACATGCCATCAAAATTATTAATGTAGTTTTTAAACGCATTTTG ATTAAAACTTTATATAAACTTATGTTTAAAACTCATAGTGTGTACGGTCGAAAACGACATCGGCACAATTGTAGAACCCTTCGC CGGCCGGATCGTTTCTTTGCCAACGCACATACAATAAAAATGGGTTTTTTCTGAAAGGAACGTTTACGGGTATAGTGTAGACAA AATCCGAATTACAAAGTTTGTCATGTGGATACGAAACTAAATTTGATCCGTCGCCGCCGATTAGTTCGAGATCGTCCCACAACA AGTGATGTTTACGATTCCAGTTTTCTTTAGTAATATAAACTTCAAAGTAACTCGGCTCATGAATTGCGGTGGGACAGAATCTAA TCAAAGTTGGCGAAACGTCTTTTGATATAGTCGTAAGTTGCCAATTCGTAAAAGGTTCGTCCATACCGCTTTTGTCGCCAAAAA CTGCGCGGCTATCATTGGCTCCCGCGCCGCATAGTGTGTGGGGAACGACATTGGTCTTGATATGTTCAATGTCTTTGTAATTAG CACCGGCCATCGCTGCATATTCATGATACTGTTGAAACATGTATTGAGCGATTTGAGCGGACGAACCTGACGATTCGCCTTTGT CTAAATATTTATTATAAACTTTTTTGTAAGCGTTCCTGCATCCTTCGTCTATTATACTATCGCCATTTTCGGGCCAATAAAAAT TATTTTCTGAAAAACATATATATTGTCGAGCCACCGGATAGGACAAGTACCCATGCGACTGTACAAATCGAAACGAACTTAAAA TTACTATAGCAAAATTAATTAAAATCATATTGTTTATTAATTATGCCAGACTTAATTGAAAACAACGAGGATGATTTTTATATT ATATTGTATGAGTTTATTGAATTAATAATAAATAATATGGACGAGCCCGACACCGACAGCGGTTACGAGAGTACATAAAGAACG ACAAGCCTCAGAGCCCATCATTTCGGTATCGATATGAGAGACGGTTACATACACGACACGATTCACGCCCCTGTTATACCAGAG GGTAAAGCCGTATTATATGTCGCTACTACAAAGACATATGCACAAAATGACCAATACAAAATTGGTTACACCACTCGGATTCAC GGACGTTTATCTTCGTTCAACTGCGGCCGTGCCGAAGAAGACAAAATGTATTACTGTTTATACACTAGACCAATGTATAATTGT GCAAAGTTAAAAAGGCTGTTGAAAAAAAAATTGTCTTCACACCAATGTGGCGGAGATATGTTTAGGTTAAGTTTAGAAGAATTA GAGAATCTTATTGTTAAATGTTGTATTAAATTAAAAAAGGTATTACATTAATGTTTGGTTTTATTTTTATAGTTCATCCTTTAC TACTCTCAATCCCTCATTCATAGCGTTAAGTATGTCGCCATCATCGGCGTCAATTTCCCAAGCAAACAAGCCTCCCAGACCGTG GTCTAAAACATATTTAGCTTTAGCCAAAACCGATTTGCCATCATCGAATGTAATCAACTCTCCGGTTTGCGGCTTGAACGCGTA CGAGGCTTTGGCCACTTTATCGTAATTATATTCGTACGACGGCAAATCGGCTTTAATGTGACGATAATCTTTTACACCGTCCTC CCATGTGCCCGCAATGGGACCATCGGCGATTCCGGTAAAAGGATTTTGGTCGTTGTAATCTTTAACACCTCTCCATCCGCGACC GTACATCGCTACGCCCACAACGATCTTTTCGGGTAAAACTTTTTGTTTTAGCAAAGCGCGCACGGCAAAATCGGTGGTGTAGCG TTCGGTAGGGTTCCAAGTTGGAGCATAAAGATTAGTTTGATATCCAAGATCGTTTAAAGACCAAGCGCCTTTAAAATCGTAATT CATTAAAAAAATGTGATTCAGATATTTTTGAGCTTCTGTGTAATCGACCACGGCGATTTTGTCGTCGCCCGCACTGATGGCACT GGTTAATTCAAAAGTTTTGTTCATTTCATTTCCCAACTGATCTAGCATGTGGCGCAATTCTTTAAGCAACAAAGTATAGGTGAC TTTGTCATTTTCAACATCGCCTACATTTGGGTTGGCCCCTTTGCCGCCAGGAAACTCCCAATCAATATCGACTCCATCGAAAAA CTTCCAAGTCGACAAAAATTCCTTGACAGATTCTACGAACACGGCACGTTTTTTACCATCGTCAAAATGATAAAACGGATCCGA AAGTGTCCATCCGCCGATGGATGGCAAAACTTTTAGATGAGGATACGCTTTTTTAGCCGCCATTATTTGTCCAAAATTACCTTT GAAAGGTTCGTTCCATGCGGTAACTCCACGTTGCGGTTTTTGCACGGCCGCCCAAATGTCGTGGATAGTTACTTTGAAATCTTC CCGTCCGACGCAGGAACGTTGTAACGCTTCGAAACTGCCCGCGATAGTTTTAAGAGAATCGTTTATACCGTCACCGCCACAAAT AGGGATGAATCCGTACAAAAGATGACTAACATTTGGTATAGGAACTTTATCTAGAGGAAATTTTCTATCATAAACGCCCCATTC AACAAAATATGCCGCGACAACTTTGTCGCTCATGGGTAAATTATCAAAGTTTTTGTTATTTTCCTGAAATTCATAAGTTAAAGG GTCCAAATGATCACCGTTAGTATCGGCCACAGTTACGGGCACCGTTTGGCTCGTTGAACAACCGTCAGCGTTGCATAAACGAAC TTTCATTTCAAATTTTCCCCCCTTATCGGTTTGTATGGACGCTCGTTTGGGCTTGGCGTCTCCTCTCCACATTACAGTGTCATT GAAAACGATATAAGCAACATCGCCCGCTTCACCGTTCCACACGTTCCAACTGACCGGAATATCAATAGTTTTGTGAACACGAAC TAATTTTTCGTAGGCGGTGGCGGCGGGGTCGGTTTCTACTAGAGAATATTTACGTTCTGCCCAATCGATTTGCGCTACTCCCGG TATAGCAGCGAAACTTTCTAAAACACAAAATGAAAATATCAAGTAAAATAATGACGCCATTTTTATATTGATCTTACATAAGCT ATTTTAATTTAATGTATTTAAAGATGAAACTTTTATTGTTATTTTTATTAATCGCGGGCACTACTAGTGCAACTACTTTTGATT TATTAAAAGCGCCCGACTATTTCGAAAATTTTATTAGCAAATTCAATAAACACTACCCTGATACAGAAACCCGTAATTATCGTT TTAAAATTTTCAAACAAAATTTGGAGGAAATAAACAACAAAAATAAATTAAACAACTCTGCCGTTTACAGCATTAATAAATTTT CAGATTTGACCAAAAATGAAATTGTATCAAAATACACCGGTCTAACTTCGGCGGTAACCGCTCAAAATTTACAAGTCGGTTCAA ATTTTTGCAAAATAGTTTATTTAGATTCTCCACCGGGCGATAATTTACCCATAAACTTTGATTGGCGCATAAGTAACAAAGTTA CCTCTGTCAAAGACCAAGGGGCTTGTGGCAGCTGTTGGGCATTTTCAGCTTTGGGAAGTTTAGAATCGTTGTACGCGATTAAGC ATAACAAACTCATAAACTTTTCAGAACAACAATTGATCGATTGTGACAGAGTCAACATGGGCTGCGACGGAGGTTTGATGCATG TTGCTTTCGAGCAAATAATGAATGTGGGCGGCGTGATGGAGGAAAACGATTATCCCTACAGAGGAGTAAAATCCAGATGCGCCG CTGATCCCAGTAAATTTGTTGTAAGTCTAAGTTCATGTTCGCGATACATATTTCAAAACGAAGACACTTTGAAAAATGTATTAA TTACTCAGGGTCCTATTGCGATGGCCATTGATGCCACCAGTATTTCTACATACTCGAAAGGAATTATTAAATTCTGTGACAACT TTGGGGTGAATCATGCTGTATTGTTAGTGGGTTACGGAACCGAAAATAATGTAAATTACTGGACATTTAAAAATACATGGGGAA CAGATTGGGGAGAGGATGGATATTTCCGTGTCAAAAGAAACATCAATTCTTGCGGTCTAGTAAACGAGTTAGCGTCCACTGCTT CTATCAAATAAAACAAGTGTTTACTGCAAATATACTTTAATTTTTTCCTTTATTTTTTCACGACATATACAACAATTTTTGCAT CTTTCGGCGCATTGTTCACAAGTAGCAAAGTGGCCGCAGGGGCTAAAGCATATTTCTATCGACTTGTCGAAACATATCTTGCAA GTTTTGTTATCATCGTTTGGCGAAACTGTCGTTGACATCAATTTGTGTTCTTCTTTGAAATTTTGCAAGTCGGGATAAATTTTG TTTGACCAAATAGCTTTATCCTCCATGCAAATTTCGTCGTCAATTTCTTGCAGATCGGGCGCAGACGGCTGGGAACGTTTTACA AAGGAGCAATTTTTTGATGTGCTGTGAATAAACTCTACACTATCGTTTCGATTCAGCTTTACAATCACCAAACCGCAATCGACA CATCTAACTTCGTTGTTACGGCCATAAAAAAAGAATCCATTTTGAGCTAAAAGTTTCGCTTCCATTTTCACTCGTTTACGCGCC GTCTTGAATTTAATAAACGATTCTTTCCTTAAAGTTTCGTTTCGCTTCATTAATCTGATCGATTCGGAACACAGCGAATAGGTA TGATATTTCAAAAGTTTCGAATTCAATTTCGTAATTATGTATGAACAAAAAGCGCATTTAAAAGATTGGTCATCAAAATAAAAT CCGTTGCGTGCCATAAATTTTTTGTCTTGATTCATCAAGTTGGTGATGTCTTTGAAAGTTGCCAGACGATTTTCGTAATCGGTG TAAAAATTTTTAGGAGGCGGCAAACTTTTTAGGAACATTCGTTCCATTTTGTAATATGTTTAATAATTTTTTAAGAGCGCGTTT TTGTTTCAAAGCAAATTTGACAGTGTTTAAAGTAAAATTTTTGTGTTCTTTTCTTTCTGTTAATCGATTTTTGCCAATCAAATA TCGTTCAGAATTAGCGGCTCTCGAATGCAACGGTTTAAACACTGTACAAAATTCAAAGTTGGCTGCGAAATCTTTCAACAAAAT CTTTGTTTCCGAATGAAACGTATCGAATATTTTCAGGACACAATCGCCGCCCGGTTTTAGCGAGTTGAGAATGATCTTACATTC TTGGGCCAGTAGCGGTAACGTCAAAATTTCTTGGTCGTTTTCGTTACCTCTGACATCCGTGGCTCCGTCCGCTACAACCAACTC ACATTTTTTACCACACATTAGGTTTAACTCTAGTATAACAGATTCGTCAAAAATGTCACCGCTATTTTTGTAACCGTATATTTT TTTAAAGTTTTCATGATTATAATTATAATCAAGTTTTCCTCGCAAAGTTACACCGTAACCTTTGCAATCAAAATTTGTAGAATG AATGTAATTGGCAAACTGACCTGGTCCTCCGCATAAGTCCAAAAATACATTTACACGTTTGCATACATTAAACTTTTTGTCGAT ATCTTTGAGTTTGTTAAAGCACCTTTTTTTAACGACCCGTTTTTCCATAGCGTCGCGTGCGCGATGAATCGATTTATCATCGAT GTTATCAAGACTATTTTTGAGGTCATTCAATATTAATCTAAGTTTCGATTCCATAATGGATATAATTAATTGATAACAAAATGA TGATAATGCTGCATATAAAAGCGTACACAATTTGTATTAAAGTTATACCACTCGGTACAGCCGTAAACATAGGTCGATCCAGAG CCCTCCTCAAGGGTTCATTGGTGACTAACAACTGTTTATTTTTAATTTCGTATATCAACGGACGTTTATAATCAAAATTTTCAA AGTTTGCTTTGTTAATTCCAGTCCGAAAAGCTGAATATTTTGGGCTCGCTAGGAGTAAATCTATCATTAGATTTTTGTACGCCC GTTCACGAAACTCTGGCGAAACTTCGATTCTGTCAGCATTCAGGACACGCCACTTGACATCATCCAACATGTCTGATCACAAGA GAATATCTGCCGGGCTCGAAGATGTTCTGAACGACGTCGATATGGAGTACCAAGGGACAGAGCACCGTAATAAAAAAAGATCGT CTAGCAGTGGTAGATCATCGAAAAGATCTATCAAAGAAGACAACTACGAGCACGAATCGAAACGGTCCCGTAAGCGAAGGAGTG AAGAAGAAACTAAAGATATGGAACCGGAACAAACGACCTGTCCAAATAAACTTACCTATTGGGAAAAGAAAAGATTGTCGAATA AAACATCTTTAGCTTTGGCAACGCCCAGGATGTCCAGCGAATCGGTAACAGACCAGCCGTCTACTTCAAGCGGAGTACCACAAA CAAAACTACGCACTGTAAGTGTGAATGGTGAGCTGATTAGCAAGTTGCCAATCTCAATTAATAACAAATCATACTACATATTAA AGTTTTTGTGCGACCAAGAAACGAAAGAGTTCTATGGCAGTTCTGTTCACTTCACTGAAATAGTTAAAAATAACATGTACAAAT TAGAGGTGTCTCAAACACCCAGATTTTCGTACATTGAAAATTACCAGATTTTGAACAGTGTGAAACCCACAATGAAAGTGAAGA AAGCTCTAGATAACAGCGATTTTGACGATCAAGATGTTGTGTCGGTGATCGCTCGCATAGAAGGCATCTTTCAAAACTTTACAA ATGAATCTTACAAACTGGTTTTGTCTGTAAACTATGGATCGCGCGCGGTACAAATTGAGTGTTCAAGTAATGGTCAATCTTTGA TAGAGGCTCTAAAATGCGATGATGTCTTAACAATTAAAGATGTGTTGCATTTTTTCAATAATAACATTGGTCGCGAAATACAAT TGATCAGAGTCAAATGTCAGCAAATCAATAACGATTTAAAAAATTTAGTACTGACAAACATATCGTCTATAGAATTGACCAACG AACGTCCCGTAATAATGGACGCGTCTGAGGACATCAAAGTTAACTTGAGCCGTAAGCAAAAATTGATTCATAGAGGCACTTTGC TTTCTTTAAACATTGAAGTGCGCCCGTTTAAAAAAAGTCAGAGAATTATTTTTGATTTTGAACTTAAAGAGGATCCAGGTCATA CACAAAATGCGTCATTCTTTTGTAATGACAGCATGAACGAGGACGAAATTTCCATATTAATGATGAACTTAAATCATTTAAAGA CCATGGTGAACGATATGGAAGTTCACATTTATGAGTTGGGGGACGGGAAAATGTCGACTATTTTAGGCATAACTTGTAAAGTTT TAAATTGTGATGACTATTATTGCATCGATTGTAAAGCGCCTGAAATGTAAAAAAATTTAATCAAGTTTTTTAATAAATATTATA CACTATATTTTGTTTTATTCAACAGGTACATTGGCCGGATTGGTCTTTAATTTACGATAAGCCCGAGTTCTAGAATAGGTTTCT ACTTCTTTATATATTTTATTAAACGTCGTTATAGTATCATAGGCAGTATCTTTAATAGGCTCAAATTCATTAATAAGTTCTTGC TGTTGTTGTTTAATTAAATTAATATTGTCGTTTATGAAATTTTTATATTCTAAATTTTCTTTAATAGTTTGTTCTAATTTATTT CTATCGTGTTGTTCGCTTTGAGCGTTTAATGAGGAAATGTTTGCTGGCGACAACGGCAACTGATCAGACAAAATATCTATTTTA TATCCTAAGTTTTCAATTTCATGTTGTAGTCTGACAATATCCTGGTCCTTTGATGATTGCATCTCTGCATTTTGTACACCTGTC GGAACAGGAACAACTGCAAAGTTAAAACTGTTTGTCGGGTCTACAAATACATTGGGATCTGTTACAGGATAATTATCATCACGT CTTATTCTATTTGCATGTTCGACCTCAGAATTTAATTTTCTATTAATTGCTTTTAATTCTTCGTTTTCAAACTTTAAACTATTT ATTTCTTCATTATAATTATTTGGTATCGACGGTAGCGCGGGCGGTGTATATGCCATTTCAATAGCTCGCATATCTGTTGATCGA TCTTCGGAAGATTCTATAACTAAATTTTCTCTATTAGCTTCTATTTCTCTTAATTGTTCTGATAATACTCTATGTTGGTTAGTC ATTGTAGCAATATTTTTCATCAAAATTGGAAATAAATTACTTTCTTGTATATTTTCTAATGGTATATTAAAGTAAGTAATTAAT ATATAACGCAGATTGTATAACATTTGATTATACGAAGTTGTAAGTTGGGATGTTTTGTCGAACTTGAATAGACTAATTTCTTTG CTTGAAATTTGTTGATTTAAGCTGGTTATTTGTTGATTCAAATTGTCTATTTTTTGCTCTTTTGATTTAAGTTCCAGTTCTTTC ATTTGGAGATCACTCTTGTGTTTTTGTTTTAACCGTGTGATGTCATGTTCAAAAGTATTAATTTTATCTTTCTGATTTACAACC AACATATCATTTATAGAGCTGGTTGTAGTTTCTTTAATACTCTGATTTAATTTATTTAACTTCAAATCATTATTTTCTCTTTCT AAACTATCATTTTTAATTTGAAGTTTAGTGTTATTACTTTCTAGAGTATTATAATTCTTTGTAAGTTGATCATAACTAGATTTT AAACTGTTATATTTAATTTGAAGATTATTACTACCCATAGGTACTATCTGTGTTTGTAATTTAGTATAGTCTTTTTTAAGTTGA TCGTACTTGGATTTGTAATCTTCATCGGGTTTTTTGTTTCTGTAATTTTCCAATTCTGTCAAGGCGCTTGTTGTCGATTCTGTT ATTTTTATTATATCGCTTTGTAAAGATGTAAAAATGAATTTTTTATCAAACTTGAGAGCAATACTTTTAAAACTGTTTAATAAT AAAACTATAAACGGACACAAATCCGGTCCCAATGGCATGATTATATCGGTTTTATTTTTAATGCACCTCAATAAAGCTTGAATA TCGTTGTCGTCGTCTTTGTTCGTATTGACATTGTTACCGATTGGCTGAGAGCAAGAATCGTAAAATTGCTTTAATTTTTCAAAC ACTAAAACTAAATTAGAACTAACAAAATATTTAACGTTAATATTTTTTAGTAAATTAATAAAGATAGTAAAATTATTTACATTA GGAGTTAGATTGTTTGTTAATGCATTTGACAGCTCTGATTCTTCCCGCTCATCTAAAGCAATTGGTCGTGTATAGTTATTTTGA ACAGGAAGTTGTTGTTGATTGTTATAATTTTGCGGTGGCATATTTTGTTGAGGAGGCATCATTTGTTGCGGCGGTTGCGGGCTA CCAAAAGCGTCCATGCCACCTTGATTATAGTTGCTGTTATAATCGTACTTGTAATTGTAATTATGAGTAATCTGATTAGGAAAT GTTATTGGTATAAGGGCTTCTTGAACCAATTCGGGTATCTGCAAATCTAATCTCATTTGCAGGTGTGGCCTGTGTTGGCATATA ATAGATCTGACACGTTCGAGCATCTCGTCATTCGATCCTTGGGCTTGACATCGTCTGTTTAGAGCGCTTATTGTTTTCAATAAA GCCTTTGTTGTAGGGTCTTTGTTAAATTGTAGATACGACATGGCAGGAGATATTGCAATTAATCTTATGAAATGGAGAACGTTA GTTAACGGACTAGAACAGACCAAATACAGAAATTTTGCTATAACTACACAAGATGTGTTTCGAATTACTAAAATGATTTACCAA GATAATCATTTGATAGTATTTTTGACGGGCTACCTACTGCAGGAACCAGAGCGGTGTGTGCAATTTTATGTGAAAGGTAAATGT GACGTGTATTCATATAAAATGTGCTACGAAACACATGCCAATGACGAGTGTTATCGTAACTGTGTGCCTTACAAAACTATGGTG ATGCCGGGGCTGAGGCAAGTTTACAACGACAAAATTAATGTCATTAAATACAGAAGAACTAATGATGAAAACAAATATTGTTTG GACAATTTTATGAGAGACATTAATAGAGTTCATATGCAAACAAACATGATGGAGGGTACATACGTGAGATTCACCAAAGAACAG GTATGTGTAAATCAGTGTGTTCAATGTGACATAGAAAACATTGAACAATTTGAAAAACTGATTCAAAAAGTTAATATAGAAACA TTGAACAAAGAAATCGTTCCCGTTGTCGCGTGTTATGACATAGAGACAAACTCAAACGGACAAAGAAAGTCCAATCCTTTGATC GATAACATCATATCCGTTTCAATTGTTGTTCGTCGCAACGAGAAAAAAACTAATATTTGCCTGTATTACATAGAAGACGGCAAT GATGACGATTTAATCTGTAATGATGTTTTCAATGAAGACGAAACGGTAAAAGCTGTTAAATTTCATAATGAATTGGCAATGATT GCAGCATTTTTTAAATTGTTGCCCCTCATAAATCCAGACTATGTACTGGATTACAACGGAGACTTTTTCGACTTGAAATACATT TACGACAGAATGAATGTATTGGCGGAGGAACTGGAAGACTCCACTAATTTAAAGCGAAAAATAATGCAAATTCAACGTTACGAT TTAGAACCTGTTGACATTGAGCGTAGAGAACTGACGGATAAGTTTCAAAACAAAGCCGACAGTCATTATTTCACCTATTACATT CACATTGACCTGTACAGGTTTCTAACCATCGAAAAAAACGATGCCGAAAACTACCAACTCAACACTGTATCTGAACATTATTTA AAGATGAATAAAGTGGACATGGACAATACCAGGATGGTCAAATTGTATAGCGAAAATCGCATGGTAGAGATCATCAAATATAAC GTTCAGGACTGTGTTTTACCCATAGAGTTGTTTCTAAAACTCGAAATTTTAGATTTCCTTTATACTCAGTGCGAATTATTATAC TTGTGCACCGAAGACGCTTTAAGCAATATATCGCACAAAGTTAATGTGGTAAATTTCCATAAAGCTCTAAATAACACGCGCACG GACGAGTTTGGAAACGAACATCCGGACCCGTATTTTTTCAACAAATTTGATTTAAGCGTGACATCAGGCCGCGATAATTTGTAC CGTACACCCGCGACCAATACCGGCAAAGGTAATAAAAGTTTGGTAGATTTGACTCGCCTGAAACGTACACCCGTTTCGGCTGAG CATTTGAAACATATCCCCCATGTAAAACTGTGTGCTCAAAAGCAGATATGCCTGTATAGGGGCGGTAAAGTGTTAAATCCCAAA CCTGGTATGAAAAAGTGGGTCGCTATTTTAGATTTCAACTCACTGTACCCCACAATAATGATGTCTGAGGGAGTTTGCCTGTCT AATGTATTTTTGTGCGATGATGGCAACGTTTATTTGCACAAAAATATAAACGCTATCAATCCCAAGCTGTTACAACAGCTGCTA AATCTCAGAGTCATTTATAAAAACAAGCGCAACAATTATGTCAAAGACAGTTTCCAATACAATCTAAATGACCGTCTTCAAAAT GCTGTCAAACTTATAGCAAATAGTATTTACGGTTACTTTGGCATATTTTTTAAACCGCTGGCCAACTACATCACCAAAATCGGT AGGGGAAAGTTAGGGGAAGCCATAAAAAGAATCGAAGCCAAAAGCAACGACAAAGAGATTCTTAGGAAATTTGAGCTTAGTAGA ATCGAATTTAATGTCATTTATGGTGACACCGACTCCTCGTTTATTCAAGTCGATTTTGACGAGTCGGAAATTGAGGAGGAAAAG TGCCATGACACAATCAAAGACATAATTAGTAACTATGTCATGCGCGACTTGAACGCGTCGTGGTCGGGTTATAAAATGGGCCTC GAAAATATCATCAGCGACATGATTTTGCTAAAAAAGAAAAAGTATTGCTATATTAATAGCGAACGCGAAGTTAAATACAAAGGT TGGCTCGTGAAAAAAGATATGCCAATGTTTATGAGAATAACTTTTAGGGAAGTTGTGGATTCCTATTTGAATCGACACACGGTA GCGTGCGGCCTCAAACTCATGTATAAATTGATGCGAGCTCATTATGATAATTTTGACAAATCCGACAAACTTTTAGATTACAGT TTTAGTATGACCTATAACGAATCCACTGGCACGGGCGCGACCAAAAATAAAGACGGCACATCTCGCAAAAAAGTCATTACTGTG GCCAAAAAGTGCCGAGAGTTTTTGGTGGCGGCCGGTGCCGATTTCATACCGGGCAATGGCGATAGAATCCCTTATTTGCTCACC GACATTGACGGTAAAGTGACTGAAAAGGCCTTTCCTTTGAAATTGTTTCCAACCAGCGATAAAAACATCAGTTGGCTCAAACAC ATGAATATTTTGTGCACTTTTATGAATGAGCTAATTCAGGTATTTGGCGACGACCCGAGTTTCGAGTATTACTTCGTAAAGATC TACAATTATTATACTCAAAAACAAAAATATGATGTTAAACATCCCACTTTGGTTGAAACGATTGTAAAAAAAACCGCTTCAAAG GGCCAAAAAAATAGTTCTTCTGATGAAGACGACGAAGAATCGGGTACAGATAATGATGAGGCGGACGCGGGTGTTAAGCTTAAG CAGTTTAAGATGTATTGTAAAAAACCCAAAAATGTAAAACACTACAAAGGTTCGCTGTGCACCAAGTGTTTTAAAATTTGTTAA TAAATAAAACCGTTTTCATAATTTTGTGTTTAATTTATTTTTATAATAGCATTATTAACCTCCACCACTAAAAACTCTGATAGA TCCCTAATCATATAGTCGGATAGACATTTCTTTTTTACAAAAGACTTCAAAATATCTACAATATTTTGGTTAGAAAGAGTTTGG TAGTATAGATATTCCACTTGACTGTCGCTCAATTGTAAGCCGTTCGTGGCGTCCACAATTGTACATAAATCATATGTGTCGATA CGTTTGTTAAGAAACATATCGATGACGTTCAGCAATTTGTCAAAAAACATTTCATCTCTCTCCAAATCATCATGGTAGTTTTTG ATGAATGTGCTAACCGTGGCGATTTTAGTAGCTAGCGGCATGCCGTTGTAGACCACTTGAGAGAAGAAATTTTTAACAAAATCC ATGATTAGTCTGTAGAACTTGTGTTCTTATTTAAAATTGCGTCGAACGCTTTTTCTAAATCTCTCTTCTTTTTTATACTCTTAG CTTTACCGGTTTGTAAATCGGCAGCCGTGGACTCTGGTTTAATGTAGTAGACCTGTAGCATTATTATAAATATAATGCAAACTA GAAACAGGAAAAATACAAAGTTAGAAAATCCTTCGTTTTTATCAAACAAAAATCCTAGCACGATTAACAACAAAAACGTTGTAT AGATAAACATTTTGACACTTATAAAATAATTTCAGTATTAAAGTAACAAACTAAACACCTTATTAACTGCTGCTATCGCTGGGT GTGGTGGTAGATGTTTCTTGGTAAACATCGTCCTCGTCTTCTTCATCATCGGTTTCGTTTATGCCGACATTAAACTTATTAATA TAGTGTTTGGTGCTGTTAAACGAATCATGGTTCATTAGTTTCGCCACTCGTTGCAATGGCACACCGCTGTTATACAGGTTACTA CTCAAATAATGCCTGATCATATTGGAGCGTGGCCTATCCATATCTACGCCCGCCTCTTCAAAGAGTCTTTTAAAATCTTTAAAC GGCGTCGATGTATTTTTTGAAATTTGCAAAATAGTAGGGTGCTTGATATAAATTTCCCTAGCCAACTCTAGCGGTTTTGTTTTA ATAGTATTAAGTGAATTTGTCCTCGCATGTTTCCTTTTCAAGTTTATAGTAGTACGAATTTTGCCCTTTTTTATAAGGACGGTC AAATCTTCTACGGAAAGATGACGAGCTTCATTTATACGCATACCGGTTCCTAACATGATACAAAAAACTATAGCGCCCCTGATC AGGCCTCGGTCATGGGCGTAATCACCGTTAAGATACTTAATTTTTTTTTCTATACAATCTATAACATTGTCGATAATTTCCTTT AAAACGATATTTTTTTCTTTAGTTTTAATATTTTTAAGCTCTTTGTCACGAGGCAGCATAACCTGTTTGGGAATTTTGTATTCC GGTAGACCCATTGTGTTTGAATAAAAATTAATGGTCAGCTGTAAAGTTTCCTTGGTGACGGAACGCAATTCCAACATGCGACGG CAAAGTTCTTCGGGATCTATTAATGTTTTTTGATAGTATATTGAATCAAATTCCGTATTCAAATCGTGAGTGTCAATTTCGTCT AAATGATCGTAATCGATTAAACAAAAAATTAATTTAATTAATCTTGACTTGTAACTTTTTAAAGTTGTCGGCGCAAAAGGTTTT GGAAACATGTATTGGGACCATAAGCTATTATTTTTAACTTCATCGGGCGTGCAACGTTGTCTGTCTGTGGCCAATTCAAAAATT TCATCGAAACGATCGTGACTCTGAATTTTTGACTTCCAATTATTAAACGTGTGTTCGTTTCTTAACGATGACATCGCTTTATCC GACTTGATTATAAATGATTTTTGGCTGATTATGATCAGTGTAAATAATATTTCTTCTTAATATTACAAAATAATAAATTGCATA CAAAAGTAGCATAACGCATACCAAAGAAACTAATCCGATAAACAAAATGTTTACAGAGTTAGACTTTTCAAAATCATTTTCATA ATTGTTATAATTGGTCAATAATTTTTTTTCAGATTCATAGCTTACGTTCTCGTCAGTTATATCATTGAGAGCTAACTTTAGCGG TATATAGTCAACTTTGGTGCCTATACCCAACTTTTCGTAGGGAATATCAAAATTCATGTTATTGGATATCCGATTGATTATTTT GTTTATAACTTAACTGTTGAAATATAAAACGTCTCAGTGCTTCGTTTTGAAATGCCAACTCTGTCAAACTTTGTTGGCACGAAG TTTTATTTTGAGTAGATGATGCAGCAGCGCCCGCGGACGACGAAGTTCCCGTCATGAATGTCGCCGATTGAAACAAGGTAGGTT TTCGGCCTGCGCGAGTCGCCAAGTCGGCAACATATTGAAAAATGTCCGTGGAAGCGGCCAGCGGTGCCAAAAATCCAATGTTTT CTTTTAGGCTAACGATTCTAGCGCGATTTTTTTCGTTTAAAACATACAAATAGTATTCGCCACCGCCCGCGAAAATATCATCAA TAACATTATTGATAATATCGTTAATCATATTGAGGCCGGCGTACTTGCGGCTTTCCACGGCGCCCTGAATGTTCATAGGAATGT TTGCACGCTGCAATAAAAGTGTCATGTAGCTATTTGTCAATTGCTGGCTAAATGGGAGCGGAATAGGCACATTTGTAGCCACGG CTTCCGCCACTTGATATTGGATCGCCAGTCCAAGTTGGCGAGCGGCTTGACTCACGCTGTTGGCATTAATATTTTCGGCGTTGT TGTTGTAAAATTTTTGTGCGTACGATGGAAGTACGCTGTAAACAAAAGATGGTTGGAAAATGTTATCCGTCACCACCGAATGAC CGAGTTCTTTGCGCAGACGCGTGTAGTGTTTTATTAAATTCTCGTCGTTATCAAAACGTTTGACAACATTTACATTGATAGGAT TGGAATCGATACAAATGTCGCGAATCGTGTTGACCAGCGCCAGCATCTGAGGCGTGAGCTGTGACATGTCGTTCGTGCGGTAAT ATCGAATGATTTTTCCTACATAGTCCACACATTTGTTAAGCCACGCTTCATTGCTTGTGGTCGTCATAGTTTTTAATTTTTGTT ATGTGAGAGCAAAGTATAATTTGAGGATCGCTTATCATATAATTATTGTTAATGTACAAAAGAAACATAAAAAATATGACGAAA AAAATATTATAGTACGAAAATTTTAACATGTTTATCATAATAACAAACAAAGCTAAAGCAATAATTATAGTTTGCATACTTTTA CGCTTGCACAGAATGGTTTCGCAATTTTTAAATGCCACGTTAAAATCGTTTTCGCCCTCAATAAAATTTTTAAGTTCGTTTTTG CAACATTCATTACACAAAACCATTACTGATATTACATGACCGTATGAATGTATCTGCTGAAAAGTGCGAGGCTGACTTCCCGGA TGAAATTCGAAAGCATAATTATTATACATATTTACTTGCGCGTAATAATGAGCCAATATGGCGCCGCAACTTTTAGTGACTTTA ACTTTACAAATTTTTATGATATTAACTAAATTCGTGTATTGGTTGTCATCAAAAAGTTCGGCGTTATTAATATCGCCGTTTTCT TTTATGTTTTGAAACTCGTCAAACAAATAATGAATCAACAGTTCGGGGTCGTATTTTATTCTATTAAACCTCATCAAGTTTTTG TCTCTTAGGCGGTCTAGCCAAACAGGATTCGTCGTTTTCGCTGTCGTTTTCACTGCCGGTTTCGGTACCGTAGGACTGTTCGGT GGATCGTCGTTGATCGGAGGAGTAGTCATCTTTAACAAGATTTTCAACAATCTTATTATTCATATATTTGATTTTAAATATACA ACAATTTTTTTTCAGCACCAAAGGTTTTATATTAAACAAAATCGTGTTGAGGTTATTTTCTTCGTTGAAATTATGGCTTACAAC ATAATCACCGCAAGTTACGGTCTGATAATTAACTAAATTTTCTGTTAAAGGCGCTAACAATTGTGTGTCCAAAATTTTCAAATG GTACGCACCGACAGGTAGTTTTTTTAAGTGATATTCATCTTGAACAATAAAAGATAAAATATTTTCGTGGTCTGTTTTATCAAG ACTGACATAACAAGCGATGTCCATAGTACCATTATTATTATGCGCCATTATATTGATGATAATGTTTTCTATTTTATACTTAAT ATTATACAATGATTTTAATGAAAACGAATTTAACAAAAGGCTTAGTGTTTTGCTGGAATATATGCGGCGTACCAATTCCGAATT ACCTACGCCGGAACAACTAAGTTACGTATCTCACGTCGATCAAAACTTTTACACAATCACCCAATTCTCCACGAGCGATTTAAA CATTACAAAGCAAACATTACACGATGATCGTATCGAAATTTTCGATTTCCTCTCTCAAAAATTTCAACCGATCCAACATAACGA AGAGGCGCGAGTAAAAGCTCATAGCAAATATCATTCTAAATTTATGGTGAGAGGAGACGACGGATGGATGGACGTTGACTGTCC ATTAAACGAAATTTTTGATGAAAGTATCATGCGATGTGTTCCTACTCCAATATGTGACCAAAAATTGCCAGGCAATTATGGACT CACAGAAAATATGATCGATAAACTAGTTCTCAATCACGCTATTATTCGCGAAAACGTAGATGAAAATTTGTTCCATCCCACAAT GTACTTGCAATGTTTTGATGGCGGATCTCACGCGGTCATGGAATGTCCAAACGACCACATTTTTAATGCCACTACTAAAGTTTG CGAGTTAATAAATGAATGCGAAAATCGTCCCGACGATTTCATACTTACACGATTTCCGGATTATTTAAATATTAACGAATATAT GATATGCAAAAATGGCGAAACTAAGATCGTGTCGTGTCCGAACGGTAAAATTTTCGACCGAAATCAACTAAAATGTGTGTTAGG AAACGCGTGCGAAATTAACGGCGTCGGTTTCACTTATATTACAGACGAAATTGGCGATTCGCAGTTTTTTAAATGTATAAACGA ATCCGAAGCCGAATTAGTTACGTGTATTAACAGAATTTTTCGAAATGACCAATACGAATGTACCGGCGATGTTCAATGTGCCAA TTTCGTTAACGGTTCGGGTACGCAAATAAAAATGTTTGAAGACGATACTTGGATGTTTGCAAACGGAATTTTGATATGCGAAAA TTTTCAAGTCCAAAAAAATATAGATTGCGATTCCACTAATTTATTGCAAGACAAATTGTTCAACGAAAAGTTCAAAGTCAATTT GAATATACCTGCAGAAATATTTGATACCGACTCGGGAATGTGCGTACCCTTCACAAAAAATTTAATCAAAATTAAGAATGAAAT TTTCCCCATCGAAAATATTAATAATGATTACAACATAAATTTTGAAACAGCCATGGTGGGTCGAACCGACGCGGTGGAAACTTT ACTCGAAACTTCCAGTTTGGAATCGTGCGTGTCATTGGCTCGCGATATCGGCGCGGTCGGAATCAATCCTTTAAATGGAGATTC GATAAATTGTTTCGGCGAAAACCTCTATGACATTTTCACCGGAGATAAACTTAACATTTGTGATGATAATCAGCTAGTGAAAAG TGTCGATCTAAACTACGATTTTTATTTTCAGCCAAAAACGTCCAAAGTAGGTCGAGACGATGATTATGAGCGTTTTTGTGGGCA AAAAACTACAAACGCTCAAAAAATCGTAGAAAACGACCTTTTTTCGGCCCGTATATTTGCCCATATACTACGATCTGATGTTTG CGGACTACTTATGGCACAAATATACCATTCATATACTACGATGAACCGAAAATATACTACAATATACGTTCAATATACGTACGA TATCGAAAAGAGCCCGAAAAATATAGTAGTATATGAGTCAAATATACAAAATAAAAACGCTACGATGCAAAAACGAGGGTCGAC AGCAAATGATATTTTTGTAAATCGAGAAATCGTTGATGGGGAAAACGATGTAATCAAACCGCTTTTCGACCCATTTGAGAGATC AGAAATTCAACCTATATTTAATCCATTTGATGTCGCGATTCGTCCGCCGTTATCGTGGTTTCCGGAGTCTGAGCCCGATATTGA ACCTGAACCCGAACCCGAGCCTGAGCCTGTACCAGAATTGATCTTAGCCGACAAGTTATTGGATTATTCTTGTTTCTATTCATT GCCCACATACAAATTTAGTGAATGTGAAATTGCCAACGATTTTATCGTTGATAAAATTAAAGAACTTCGCAACAATATAACAGT CGATCCTGAATGTGAAAACGCGAGAGGATTGTCTAATGTGTTTAATTCATATGTGTATCTGGGTAATGGAATTGGATGCAAATG TCGCTACGATGATGAGAAAGGAATTATCGTTGAGAAAATTTTGGACGGACCCAGATATCTAAATGTTGAAACTCAATCTAACGA CGGAGTAAAATATAATCAGTGGGTACATAAAAATGGAAACACATTTATTGCATGCCCCCAAGAACTTCTCAATGATAATTTCGA TTGTGCCGTTCATTCCGACAAATTTTACTATCTAGAGGATTTGCATGAATAAATAACAAATTTCATTTAAACATTTATTATTTA TAAACCAACATTTATTATTATAAAAACCGACCCCATTACAATAATCTTAAGATTAAAATAAACAAAAAAAAATACATGACTTAA ATCTTATTACAATAAAGACTAAAATAAAAATTTATTTTGAAGTCGAAGGTTCGTTCGACGCAGCACGTCCCGACAACGCAATAT TGGCTCGAGTAATACGCAAGTTAAGATCGGTTTGATATTTCAACATGTCTTTTTGAATCATTACTTTATGCTGTAGATCAGTTA TTTCTTCCTTCATAAATTTTTTATACGATTGCAAAACATTCATTTCTTTTTTCATTGCAGCAATTTTCGTCTCGAGTTTTTTGA ATTCCTCTTCTTTAGACTTGCACAACTGAAATTTTTCCATAGCAAGTCTCTTAAAAACAAAATCATATTGTTGTCTCGCCTTTA ATTTTTTTTTCTTTTCCGTTTCTATAGATTCTTTAATTTTAGTTAATTCAAGTTTGTGCTTTATAATCTCACTTGTAAGCGAGT TAATTGTTTGTGATTTAAATTCATTCTTTTTAGTGTTGTTGTTGTTACTATCGATGATATTTTTATCGAACAGTTGTCGTGCTA TAAGAGCAGTATTAAATTTAGGATCCAGAGGAATAATCACATTTTTGATATTTTTAAGGTCAATATCAATGGTAACATAATCTT GCATGTTAACGGAAAAGATGGTGCCCTTTTTAGACGATTGTCGGCAAGTGGGGCATTTTATTTCCGATAGGCGCTGTGTATTTA CATTCATTAGTTTGTAAATACACGGCGCACAAAAATTATGACGGCACGGATCCAACCGTATCAGCGGCAAAATACACATGTTGT CCACACTTACGTCGTAATCGTCTTCCAAGAGATGGCTGCCGGTGCAAATATGGCAGCTAACACGAGCGATATACTTGGTATTCA TTGTAAAAGCTTGTGTTTGATGCTTACGCAAAGGCAGATCACAATAAACTGATTTATGTATGAAATTGTTTTCTCTTTTATACT CATGTCACCACCGGTGCGGTCGCAGGTCGATTTACCGGAGCAGCAGGCATTTCCGCGTCTGTGTTAATACTTGTAGACGGAATT CTATCTGTACTGAATGTATTTGAATTGTAAAATTTACGAAACGGTTTCTCTTTGTTAGTGTACAACGTTTGTTTTCCTAAAATC AAAGGCACATCAATAGAATAATTGTCGTAACGTGCTAGAGATCTCTGTAAAGCGTTGGCGTTACCCTGAAATTTAAGAACATTT TCGACGCGCAAAATATTTTCGTTAACATTAACCCTGTGTTTAGGTTTAACGGGATTATACAATGTGACATCTGCAACTAAGCCG GTTGAATCAATTTTACACGTGGGACAGTTTCTGATACACAAAGTTTCCGTATCGATTTTTATAATCTCTGGAGCGACAGCTTTT TCTATTAAATTTTTAATAAAATTGGGCAGTTTAATAAAGTTTTGGTCGCCAATATCATTTTCATTTTCGTCCGCGTTGCTGTAT AGTCGGTTATCGTATGCTACTCTTGAGCAAAAGACAGTAGGATCCGTCATATTGAGTATAGTCATAGTTTTGCTGTATACTTCC TCTACTATTTTGTATGTTTGCTCCCTATAATTTTCGTTGTACTGAAGTATCTTGCAAATGTTGTCCTGGTTAGTTTTGTCACCA TAAATGATATATATTATTAGACGTTCTGCCAACGGTAAACCTTCCACATTAAGTACGGTTTCGTAGTTTTTGTGTGAAGGTATT AAAACACGCGCATTACCCATTTCTTTGTCTCCCACTAAACTTCTGCCTACTGTTCTGTAATAAATGTTATTGTCGGCATCGGGT ATGGGCAAAACCATTTTTTCGATTTTAAAGTGCACGGATGAATGGTATTCGCAAATAAACCATCCGTCGTCGACGGACGAGTCA GACGAGCATTGATTCCCATACCGAAAACACGGGTCGAAAGATTGAACAGCACCAAATATACAATAATTTCTAAGTCGATTACTT GCGAGTCCTGCCGGTACCAGCGCCATTATGGAAACGATCGAAAAAGAAATCTCTTATTCAATAAATTTGAGTCAGGATTTGCTC TATTTAATTTTAGATTCTTATATTTCTAAAAAGTTTGATTTCGTGGGTAAATATTATGATTTTGTGGATACGAATAACGTGCGA ACACGTTTGGGAGACAACGGAGCGGTGTCGTGTCAAACTAAAAATGTACAAAACATGGAAAAGTTTGTCTTCGCCGATCGAAAC GTGATCATACCTTTTGTTACAAGAATCAGCAATGAAATCGAAGTTAACATTGAAAATATTAAACCTGAACTCGACAAAATTGTA GAGTGTCGCGTGTACACCACCAAAAAATACCCAAAAATCGAAATCAAGTTTGAACAGATATATTTCAACAGAAATTTAAGCGAC CGCTTTGATTCATTGATGGCAAGCAAACAAATTGCTCTGCTAAATCTGCTTCAAAACCGAAACGAAAGCATCGTTAAACAATCG TATTTGGGGTCTGATGAAATTCTGGCCAATCTTCGCATAGAATACGAGTACGACGACGGGCCGAACATGGAAACAATTAATGCG ATTGCCGAAATTGTCCGCGAAATGGACGCCATCAGTCACTACCAAAACATAAGTCCCCTAATACCGTACACGACGTTACAAAAC AATATTATTTACAGAAAATTTGAAGGCGAAAAATTGATATACAATTTGGAGGACTTGACGAACGTGAAAAAATGGGCACTAAAG TTGGACGGTATCAGAGGTAAAGGATTTTTTACTCGCAACTTTTGCATAATATTTATGGATGATATGCAATTGTTTGCCGGCCAT TTTCCCACACTGTTCGAAATAAATAATGTGGTGGCTTTTCAATGCGAACTTATAGATGACAAGTTATACATTACAGATTTGTTG CACGTGTTTAAGTATACGTACAATAATAAAAGCCAATACGAATGTTCGCACGACGGCTACAACATCGATCCCATCACTGCCATT AACACTATAAATTTTCTTAATGGCAAATATTCGAATACAAGTCTACACATTGAAAACTGCCACCAAAACAAACTAGAAATCAAA TTTCAAAAATTTTACGATCCACCGCTTCCCACGAGTTTGGGTTACACTACAATCGCCACGGACGGTTTCGTTGTGTTGGATATC ACTTTACGCTATGTAAAGTATAAACACGTCAAAACTATAGAATTGGAATACAATGGCAAGGAAAACTGCTTTGCTACTTTGGAG AAGCTATTGACGAATTATAAAATTAACAGCAATATCGAACTGATTCACAACAATATTTACGAAACTGTCATAGTAGATAACGTT ATTACCGTAATTAAATTTAGACCCGATCGTTTAGTTCCACAAATGATTCATGATGAAACGAAAATGGAATCGTAATATTTAATA ATCAAATTATAAAGCAACTTACGAAAATTGATACAATTGGACGAAAAGGGAGAAAACTGGTTTCAAGTCAATCCTTTCGCCGAA GTTTTAAAATATAATAATAATAATCCTAAAGCTATTACAACACGTTAGCAAAGAAAATCAAAAAATGTTTGAAGAAATGTGTCT ACCCGCAGCGGGCAGACCGATGAATCATCACTCCATCCTGCGACGAAGTTTATCAATCGTGTTTGTAGCGAAATTTTCGCTGGC AGGATGAATCCATTCTAACATCTATAAAAACCTGACGCGCTGTTCGTAGCTCATTATATCGTCAGTCATTGTTTCGTAACAAGT AAATTTCGTTGCATTTTTTTTAAAAATGTCCATTTCTAAAATCGAATTTGTCAACGGACCGATCGAAGTTTTCACTGTGACTGA CGAAAAGGGAGAAAACTGGTTTCAAGCAAATACGTTTGCAAAAACATTAAATTATAAAAATTGTCCCAACGCAGTTGCTAAATA CGTTTCTGCTGAAAACCAATGTACTTATGACGTTTTTAAGACAAATAACGGGTCTCCTCAAATCGAGGAGACTCATGAATCATA CTTGTCTATTCAACCCAAAACCAAGTTCATCAATCGAGCTGGCGTGTTCGAACTTTTATCTGCTAGCGAAATGCCCGCTGCGAA GAAATTCAAGCAGTGGAACAATAACGATTTGTTGCCGAAATTGTGCGAAGATGGAGAATATAACATGGCTAGAGACGCGCCTAT TGAAATTAGCGAGGGAATGAACGCTATACATGTAGCTACCGATCAAGACGGAAGAGAAGCTGCTTGGATCGAGGAAGCCAGGAA GTTTCAAGCCATTATAAAAGCAAAGGAACATAAAATAGAAGAGCTGACAGTACAGTTAAAAGATTCAAACGACAAATTGATAAC ATTTGCTACTGGTTTAATTCAGGCCAACAATAATTTAAACGAAGCAAATAAAGGTTTGATTAAAGCTAATGAAACTATCGGTCT AATGGCCAACCGTATGGCCGATATTTCCCAGGACGTGATCGCCAAGCCGTCGGATCCGCAGCTGTTGCATTCGCTCGCCGTGTG CGCCATCGGAGGGGAGCAATATGCGTTTTTGAGACCGCAGAAGAGGAGTCTACAGAGAAGCTTGAAGAGTCTCGACGTACGTCC GGACGATATCGTCTACCAGAGTGACTACGTACCCAACGCAGTGAACGTTTTAAACAAAATCAAAGAGAATCTTCCGAAGGACAA GTTTAAAGCGCGTCACAACAGAATCACTCTGCTGGACGACTTGACTCGCGAGCAATTAATCGGCGTGATCGACTCTACACTAAG TTCCAGACAGGTGGCTATAGCCAAGCGCAAGGTTGAAGAAAAAAATAAATGATGTATTTAAATTTAATAAATATTCATAAACTT TATTTTTACTTTTTATTTTAATTACTACACTATATTCAACAATGATTTATAGTGTTCCCAGTCCATTTTTTCCAAGTTGGCAGG CGGCGAGATATTTCGCTGCACGAATCTGTAATCGTTAATGTGATTATGGAACGCCATGCTAGAGTATAGAGTGCCGTACTTCAT GAGTATATTTTTAGTGACATTGGCAGGGACAATATCGTTTATTAATAGTATTTTGTTGCCAAACTTCTCCTTGTGCATGGCAAT CTCTATACGTTCCAAAGCGACAATCATGAAACCTTTAACACTAAGATAATGGTCTCTGCACATGGGGCAGTTTAAAACGAAAAA TAAATTATAATAAATGGCCTTTATTTGTCTGATGTGGTTTATAATTTGATCATGTTTAAGTTTGTCCCTGTTATTAACCATATC GTCTACCAAAAGACTGAGGAAATGAATAAAGTCCCAGATGCTGGTGAACGTGTAGGTATAATCGTTTGGTTGAAACGCCCTCAA ATTTAACTCTACCATTTTTTCCTGGAAAATTACTTTCATGTGTTCTAAATCAAAGGCGGCGTCTAGTGAAAGGACCCATTTTTT TATTTCGTCAATCTCATACTTTTGTATGTCCTTGTATGTTATGATGCACGCCAACTCGTATAAATAAGTTAATTCGGTGCAAAG TATTTTGGTCAGCTGTTTCGACTTTGATGTTCGAATCCGATCCAAGTGCCGAAAAAGGTGCAGCAAAAAACTGTTTCTGTAACG CGACAATAACAGCGAGGGCGGAATCATAATGAAAACTATCAACTTATTTTTGCACGATATGCCCCCCGGCGTTCAAAATGACAA AGAGATCGACGAAAATGTAATATTTTTCGACGGAGTGATCGAATGTGTCGAGGACGATCACACCGACAAATATTGCGCGCTGGC AGAGTGTGAAAAAATCAATGCCTTACTAATGCAAAAGATCGTCGTGGATTTGCTGGAAAATAGTAACGGAAACTATTGCAAGAA CCATGTACTCATCGACAGTTTGCTAATGTATAAGACGTATGTAGAATTGGTGGACGAATCGGCGTTTGGTGAAAATTTTCTGGA GTCGTGTGTCCTACACATTACTAGCATTTTTAAATTGTTTCGTGCTCAAAGCAGAATCGTAGTTCTTTTACCGTCCAACATTAA TTGGAAACAAGATAATTTAAGTGCACTTTTGAAACATTTATTACAATTATCTTTAATTGAAATTGCCTAAAATGACGACGATAA TTTTGATTGTAGTGGTACTGGTGGTTTTGTATTTTTTATATGTCAACAATAAATTACCTCTAAACTCTCTCAACGAATCATCGC CTAGCATTAACCAAAGTAGCGATTCGGTTCAATTAGATCCGGCCACCGGTCAGTACGCGGTAAAACTAAACAACAGTAAAATTA AATCGTTTAAAATTTTGCACGGCGACAATCATCTAAGTAGATTGTATGTGTCTGAACGGCCGTTAACCTACAACGAAATTATTG ATGAAGGTAATCGTACCGCTGCAAACTCTTATGTGTTTGTAGGCACAGTATCTGACCCCGCCACTTTGGCGGGCGCAACTTCAA CCAGTCGCACGACCTTAAATTTCAAAATTGAGCAGTTTAAGAATGTATTCCTAATTTTCAAAAACTTGGACTTTAACAAGATTA AAGAAAGCGTTAATATGACTAGATATGAATGCGAAGGCATGGTTTATTGCCTAATAGATCCAAACACAAGTACCGTCCCAGATT TGAGGGATGTTTCCTATCCTATCACCGTTTATACAACCAATGTCAATGCACAATTAAAACTAAAGGAGTGGGATTATGCAGAGG TGAATGAGGCGGGAACCCTATTCATTAAAAATGAAAAATCATTTAGAATTCAATAAACTTTATTACTCAACACATAAACTGAGG CCTAACCGTTACAAAATTTTTCTTGTCCCTAACCATGGAAATTTTTTCATAACACATTCCTTTTTCGTTGAAAAATTTGGCACA TTTGTTTTTAAAATCGCCTTGAATCTTTTCTATTTTTTTAGGCAGACCCGCCTGGGTTTTACACTTGAGTTGCTCATGAATCAT GGTCTCCACAATGGGGACCGCTAGCGCAATAAGTGCGTTTACAGTTTCCTCGGCAATGGGTTCTGCGTTCTCGTTTAATTTTAC ACTCATCACATAGAAAAGAGCCTTCATAATACTATTGTTAATGTCTAAACACTTTAAGTTGTGTAAATGCATGGGGTCGTTTTG AAGTATGTTCCTGTACAAAACATAGCCATCGTTGTTTCGCCTATACTTCAGTATGTGAGACAAAAACAATTGGGCCCCCTTTCG ATGATTTTGAATCTGAGATCGAATCAATGGATATTTTTTTTCTTTAATGTGCGAATATACCGACCCGCTAAATTGAAGTTCTTC CACAAAAGTATGATCGGTGTAAACTATACCGAACCGATTGCGAACTCCGCGATCATAGTCGCTAATAAACAAAGGTTTATTGTT AATAATAAGCATTTTATAATTGGCTTCGTACTTTTGGCTACCCTGATACTTGCGGCATATTACATTACTTTTGGTGGAGTCGGA ATTTGTTTTGAAAAAGGCATCGTTACACACCTTCATTTCGTTAATGACATAAAGTTGAGAAATCAACTTGTCGGCTTCAATGTC ATTGGTTTGCTCTTTGGTCAACTTGTATTTGTCAGAATCATGTTTGTGTACCACAAACATGCTTTCCATGAGTTCAAAGAAACT CGATTTTCCCGATCCTGCCATACCGTTCAAGTAAATGCAAAACTTGTCATAATCTGAGGGGATAGCAAGACTGGTAGCGAAATA AATCATGACTCTGGAGTTGACATGATTGAAGCCCGTTATGTTTCTAAAGTGTATGTACGCCTTCACAATGTTGGCCAGGGCAAT GTTAGAGTAATGTTTGAAATCAAATTTGTTTAATATCAACCTAATATAGAATCGGGCACACCAGTCGTTTAGGTTGTCTCCCTG CCTGGCAATTATCAATTTGTCCCACCAAACATTGTAGCGCTTTATGATGCGTTTAACAAATTTGTAATGTAAATAAAATTTTAC AATAGTGTTGTCCTCCTCTTCGAAATCTTCATCGTTAACAAACGTGCTCTTTTTTTTATTTTCAACATGTGCTACTATATTTTT AATGAAAATATTTGGGTCATTCATTTCATCGATAATGTCAGTGATATAGCGCACATGTTTAAATTTTGTGTATAGAAAATCGAT AATTTCCCTTCGATTTTCGTAAAAGTATGTTCCGTAATTATTAATCAAATCGGAACTTGACACAATCTTTAAAGTTTCAATATA CAAATCAAAGTTGTACAATAGAGACCAAATTAACTCTATAATTTCTTTAGAGACACTAAAAATATTAAATATTACAGCCACCAA AAAAGCGTTACGATTGATTTCAAACGTTGTGTAGCAATCACATACGTTTTCAACGTTAATGACGCATTTTTTACATTTAAAATT TTTAACAATGTCCGATATTTTTTTTTCGTTTACATACATTGACAAAGGAATAAGTTCCTTGTCGTCATAGTTTAAAATCTCAAG AAATAGCTTGTGCAAATTAATTTTTTCACTCATCTCTTGATTAGCGTCATTGAGCGTCATGGCTATAGATATGTTACATTTAAT AATTTTAATGTCTCTACATATTTTTGCTACATGATATATTCTGTATATGTCAACTTCGTATTGGCTGTTGTCTTCCATGTATTT AATAATTTTTTCCGACAAATATTCTGTTTTTTTACGTTTAGTAATGGCTCCTAACAAAGTGTTACCCAAAATAAACGGACAACT ATCGTGATAGGAATTTGTGAGGACATTGAAGACACCTTCCTCAGTGAAATACATGTACTTCCAATTGTTGAATTTTATGGAAGA CATGCTAGATTCGGGCTCTTTAGAAACGAATTTAAAAATTTTGTCATCTTTATGTACGGCGTTGTTATACTTGGTGCCGTTAAA CATAATTATACAGTTTGAAGTCAGAATTTTTTTAAAGTAGCCTCGCGCCAAAAGACTGGGCGAAGCACCGCAATTTAGGGCATT ATCTGCTGTGTACAACCATTGTTTGGAAGTATCTTTTTCTGATTTCAACTTTAAATAAATCATATAGTGTATAGTGTAAAAATT TGCCAAAGCAATTCGAGGGTCTTCCGACGGAAACACTGTCCATTGGTTACATAAACTTTGAAACACCTCTGGGGACAACTCAAA ATAGGGTTCACACTTTGCAACGGCTCGCTCAAACAGAATATTATCGCAAAAAAAATCGTTGTTGAACAACACACGACACACGGT TTCTAAGCAATATCTAATGTTTGTCTTGTTAATTTCCACTTGATCAGACATGGAAATCAGTTTCCAAATTAAAATTAAAAGGTA ATCGAAATTAACAAAGTCACTTTTGTCAAAATATTCCAACAAAACTGACGTCGTTTTTTTCAATTCGTTTTGCATTGTGTCTAA CATTATATTTATGCAACCGTTTACTATTTCGTTAATATAATCTTTATGTTCAGAACTTGAGGTGATGTTGTAAACGATTTTTTT ATATTCAATTTCTTTAGTGTCAACATAAGTTTCAAAGTCCCTATACAATCTTAGATTTTTCAAATCAATATTAATAATGTTTTT GTACTTTTCGGTTACAACACATTGACGCAAAGTAATGTCTTCTCTAATTACATCAAACAATTTTTTGTCGGAAAAAACCAAAAC GGGCAGCACTTTACAATAACCTACAGTACCGTCCGCAGTGATTATTTTGAACAAATCGTCATTTTCTTCTACGAAATCACTATT GCCGTTTACAAATAAAAAACCTCTACCTTCTATATGTAACGACATTTCCACGTTGAGAAAAAATTCAGCGTTAAAAACAAACAA GTTTACATTGCCGAGTTTATGATTATGTATCAGAGGTATGTAGTCCCCAATGTCTATTCCGAAATTCATAAATATGTACTGACG CCAGCCAAAATAAGAAACGTCAATATTGGGCCAGTAATAATAGTCTTTTGATTTGACACACTTGTTCGCGTACTCGTTGTCACC GACACATCGCACAAATTTGCTAAAGTCCACTTTATTTTTGATAATTTCATAGTGTTTTTTGTTAACAAAAGGTTTCACTGTCAC CATGAAATAGTTTCCTTTCACGTACCAATCGTGGGGATCTACAGAAACACTATCTTGACAATAATCCAACTTGCACTGAGTATT CTTATCCGACATTAACTCCAACAGTTTTTTAAAGTTACTGTTAGACTCTACAACCTTTGTTACTCCAGTTTTGGAGTTTTTTAA CACCAGGTTGTCAACAGTATCAAAATTTTTCATAATATTTTCATCACTGGTTTCGGCGTGAAAAATGGTATCAAAAATATGGTC CACATTTCTAATCGGTTCGGTGTCCATTGTGTTAATGTTACTGTTAATGGTTGTGATTTTTCTTTTAAACCCTATAAATGTAGC TGCTGATAACGTTATAGCTAGTCATGCAGATAGTTTGCACTTTGGGTCTTACGTTGAAGTTTTCGATTTGAGTTTTAATAATAA TGTAGAACGTTTGTTTCTCGTCAATCCTGAAAACATTGTGATTTATAATAATAACGGGTTAATATTTTATTATTTGGATTCGTC CAGCGTATTATGTCCTCACGAGTTTTCTTTGCTACGTCTTTCAAAATCCGACATCAAATCTATAAACGAAAGCGGTATATTTCC GACAGTTTGCACTAATGTTAACGCCCTTTCATTGCTCGAGCATTTTTTAACACTAAAAAATAATGTTCCCGATCATAGAATCGT GTTAGCTGTAAACGAAATTAGCTACACCATTTTAGATATAATAAATATGCTAATTTATTCGGGATACGTTTATTTAGAATAAAC GTTTTCGTAGTTAATAATGTTGGACATAATTGTTTCGTGCCAATATTTCCAATCGTTTATAGGTTCTTTGCATCGTTTCAGATT AACGAAATAGTCGTAGGAATGATCGTTATAAATCAAATCGTCCACCAAAGTAATGGTTTTTATATAATTAACGCCGAGTTTACG AAGATACCAAAGCGGAATTCGTGGTGACTTTGGAATTCTTTCTCTGGACGAATAATCATTATCCAAATAAAAAGGTCTTTCTAC ATATACAATTTTCGATTTGGCATCAACTATGGTGCGCTTTGACGGTTCTGTCGATTTGTATCCGCCACACAGCACAATATCAAA GAAACCGTTCAATTCAGTTTCGTCCATAGAACGCGAGACGTGTTCTCGACTACCGTACGACCATAATATCAATATACAGCCAAA TTTTTTTAATCCTTCCAAGCTTTCATAAACGAATTCGTCTCTGATTCTAACGCGGTCTTCGCTCGTGATCAAGGTTTCGTCCAT GTCAAAAACTATAACATGCGGTATTTCCCACACATATTTTTGAGGCTCCATTTGGAAAACTTCCAAGTAATTTTGAACGTACCA TTCTTTTAAAAAACTATACATGGGCTTGCGTTCATTTATAACATACACATGACCGAGTGATAACGTTTCAAAAGTCATTTTTAA ATGTTCTCGTAATTCCTTCATATTATCACGACATTTAATCAGTCGGACTATGTAATTGTCGGTGTCACATTTGTTGCTTTTGTC AAAAGCAAACACTACATACTCGAAAACATTCAAATGTTTGAACCCGACAATGTTAAGGTCGGTATATTCGGCAATGACAAGAAT ATGCCGCTTCATCAAAGGATTCATGTGCCTCAAAACTGTCCAAACAGCGGATTGTTCCATTGTTACCACTTATTTTTAATGTTC AAAGAGTTTCGAAAAAATCAAAATTACGAAGAACTCATACAATTTCTCAACAAAAACTTTCCCGCTAATGTTAAAAATAAAACA TTTGACTTTTTGAACACGGGACACATGTTTCATTCCCTGTACGCTTACGTGCCATCGATTAACAATCAACAAAAAGAACGAAAG CAAATTAGACTCTCTGAAGAATGTATTAAAAAATTATTTGAAAATACAAAGAATGACATCGAAATGTACCAAGAAATATTCGAT TTGATGCATCAAACAAACTCTGAGTTCGAGTGTCCTTGCGAGCTGCTGATGAAGCGCCGCGAAGAAATCAAAGCGTACGTGGGC ACGTTAGAGCAAAAGGTGTTTGATACTAAACCCGTTAAATTAAAGAAGGAACAAATCGATGCAATTATGAGCAAATACTCGTTG GATTGGAAGAGTATATTAATCAAAAAAAAGGGTAATGAAGTTACCAAAAAAGGTGTTAAAAAGAAACGTAAAATAAAAAAACGT ACTATAATGAACGACGAACAAATTTATTTAAAAATTAATGTCGAAAACAAACTTGGATTAATAAACGGTATGTCTTTAAGCAAA TGCAGTCACGAATATGTTGTCGAGGAAAGGCAGATGCGCGCCGGTGATGAAATTGTATCTTTTGTCAAGTTATGTCGATTGTGT GGTCGGCAAAAGTTTGTTTAATAACGACGATTTCGGTATCTGTATGTTCCGCTACTGCGACGACGAGATGATCGGCGACGTCCT CCGCTCCTGCGTCGTCCTCCACTCGAGCGACGCCTGCCTACAGAACGGCGGCGAGATGTACGTCTTCCACGAGGACGGCCCGGC CGCCGCCGACTTCCGCCGCTGCTAGTACTACTACGTCTTCTGCCTCCATAACTTCTGCGTCTACCGCCTGTCGATCTTCGTCTA TAAACCATTATAATATATAATATATAGTAACCGAATTTTTATTTGCACCTTATAAAATCCATTTATTAATTGTACTTTTTACGT TTAGCTCCTTTGTCCGCTCCCAAATAGACATTCAAACTATCGGACATTTCTAAATGTTTTAACGTGAGCGCATCACTCTCTTTG GTGCACTCCATGATTGTGAAAATGTTGTTATAGTCATTCACATCGAATTTACAATTAGCAACCGCATAGTTTTCCATGCTGCTG TAAAATATACTGTTAGCGGCGTTGTAAAACATTCGAGGAATAGGAAAATCGGTAATCATATCAAACAGATCAGTAATAAATTCT GTATCATCGCAATATGGAATTTTACTGCTGTTTAAATCGTTGATACATTGGTTAGAATCGAGATTTTTAATAGACTCTGAACGC TCAATAATTAAATCGTGTAAAGTGCAGCGTTTGTCTTTGGTCAAGTTGGTGTTTTGAAGCACCATGATGCGAGGGAAGCGGGCC AACGGGTATTTCATCGTTTTTATCATTGTGCTTCTCAACAGCTTCACGGTGTTCATGTCAATTGTCGAACCGGGCATTTCCATT AACAAACGTAGTAAATTTACAATGTTGTACTGTTGATCAGGCGTCACGTAAGGAGAACATTCCACATCGTCGTCCGCCAGGAAG GTTCCTTCTAAATACGCATACAGCGGTCTATACTTTGGTATTCTTGATAAATATATCATGCAGCAAATCAGATCGCTAATTTTA AACTCCACAGACGTGGTACTAGTTAGTGTATAATACTGTAACAATCGCACGCATCGTTTTCTATATTCGTTCAAGTCTTCTATC AAATTATCAGACTTCTCTGTTTGTTGCCGTTGTGAAAACAAATTTAGCAAATTGCGCCGCTGCGGTGCCGATGGCGGTGTAGGC TCGGGCGCAGGCGCGAGTCCCGTAGCCAAAACGGTACTGTTAACATCGGCATTCAAAACAGACTGCCTGGCTACGGTTTCTAAG AAATCCATAAACTCGTTTAGGGAAATATTGAGTGTACTGTTGGAGTTGGATAAAAGCGGAAAAAATTTAGGCCATATTTCCATT TGCATCTGTCGATCGACTTTATTTTTGAGTGTTTCGATTTCCAAAAAAAGCATCACTCCGCTCATGTTGAATGATTTTAATGCT GTTTACTTAATAAGCCTTTTACTCGGTAATATTGTTATCGTAAATATCACTTAGCAACTTTAACGTGTTTATTGTATTGAGGGT ATTCAATTGTATGACGCTTTGTTCGTTTTGAATGGCTGTTAAAATTAACTTTGCCGTTGCCGATCTTTTACTCAAATCTTTGAA AGAAACAACTTTGTTTTCTGACGTATCCGCCATAATTCGCTTGGCAGCAGTTTCTAACACGCTCAGACCGTCCAAAATGTTTTG TTCGTCAAGAGCGTCGCGCACTTGCTCGTCCTCCGAAGGATCGAATTTGCGATTGCGTTTTTTATTTTTATGTCCGCTCGTCAA ATCGTCATCGGACGCCAAAGTTGCAATTAAATCTTCTGTACTAATCATTTTGTAACAACAAGGCAAAATCCTCGTCGATTTTAT GCTTGTTCATTAATTTTCTTATATGTTCTTCGGTAACGATATACTGTTCAATATTTAAATCTTCTTTTATACTTGCCAACTTCA TCATAAAAGTTTCAAATTTCTCATCGTTGTATTTGTTCATAATGAAGCGGCAGACGTTTCGAATTTCCATTTCGAACGGTGTCA TTAATTTAAAATTATTAAAGCAAACATTGTTCTGGTAACCCAGTTTAGCGACCGACGCTTCCATGTATAATCTCAAGTAAAAAC CGGTGAAAACGACCGAAGCAATTTTGTTTATCTTTGAATTTTTTATTTTAGTTTTCAAACACAATTGTAACATGAACTTTTTAA AAGGAGCAAACAGAGGAATATCTAGCGTATGTTGTCCTTTAAGAATGACCAATAACATTTCCAGATTTTTTACATTCATGCCCA AAGTGGCGCGTTTACATTCGTCAATCAACGGTTGTACAGTTTTTCGATCAGTAAACTCTGACGTTTTATCACACAAAATATTTC TGAGGAAATTGACAAAGCAATTTGTGATTAGATCCTCAGACGTGAAAAATTTATTTTCATAGTCGGTTTTTATTAAAACGAATA ACAAAAGCGGTAATCCAAACATGGGCCTCAAAAATATGTCCCATCCTTGCTGTATGGTGGTGTCGAATTGTGTTATGGCGGCGG AAACGTAGTTGGATTTACAAGCGAGGCATGCTAGTTGATTTAGTGAACATATGTTACAAGCCGCGGCGATCGCCGAAATTGATG GGCCGACAATCGGTTTATAGTATTTTTGTAGATAATGCATTATTTCTTTGAAATCACGAACCTGGTTCATAAATTCGTGATTCA GAAACATGGTGAACAGTTTGGTCACATCGCTATTTTGTTGTTTCCTGTTCAAGTTTTGTTTAACAAAATCGATACACTTGCTAA ACTCTGTGTGAAAAGTAAGTCCTTTGACAACGACATACTTTTTTTGGTCAAAGTACTTGGAAAATAGGAACGCTAACGTGTCGA TTTCTTTTTCTAATAAATGAACATTTAAGTTTGCAATTTTAACATCGTTTTCATTTTTGCTGAATTTTAAACTGTAATCAATAA CACCTTTCATTATATTATTTTTCTTTATGGACAGCACCGACCTTATTAGCGATATCAACGATGATGCCCGAGAATACCTTATTA TCAATAATAAATCTATACCGCATAAAATAGTAAAAATCGGTGCTGACGGAGCGTGTCTTTTTAGAGCCATCGCTTTGTTCAAGT ATGGCGATCAAAACATGCATTTAAGAGTTCGTGACGAAATCGTAAAGTATGTTATTGAAAACTGGGACGATTTTTCAAACTATA CATGCGACGAAACTACAAACTGTTACAAATCTATATATGAATACGAAAAATTCATGTCACAACCGCAAACATATGGCAGCACGA CTGAACTTTACGCCGCCAGTATCATTTATGCTATGCGATTTGAAGTTTATAAAGATCAAAAACTTTACGGTAATGGATTTGGAG ACGATTCGTTTCAAATTAAAAGACTTAGGTTTTCCGGCCATAATATGCATGGCCATTTCGATGTATATTTGGCCGACGATAAAT GTGATCCTATACGTGAGCCAGAAAAACAAAATGAAAATAAATTTGTTGATTTGATGTATAATTTGACTAAACGTTCGTACATGA TTAGATTCAACACAGTTCAGGCCATTCACAAATATTTAGTTGAACAAGCGTTGCCTGAACAACAAATGGAATTGGCCGATATCG GGGATAAAATTATTTTTGCCCGAGATCAAATTAACACTGGTAGTTTTGAACTGTTAATATATGAACTTGCAAAAAGATTAAATG AATTATGGTCTGATTTTAGAAGATATTCAATTATAAATAATTTATCGACCAATACCGGCGCTACTGTTTTCGATAGCGTTAAAT TGAGCGATGTTAGCGGCGAAACTAAACGCAAGGAAACACAAAAACGAAAAGTACGTCGACAAAATGATAAACGAGTTATTACAA AAAATAAAAACAAAAATAACACTTTTGAAACCGTATATTCCAATAATGTCCAACCAAGGGACACTGTATACATTCAACCAAGAA ATTTGCCAAATTTAGAAACAATGTTAACAGTCTCAATTTCAGATAGAACAAAGATCGATATAACTATACCAGAACCACTAATGC CGTTCTATATACAAAGTATCGTGGCAAACATACCCACCACCACTACCTACCCATATATTACATATCCTACTAAAAATTTGTCGA TTGTGCCCTCTCGTGAAAATTTCGAAACTAACATTAATATAATAAACGAAATTAATAAATCTATTTTGGATAACAACGTTCATT TTTATGAAATGTTGGAAGCGTTACTTTATTACGGAGGTAACGAAACCGGCCAAGTCAGGGTACTTTGGTTTATTAGTATCGCCG AGGATTATTTCAAAGCGTGCGCCGATCATTTTGATAATTTGAGAGAACAATTTGCTAACGAACCTGATGTTGATCGTTTCATCG TATTTATAATAAAATACAATTTTTTGTGGCATTACAGACAATTCATAAGTACATTAAACTCGTCCATGTTAACTTCGTATCAAA ATCAGAAAATTGTACGGTTTTTGCAATTAACAAACGAATCGGTTCAGAAAAAATTTGACCGAATCAATATTAGATTCGATCTTA ACGTCGTGTATGTCAACAAAGTTCCACAAGTGGTTCAATTGATGATAGGATGTTACTCCAAATTTGGTTAATGATTATCGTTTT CATAGCGGCCCTTGTTATGTTAACTTTGACAAAACTGAATAAGAAAATAATTAATGAAATTGTCTACTTCCAATACAATTTTAT TCCGGAACCTCTAATTTCGTTGGTAAACGTTATACGATTAAAATAACTAAGTTAGTTTTACGATGGCTTGCCCTTTTAACATTA CAGTTTGCATCAGCGAACGTTTCTTTTCTTTTCCCTACGAATATGTGGTACCACAATCTGATGTCGGCGGAGCGCCTGTTGACA ATTTGGTAATTTACGTTCCAACCGAAGAAGACATACAGTACATTAATACGAGCCAATTAACAAACTTTAAATCCGTACTTGTGT ACAGGCAAGAGTTTAACAATGTTCGTTCCGAAACACGTCTCGCAAAAAAGAATACTAGCGCGACGGTAGTTTACTGGAATCCAA TTGTGCCGATCGAAGAAATCGGAGTTGGCGAAACTCGCGTTTTTAGTGTCCTTCTAACCAACGATTTGTTCTTTTGTAAAACAA TTATTGTGGATCATAACACACCAATTTGTCCGATAGAATTTCGTTCGCGTATAGAATACAAAAAATTGTATCCGATAGGTGGAG AAGTGCCTTTGTTTTACCTCAAAGATTTACTTAACGATAACATCAATGATTTTTTGATTTGTTTCAACCGAGAGACCTCTATAA TGGTTAAAATTTTAAACATTAAAAGAATCCTCTCTATTTTTGAGTATCGAAAAGTACCTGCGCGCTACGCTATAAATTTACCCG AACAGGAGGTGGACAATATCTACAACAAATTAACATGGGAAAGAACGCGAAGGCTGATGAAAGGAGATGTTAGTAATAAATGTG TTTATGTCAATCGGCATAGTTTGATGTATGTTAAAAATGCACAAGAAATGTTGGGAATCAAGAATTATTCGCGTTCAATTGTGG ATTTTGTTAAAATATTTCAACCTCTCATTCAGCCCTACCAAATTGTGCCTGATATAATCATCAAACTAAACACGTTAGAACGTG CGAAACATGTCAGGTTGTATTGTAGAGGCGATAGTTTCGCTATAACTTCGTACGGTTCTGTGCCGGGCAACATGCCCGACGACA ATGTCATCCATTTTAATTATACAGACACCAACAATAACAAGAATTTATTCGAAGTTAAGTCTAATTTGTTCGGCAATAACGCTG TTAATGATTTTACTGTCACAGCTGCTCGATACAACTACTTTTTTTAATAAGTTACAATGCGTCGTACTCAACAAACAACGATAA CCGCTTTTGATCAATTACAACATTTGATCACAAGAAATCAATCATTTTACAAAGATTTTCTTTTGTTCATTTGTGTCCTAGTAG TCTTTATAATAATTTTACTCTTTATAATTTTATTATTTGTTCTAACTAAAAACGCATACGAGCGTAGGGAAACTTTTGCTAGTA ATTTGGATTACAGGAATAGGATGTAAATGAAAATCAAACAGTTTATTAATACATTTATTTTGAATCTGTCGAACCGAAACCGCC ACAATCCCTTTCGGTAGAAGACAAGGAATCGCTTTCCACCAAAGTCGGAGTGTAGTAACGCTCAAACACAATTTGCGCGACGCT TTGTCCTCGTTTGAACTGCCGCGTTTTTTTACCGTGATTGAAAAGCAGCACTTTGATTTCGCCTCTGTAGTCGTTGTCGATTAT GCCGGCGCCCACAACTATTTTGTGATTTGCCGCCAGCCCGCTGCGACTTTCGATCCTTGCATACATATTTGTGGGCATTTCGAT GGCCAGTCCCATGTTGACGAGGCAGCCGTCACGAGATTTAATAATAAAATCTGTTGGAGTTCTGAGATCGTAGCCCGCCGAACC TTCCGTCGCCTTTATCGGCATAAAAGCGTTTTTATTTTTTTTAACTTTACAAGAGGTGTTCATGGTTGTGAGTTCCGTTGAACA ATAAACATGGTTTTTAGTAGTTTTTGTTTTTACAATAACTCGTGTCGCAATCGAAACTGCCACTGATCTTTTTTAAAACATCCA TGTTCAAATTCAATTTTTTGATGACCGTTAACGATTTGACCTTTCTTTCGGTTTTCAAAGCACACGACGTGCACATGTAACAAT CGCTAACAAAAATTAAAGCTAAAGGTCCTCTACCTCTGAGACATTTTGCGCCCATGTTGGTGCGGTGTTTTTTGAATCTTTTTT GTACATTCACTGAAATGCCTGTATAAATGCGATTTTGTACATTTCGAATCAAATATAAAGCCCATAGTTTGGTTGTCATTTTGT AAGGGCGAATCGCTAATATGTACGCGTATGTTACTTTTGTAATGCTGGGCGACGAATATGTCAAAGGGGCTATCGCGTTGGCTA AAAGTTTAATTGTGACCGGCACAAAACATGAACTAGTTTGTATGGTCACGAACGATGTTAGCAAATATGCTTTGAAACTACTCT CGTCTTACTACAAAATCGTAAGTGTAGAGTACATTCATTACAAATGTCCGTCAATGTTGACAAAACGCCAAAACCAACTTTACG GTACGTGGATAAATTATGCCTTCACCAAATGGACCTGTTTAAAACTGATTCAATACGATAAAATCATCTATTTAGATGCCGACC ATTTAGTGATTAAAAATATCGATCATATGTTTGATTTAAACGCGCCCGCTATATGTTTCACTGACGAAAGCTATGGGTACTACG ATAAAATCGTTTACGGTCAAACTATATCGTCGCGCGCTATACAAAAGTTCATGCGCCAAAATAAAGTGCTATGCAAAGGTGGCA CGGTTCTTTTCGAACCCAATGTTAAACTATTCGAGTTGATAAAGAAGTTGGTCAATAAATCGAATCCATGTTTGACAAGAAACT ATTACCACAATGGTTTCGATGAACAAGTGTTATTACAAGCCCTCATAAAATTAAACATGCCCATAACGCAGCTATCCATTTTGT ACGCATGGAACGCAGGCACATACCATCGTTTGAGCAAAAACCACGAACCTTTTGTTATAAATTACTATGGCGATCTTAAACCGT GGAATTTCGCCGATACAGATGTGATCAATTACATGGATGTGTTTATTTGGAGGTACTTTTCGAATCTAAATCTCTAGTATAAAA AGCGATTGGCCAGTTTAAATTTCATTCGCTCAACCGACAGCCATCGACGATGTCTCATTATTATTTGATTGAGAAGCTCGACGA TGCCAGATACAACATCTTCACTTCAGAAGACGAACCTCGAAATCATCGAGGCACCATTATCTACGAAAAGGACCTAAAACGTTT CGCGCCCATTTATCTTCGATCTCAACTGAAGCACTTGGATAAATATAAAAATGAAAATGACGAGTACGTTTTGGAAAAAGAGCT TGTCGACAAACTAATGTATATGACCGAAATGTATTATAAAAGTATTGAAAGTAGGCTTTAATAAACGTTTTGAAATATATTTTA TATTTTTTTTGCTAACCTTAACCCAACGAAACTTGAATATGAGTAAAATCTTACTCATATTCAAGTTTCGTTATACTACTAAAA CGAAACTTGAATATGAGTAAGATTTTACCCCAATTCAGATTTCGATAATATATTTTTTAGTATTCGTTTGTAAATAACGAAACT TGGATTTGAGTAAAATCCTACTCATATTCAAGTTTCAATTATTGCACCATATTTATGGCATCATCCAATCGAACTTTATCATGA TAAGATAATCATGTCTCGTGTACAAATTTACAATTTTTTTTAAACCATTCTATTGTTGGGTAGCGAGCACGTACGATGGATATG TGTGTAAAAGAAAACCGACTAAAAACTTTCGAATTATGGCCGGTGAAGTTTTTATCGCCAGAGTTGATGGCTGAAAACGGTTTT TATTATTTGGGACGCAGTGATGAAGTTCGTTGCGCTTTTTGCAAAGTAGAAATCATGCGTTGGGTGGAAAATGACGATCCCGCT TTGGACCATCAGAAGTGGGCACCTCAGTGCCCGTTTGTAAGAAAGCAGGTCGACGGTGACGGAAGTTCCGGCGGCCCGGACGAG TGTGTCGTGAGCTCCTCGCCTAGCATACCCGGCCCTGTACACCCCCGGTACGCCACCGAGCACGCCCGTCTGCAGACCTTTAAG GATTGGCCCATAAGCATGAAACAAAAACCCCACAAACTTGCCGAAGCGGGTTTCTATTACACCGGTTTGGGCGACAAAACTAAA TGTTTTTTCTGCAATGGTGGCTTAAAAGATTGGGAGGACGATGACGATCCGTGGGAACAGCACGCTAAATGGTATAGCGATTGT CGTTACGTTATTTTGGTAAAGGGGCAAGATTTTATTCAACGTGTACATTCCGAAGCGGCGGTTGTAAAAAATTATGTTGAAACA ACCGAAACTGTTGAAGAAATAATTGATGATTCAAAAGTGTGTAAAATTTGCTACAACGCCCCACTTAACGCCGCTTTCAATCCT TGTGGTCATGTCGTGGCGTGTATCAAATGTTCTGTTTCGGTTAATAAATGTCCTACATGTCGAATGCCTTTTGAAACTATTGTA AAACTATATTATTCATAATAAAGTTTGTTAATTATTGATGTTTGTTTGAATTTATATTGAATTATGTTTGGATAAAAGCTATAT ACTAGGTAGGATAAGTAATTTATTAAAATTAACGATCTAACTACAATATAATGTCTGTGTCTATTAAAAAAGTTCAAGACTACG GCGTGCCGGTGCTGGTCGATCCCGTTACGTGGACGGCCTGGGTCGGCGCGGACGAAGTCCTAAATGTTTTACGTTTGCCATCGT CGGTGTTACAATCGATTCCGTTGCGCCATAAAAAGTGCTGGTTAGATTTTAGAGGAGGTTTTAATCCAAACAATAATTGTAATG TTAGTTGCCGGTGGGACACTGGTAAACTTTTCATTGACCTTTACGGTTTAGGATTATTATGTGGTAGAGTAAATTCAAGTTTGT CTGATTATTTGATGACCCAATTTGTAGGCGAAATTTACAGAGATTATGCGCCTGATGTCTTACCGCAACCTCAACCTCCCTTAC CGTTCCCCGTACCTCCTCAGCCACCGGTACCGCCGCCGGGCAATTTACCTTTAGAATTACTGGAGCGGCTTAATAGGCAAAGCG ATTTAATAATTAACGCTTTAAGTCAATTGAGTATCAGTAACTCTAACCAACACTTGGAAATTACAAACCAACTTAACGCTATCC GATTACAGAACGTGACCATTACCGGTCAGCTAACAAGTATACTTGACATTCTTGAAAATCAATTAGGTAATGTAACTAGCGAAT TAAACAGGTTGTTGACAGAGTTGGACGGACGTTTCGATAGTTTTGTAAACACGCTGAACAGCGCTCTGTCTGCATTACAAGATA GTGTTCGAAACGAGTTAACTACAATCAATTCCATACTTAGTAATTTGACTTCGACCGTGACCAATCTGAACTCAACGCTGACCA ACTTGTTGCAAGCCATCTCCAACTTAAACCTTGGCGATCTTAGCAACGAAATCGAATCCATATCGACTACCGTAGATCAAATAT TGAGCATTTTAACTCCCGAGATTCAATCGAAAAAAGCTTAAATAAATTACTTAAGACTTAGAATAGGATATAGGATATAGGATA AGTTTAATTAATTAATAAAAATAGTGTATAAAATTTTTTTTATTAAATATTATCATAGGTTTCAACAACTTTATAAATCTTCTC CACCAAATCATCACAGTATTCGTAGGGTTTCACATCAATAACATTCATGTAATCGTTTCCAATTGTTTCTGATACCATGTCGGC GGGAGTCGTGGTGATTCCGACCGCTAAACATTGGCCGTGTCTGCTCATAACGGCGTCGATTATATCCAAGTTCATGAGACATTT TTCGTATATTTCTCGGCCGTTATAATTTTTATTGTTAGGTATCGAAAGTACGTATGCAATCAGATTCATTGTAGTACTACATCA TGAATATTTTAAAATCGGTTTATATACTACCATTATTTTTTTTTCCAAAATTTACGTAACGCACCTATTGTTATTAAATTATAA AACTAGTATCTTTTTTAACACTTGAAACGATTTTTGGTTTACTACAAACTTGCCCACTTTTACAGTCTGCCACTCCAATAATAC CGCAACCTAACCGTCCACCCGAATTGCCCGTAGTTTTGCTAAGAGGATGATCGGTAAGGCCAAGATCGTCACGATTTGTGTGCA CTACTAAACTGCGGCCCAAAATGCTGTAATTACCATAAAGAGACATGACATTATCGATTATGTCGATTTCGGTGAGCGAATTTG AGGTTTTCGCTTCAATGTTGCCTAAATCTCCCACGTGTCTTTCCTCTGAGTTGGGCGCGCCGTGATTTTGACCCGTTGGGTTAA AATGTTCGCCAGCCGACGTACACCCGTTACTTGTATCGCCATATTCGTGCACATGAAATCCGTGCAATCCTTTGGGCAAGTTCA TAATGTATCCTTGAATTTTTAAAAAGTGCTTTGGTGATTCTTGAATGAAATACACCTCGCCAGTAACGTCACCATCGATTTTAC AAATGGCTTTCATATCTGCAATCTTATCTAATATGTATAAATTGATGGACGAAAACGCTTTTGGCACATTCGTGTTCAAGCAAG CGACACAATGGGTCACAATATTGACAGTGTCATTAATCTTGGCGATATGTACTTTTGCGTCCAAGAAAAATACATATTAGTGGA CGAGAAAAAATATTGTTTAGATTGCGCGGCCGATTTCATCATGGAAGATCACATAGTCTGCATCAATCATGGCCCCAAAAACGA TATACAAGATTATTGTTGGAAACTTGAAAATCTATGTTGGAGTTGCGAGAAAAACGTGTATTCGGTTCATCGACTCAAAGATTG CGACAGCTGCACCGAAGTTGTGTTTCAACTTTACGAAAATGTTGTCAATGAAGGCGCCATTTCTGTAACTCTATAGTTTTAAGA ATAAACATTATGAACGAATTTAGTGTTTTTATTTTCGCTGTACTAGTGTCTTTGTTCATAGTTTTCCTTTATTGTGTTAGCACA GTTTCTAAATTAATACAAACAAAAGAAGCCGAATCGTTTTCGCCGGCTTTAGACATAATTTTTGATCGTAACGGCATAGTCGAT TGCAATCTAACCAAACTGCCCTGTGTAACTTCGAGACAATGTTTAGACAATTGTAGCTCTCACAATTTGGTGGGGTCTATTGTG TGCGATGAGGGATTTTGCACTAGTCGCGATTTAAACGTTTCGGGTCGCCCCGATAATTTCGAGTGCGACAGCTCGTTAGGATTG ATTAAAGTTTTTACCGCCAGCGATTTTACCGTGACGAATTTGTGTGTAAGCACATACAGAGACATTATCGACGATTTTGGTAAT AAACGGCCGTATGTATGTGATAATGGCAATCTAACTATCGATCTAACAAATAGGCAATTTAGCGCGGCCGATTGTGTCTGCGAC ACCGGATACACAAGAATGCTATTTAATCAAACGGCCTTAACTCGTTCTGTACCAGTATGTATTCCCGACTCAAACCTAAACATT TACAGCAAAATTTACGATCAAGTATGAAACAAAGTTTCAAGATGAATTACACCGTTGAAGAATACAAACATATTATTTGGGCGT ACGTAATGAACGTTTATGTACAAAACACAAAACTCAGATCGATATGTTTGCGAAAACCCGACGTAAAATATGTAGAAATGGTTG TTAGATTGCTACCCAAAATGGACATGAAAAAATTGTTACCACGGCTGAAAAACATATACGCGCTGCACCGAGTCGACGAATTGT TCAAGGAAACGGACAAAGGAGTTTTAGAATTAATAAATAGTATTAATGAATGTTACAATGAATAAAATGAAGTATTGTTATTTA AGTCTTTTTTTTTACAATGAACGCAGAACATTTGCTCCTTTCCCAGTATGTAAACATACAAAATAGCATAATAGAACTGCAAAA TAACTACCTGGCCAATAGCAAAAACCCCGCGGTTATTGCCGATGTAATTAAAAAGCTTACGAATATTAGAGAGGATAAGTTCCG TACAATAGAATCTAGATTGAATACAATCAATGCTAGCGAGCGAACTGCCACATTTTCACTCATAATTAAAAATGATAAATCGTA TTTGGAAAATTTTTTAAATGTGGTCGATGCAATTTATTATAATACCAATCACGAAATATTTGTTGACGAAAGTTTAGTCGTTAG TCGTGGAGCGTTTTTAGATGACTTGATAAATTATGGCAACATACTCGGCAAGGAAGATTTGATATATTTTAAATATGAAGTCGA GTTGATAGAATTATTGAATAGACCTTTGAAAGAAATAGACTCTGAAATGCTCGAAATCGACCGCATAGATTGCGCATCCATTAT TGTCAAGGCATTTTTTCTAAACAATATTCCAAATGTGAGTTTTGAGTTTTTAAAACAAAATATAGACAACGATATAATAAAAAA GAAACTTTCGGCGATACTTTCCTATATTGCGGGAGTATGTAAAAGAATTCGCGAATGTAAAAATAACGAAAAGGCTATTTTCAC TACATTTAAAATATTTTACACAGAGCAGAATGAAATCAATGACAATTTGACCGTTTATGGTACGTTTGAAAGAAACAAAATTGA TGTAAATATGATTAGTCCTTTGAAATTTAGAGGGGCAACATCACCTGAAAATTTATACGATTTCGTGTTAATGTATACAGAAGG TTTTGGTTCTGTCGAACCTTTCAATGACACTATTAATTTTGAATCCCTTATGTATTTGACGTATCCAGAATTGTTTGCTATGCC GTATTTGTTTAGAAACAGCACTGATAGCGAACATCGTTTTTACAATTTTCAAAATCTTGCAAAATCCAACACGATAGAAGTGGC GAGCAATGGTGGTATAATAATAGAGGAAAACGATCTGGTAAATGTCGACTCTGTCCTGTATGTGAACATCGCATTAATATTTTA CAAGTTTAGGCCTGAATCTCCGCCCGGCACCAAAAGTTTTCTAGACCGACATTTGAATAAAATAAAAACATGTTTATATGAATA CGCCAAAGTGGACGATACTATTACGGTCTATTTAAATCCTAACACTGCAAATTACCACAACGAAGAATATCAATTTTTAATCGA AATGTTGGCCGTGTTACAATTAGGTTTTTTCATTTCTTACAACGCTTTAACAGAGGAAATACGAAGTAACATTAACGACACATT AAACCTAATACCAGACCATTCTCCGCTAACACATATATACGATAAACTTGTCAATTATAACTTTAACATTAGTGGGGATTCTAA CATGGAAAGTGAAACAGATTCTTTTTTATAACAGTTTAATAATATTTATTCGTAACAAAATTTGCCGGGCCTTTTTAACAATTA CAAAAACTGGCCGTGCGCACAAAACATTGTTCACCCAAACACAATCGTCTATTTGCTCGAACTCGTACCGCTCAAAATCGTAGC GATTGTTGACATAAAAATAGTATTCACCATTTCGACGGCGGTAATCGATAGTTTCTTCTCGAACGTGCAGCTCTTGAAACATAT TGTTGACAACGATCTTTACGTGGTCTTTCATAATAAGTGCGTAGTCCAAAATGGATCTGAACATAGATATCGACGACTTTACCA GACTGTTGATCGCTGACAAATGTAACGCATTAATTGCTGCGGAGCGGATGTTGCCCGAAAACATCCTGGCGATAGTCAAAAGCG CCCGCGATAATTATTTTGACGACCCGTCTCCAAAAAATTACGAAAACATCAAGAAACTTTTTAGTCAAACCAAATACGTAGACG ACGCGGTTGATTACAAGGATTTTAACCGTAGAATCATGTTGATCGCTTTCAAATTCGCTTTGAACAAATCGAAAGAATATTTTA AAAACTACAAGTCGGTGTTGGAGGTAGCGCTCAAACGACTCGACGGTATAAATCCCGACTTGAAAAGTTCACCGCGCGCCATGT TACAACATTACAACGAGTGTTTAGAAAACTTGGACAATCCGCGTAACGACGAACATCACCTGGTCACTTTTGCCAAAGAAATTG CTACAAAAATTTTTATTGAGACCATCGATTTGTACAGTTACAATAATAAAAGTCCATTCGAAAACGGCAACGCAACATTGACAG GTTCCGATTCTGAGTTGCTGGCCGTAGCCGCGGCGAGCCGAAAACGGAAAAAAAATAGCATTTTGACCTACAAAATTGTCGATC CCATTTTCGTTTTGTAGAGTTTAGTTTAAAAATATTTTTTTGCGCTCCAAAATTAACGAACGACACATAACACATTGATCGACT TTGGATGCGCAATTTTCGCAACATACTAAATGACGACACGGTTCAAACAGAATACTTTTTTTGCCGACCATGCAAACTACGCAC ACGAAATCATATTTGGGTGTTTCGGTTGGAACAAAATCGGGCCGCGTTTCTTCGTCAAGTTTTGAGAGAACATATTTACACTTG GGCGAATATTTAATGTGTTCTATCAAATAATCACTTTCAATTTCGGTCCAGTTAAAAATTCCATATTGCAATCTTTGCATTTAA TTTTGTTTTGGTTACAGTAGACGAACCCAGCATTTTCGATTTTATCCATTACGTGTAATCATTGTAAATAATTTAGTATAAAAG AGGAGACAGGTCCTTATAATAAATAAAACACATTTTTGTTATAACTGTTTTTTATTAAAACATATCATTTTCATACTTGAACTT GATTCCGCATGCGTGAGCAAACACCGTGTCTTTGTTTGTCGTACCATTATGATTGTCTCCGCAAAAAAAACTGTTTTTACAATC GATCGAGGGATTCATTTGCAAAAGTTTTTCAAAGAATCCCGTCGATGGAAGCTTGTATTGAATAGTATGAGACATCATAACAAA CATGGGCACGGCAATTTGCTTACACACATCCTCAATTTCACGATCCTTACTAAAATTAGACACGAGAACAATAGTAAAGTCTTG GTTAATTAAATTCGTAAATTTGTAGACTATGTTGTCGTACTTAAACTGCCAATTATTATTAACTTTAAGCATTATAGTTTCGTT TAAATCAAAAATGGCTACTTTATTTTTCAGTATAGGCAAGCGGTGGTGATAAATACTCAAAGAATTAGTAATTTCCCACCGAAA GATTATTTTCAAAATGTAGTTGATTATTTCTTCCTGTTGTTCATCTAGAGAAACCTTAGTGTCCACGATTATTTCGTCGTAATT CATCACTCTGCGCCAGCAATCAAACTTTTCGTTCTGCTTGGTAACATAATCCGCTTCGTGTATGTCCAGACCATTGTTGCGTTT CTTCATCATTTTAACAATCTCGTTTTCACTTCCTTGTTTTACGCGTAAAATTAAAGACTTCCAACCGTCACAAAGCCCCATATT CTTGCAAATTTCAAAGGCTTGTTCCGATTCTTGTTCGGGCATGTCTTGGAACACTGCCGAATACACCAACGCCTCCATGGGTTG ACGATCGAAAATGTGAAAACGAGAATGGTCACGCTTGTATGTTTCAGCGCTCTTGCTGCGATACGCCGCGAAAAGCATACCGCC CACATTGCTGGGGTAATTATACTTGTCGTGTAATTCTTTGTAATCCTCTAAGTGGACACGAGCGTGAGGGATTCTATCTTCCAA CCTTTTAAGGATGGTAGTTTTTGTGGTGCAAGCTACACCTCCCAAAGCGAATAAGTACGACATGATGTGACGGTAATAATGTTT GAAAAGAAATCCGTTATTCTTTATATAGTGTATTAATTATCTATAGTAGATTAATTATATATAGTAGATTAATTATCTATAGTG TCGTCTGAAAGTCAAAGTCATCAAACGAAAATAAGATATGAGTAAATTTTTACCCCAATTCAAAGTTCATATACTATTAAAAAC GAAACTCGAATATGAGTAAGATTTTACTCAAATTCGAGTTTCGACAAACGAAATTTATATATGAGTAAAATCCTACTCATATTC CAGTTTCGTTGTTGATATCCACCAGAGCGAACGTGCGTTATTTTATATTATAATGGATTATAGTGCAAACTTGATTATAGACGG CATATATCTAGGGGAATATGCTTTAGAACTAAACTATATGCGCAAATTTATCCATGACAACGACATCACCAGCGTCCTGTCCGT CTTTGATAGCCCGCCCATTGAAAACATTGCACCAAATTATCTCTACGTTTATTGCGAAGACGATGAAAACGACGAAAACATGGA ATCGCGTTTGGACGACATGTACGAATTTTTAGAGAAAGCCGTTCAGAGGCGCGAAAAAATACTGGTTCACTGCCACGCTGGAAT ATCAAGATCGGCCACCGTGGTCATTTACTACATTATGAAGACCTATCGGAAAAGTTTTAAAGACGCTTTCAACATGGTCAATGA GAAACGGTCCATATGGCCCAATGATCATTTTAAACGCATCTTGAAGAAAAAAATTAACAAATAAACAATTATTATTTGTAACAA ATGTTTTTTATTTAATGAAATGATATTAGCGTATCAATTTTTGTATTCATTTCGTCAATTTTTTTACTATTATTCGTAACTAGT TGAATCGTTTCCATTGTGGTGTTGTGGATTTGGTTTAGGAAAAACATGGTCTCGTTGCGCATGTGTTTTATTTCTCGAGTCATG GTATAGAACTTTGTCTCGATCATTTCGTATGTGTCAGAGAGCAATTCTTTGATGGCGTTTATTTCCTCCATGAGCGAACCCGCA TGCCACAAGTATGCCAACAACAAAACCAACGCCACACACGAATAGTTCATTTTGATTTTTGAATGGGTCCTCTTATTTTTTACG AACAATCATGTCTTTTAGCGATTTAAAGTTATCAAGCATAGTATCATTGCTGTACGCTAGTTTGTTTGTTAAATCGATTTGTAA CGATTTTATATTTTCCAAAGCCAGATTAAAATTACTTAACAGAGTGTTGTGCTCGTTTCTTAGCAAATCACGTAGAGAGTCGGT CCAACTGCTCGAAGAATCATACACGGTTGGTTGATATATCGAATCTGGCGAGTCCGATTTGGGCGCGCCGTTGGTTAGGCAATC TTTAATGTGACAAATTTGACTCTTGATATCCGACAGAGGGTCCACCACTTGACTCTGCACACCCATCATCAAATCGCAAACGAT TCTTTTGATTAGGCTCAACTGTTGAGTGTTAATTGATGAAGCTAAATTTAACGTGGCCAAATATTTACACAGCGTGAAAACATG AACGTAGTTTTTGTTATTTCTAGTGAGACGCTGCGAAGGAATTACATTTGCCCAAAGCACGGCTTTGTTAAATCCCCTAATAGT GACAATGTGTGCGAGTAAATCTGCCGCAGCGCCTAATTCTATGTAACCGTCCCTGTCATCTTCGCCGTTTTCAATTATTACCAC TTCGATACTTTCATCGTTGTAATGAAACCGAGTCGCCTCAGAATTATGAACGGGTGTATTTTTATACATGTCGGTAATGTCTTA TATTTGTACCGGACCATAAGCTAAGTTAATTTGATTTTTTGAATTAATTATTTCATCATGAATTACAACCATCGCGACGTATAT CGTCGCCGCTACGATAGACTTAGCGAAAAATACAATGCCGTGCTACATCAGCACGAAAACTTAAAATCCGACTTGCGCCATTTA AAAATGCAGATTCATGAGGTTTGTCGCAATTCTGTTGGCGCGGATAACGTTATATGTGAGCGTATACTAAACAATACACCCTTG TTAGATAATACTATCCACCCTCGAAACGACTATACAACAGCATTAGTCAAGGACAAGACGCCTCAACGTAAGCACATGTACAAT GACGGAAAGCCGTTGGTTAGTGTGGAACCCTTCGATTAAAGCATCACAAATTGACCACGATGCCATGTATCTAATTTCCATGGA AGACTTTGATGTAGAAGTTTCGCCGTACACCGTGTTTGAGCCTTGCGGTTCAATGAAAGTGTTCATCACGGGTTGTAAACTTTA TGATATGATTAAAGTTTCTTTAGAGAACGAGCACAAAGTCATGTTGAAACGGTCATCTTCCAACGGCGAAGACAGACTTAACAA CAAGTTTATGAAAAAAAGTCATCGAAACGTTTGTTTCAATCGGGTGACTGATAGAGCCAGCATTATAGGATTATTGAAAATATC ATTGAAAATGCCCGAATGTATGGAGAATATTTTTGTGTCTTTGATAGAGTCGCCGAGAGGAGGCAAGCACTACACACGTTTTGT TTTCAATTGCTATGTTTGTAACCTGTTAACTTGCACAAAGTGTAACAAGCGTTGTTTGGCTTCCGCTTTGTGTACTTTATATCA TAATGACGATAAATGTGTTAACGAAGTGGAAAGCGCGCTTTTTAAAAAAGAAACCATCTACAAGCCACCCAACTGTGACAATAT GAAAAGGAAAAAGTTATGTTCGCCTTCTAAGCAGTGTTATGTTAAGAACCCTTTATGTATGTTTTAATAAAAATATAAGCACAT CTTTTTTTGTTTTATTTAAGAGTATAAATAAAAATGTCTTTTGACGAACGAATTATTAGCCTGTGTTCGAAGGAAAAAGATCTG CGATCACAATATGAATCCAAAGTGAATTCGTTTTTTAAAAATAAAGGTATGAAAAAATCTGTAGACATATTGCAAAACGAATTA CACCAGTTGGATGCCCTCATATTTGGTTACGAAGAACAGATTCATTTCCTGAGCACGAACAATAATGTCGCTCGCCAAGAAATG GTGGACAACGTTAACGATTTGGATCATTTGGGTATAGACAAAAACTTCATTGAAAGAATGATCGTGGACAAATTAGATGATTCT TTATTTGAAATATACAATACAGAAATTCTCAACGAAAATATAATTAAAACCTTTAGAAAACATAGTAATAAATTTGTTAAAGTT TTGTGTCAATTTGACGACAAACGAAAAGCTTACAGTAAAAAAGAGTTTAATAGAGAAAAAAACAAGAAAAATATTGATGAAAAC AACAATTTATTAGTAGAATTAATTTTATTAAAATCAAACTTGGTGTTTCATTTATGTACAATGGAAAAAATTCTCGTGAACAGC GCTAACAAAAACATAATCAAAAAAATTGCATAATATTCATGATTTTTGATTTCATGTTTTCAATCTCGTTAATGTCTCCGTATT CTTGTATAGTTGTTATGTTTCCATGTGTTCTTTGCAAAATATATCATAGTTTTTAAAGTTGACAAATCCATTGTCATCCAACGA AAAACAATCTTCGCACACGGCCAGGGACACGTTGGCACCGTGCACAACAAACAAGGGACAAAAGTGATTCTTCAAAATCGTGTC TGCTAAAATCGCATTGTGACCCGGCAGCTGCGTCTTGATTTCCAGTATATATGCGGCGATCTGCATGATTATTGTGACTGAAGG AAAACTTCGCTTTCACTTTCGTTATATATTTTTTTTGAAATCAAATAAATCATTAAGAATGTATCTACTGTTATTATTGTTAAC CCTGCTATTTTTGTCTCTCCTCTATAAACCGCTGTACGATGCCTACACTAAAATTAAAGAAACCCAAACACACTACAATGCTAC GGTCGATGATCGCATCGATTACATGGAGACCGTTTTAAAACATCGTCGTTTCGTGCCTCTGCATGTTTTACCAAACGTAATTTT CAACACTAATTTGGGTACGCTTAACGAAGGCGATGTCAAATGTTTATCGGTCCCAATGTACGTTGGCATTTACGATACTCCCAA TTTTGATTGTACAGCTTTATGTGACAATCCGTCGGCAGTTTATTTTTACGTAAACGAATATGACAAATTCGTTATCAACGGAGA TTTATTACCAAGAGGCGGTTATTGTACCACTAGTAGCGTGCCTCGCAATTGTAACAGGGAAACTAGCGTAATTTTGCACAGTTT AAATCAATGGTCTTGTATAGCCGAAGATCCTCGCTACTTTGCCGGTCCCCAAAATATGACCCAAGTCGCCGGTCGCCAGCATGC GGACAAAATATTACCGGGACAAGTCGATAAAAATGTGCTAACAGATCGGCTTTTAGGAACCGAAGTTGACGTTTCCAAAAACAC TTTTAGGTCGCATTGGGACGAGCTATTAGACGACGGCACGAGGCGTTTCGAAATGCGCTGCAACGCCAAAGACAATCATAACAA TCAAATGTTTCTCAACCCGTTCAATCTCATCGAGTGTCTGCCCAACGTGTGCACAAATGTCAATAACGTTCACCCCAGTGTCAG ACCCATATTCGAAACTGGCGAATGCGATTGTGGAGATTCTAACATCACCCGTCTAACACACATAATTCCCGGTGACCGCACGTC CATGTGCGCATCCGTAGTCGATGGTTTCAATCGAGATTCGATGTCGCATCAATTTAGAGTTGAATGCGTGAACATGGACATGCT GTTATCGGAATTCAGCAGTACTAAACCCCTTTGTCCCCCTGATACTTTTACCCAAAACACAGACAACGCATTTTTGTTCGAATT GCCAGGTTCTTTTCCTTTTTCGGGCAACGGTATCGACGAGCCCACTTATAGAGTGTACATGGAAACTAGGAACAGGATAAATTA TAACACAACAAGAAGTATACCAAATTAATTTATTTTTTTAATAGTAAAGTTTAAATGAAACAATCGATTTAATTCTTGCAAGTA AATTTTCCAACACTTTGAAAAATATCCTTGTTCTTTAACATACGGGAAGTTTATCTGGTGGGTGATGTCCGTTATGCTGTTTCG AAATCGGCCGGCGAAATATAATTCAATAACGAGGCGTGCCCCAAGCCGCGGGTTAGTTTTGTAAAACAGCGTTTTTACGTTCCT GATGTTGATCATGTTTTTGTCTCGCTTTATGTTTGCATATTTTTGTAATTGCTTTTCTGTGGTCGGCATGTTGTACGACCGCAA CAGGTCCTTCAAAATCTCCAATCGGTTTTGGATTGAAGGCACGCGATTAAATACATCAAACAACAAGCATTCCAGTTGATCGGC GATAGTGAGATTGATATTTACCACACAAACATATGTGTCGAACTTTTCGACCAAATTGTACAAATTTATTTTTTCATAACTATT CTTTATAACTAAATCCAGAAAGTAAACATCGAACGGAAAGTAAACGTACGTGTTAACCGAATTGTCAGATTTGTAGTTCCAAAT TGGAGATGCGCTTTTCATGTGTACATTAAACGAAAACCGTACCAGCAAAAACTCGTCGTTCACCCACGAAGAAGTGGTTTTGAA CGGAGCATTGCGATTGATTTCAAAGTAAACATCGTTCACAGAATCGATTTTAATCGCTTCGTTTACGTACGATTTGAAGAACAC GAGTCCATTATTAAATTCTTGATCGAACTTGCTACCGTCAATTTGGTTCAGCATAAATTTCATGTCAATCATTTTTAATGTTTG TTCGACTTTTATGATGTCGTCTCGAAATTCATTTGAAATGGCATTTTCGAATAAGGCTATTGGTAACGTTTCTAATGCGTTTTT TCCCTCATTGATATTGTCCAAGTAAATTTCAATGTTTAGATTGTTCGTCAGCTTGTAGGGTTTGATGGTTCGGTAATAGTCCGT GTAGCTATCGATAGCAAACGTGCCTTTGATTATGGAGAATTGATCTTCGAAAACGTTTCTAAAAGTTTTGTATAGTTTACAAAA AAAGTTTTTGTCGAACCGGTCTAAAACATCGCTGCAAAGTTGATCATTTATATTTTTTTTTGAAATATAAGGTATGGTTTTTAA ATAAAACAATTGTTGACGCAGGGATTCCATAATGAACAAGGCGGCGTTAACTTCGCGACGTCTTAATAATGCACAAAATATTTT GGCCACTATTGTGGATATCAATTCTCTTCTTAACGTAACGGACACCAGAAACAAAAGATTGTTTTACAATTTGTGCTCGCGCTA TATAAATCAAACACTATTTCAATTTACGAAAGGAAATATGGCGCTAGCCACCGTTCAGACGGTTTTGGATAGCGTCATATCTGC AGAACGTATGTTTTTCTCAAAAAGCAATGTGCTAAATATCATTGTAAACTTTCTGACCGCGCACAGCGACGGTGATAACCTACA GTGTATGATTAATTTAAAACTCCTAGACTATTTTTTACACAAGTATTATTAAATAAAAATACACATGAAAAAGTTTGATTGTTA TTTATTAAAATCTTACACATGAAATTATACAAGGTAAAATACACATGAAAAGTTTGATTATACAATTGATATTTATAAAAATCT TAATATATACATGATTGTTATTTATTAAAAATCTTCCATAATCTCAAATTTGTCATCTCCGGCCCCGAACCGCTTGTACTCGCC AACTCGCCTTTCGAAAAAATTCGTTTTGCCTTCCAACGAAATGTTGTTCATGAAGTCAAATGGATTGGTCGCGTGAAAGTACTT TTCTTGATTTAGCGCCACCAAAAGACGATCCGCAACAAACTCAATATATTGACACATTGATTTTGAGTTCATGCCCAGCATATC GCAAGGAATGGCAGTAGTGAAAAATTCCTTTTCAATTTCCACAGCTTCTTTAAACATACTCAATATTTCCGACGAAGTCAGTTT GTCATTCTCAGCAATGTAATTGTTATAGTATAAACAAGCAAAGTCGGTATGCAAACCTTCGTCTCTGCTGATTAATTCATTGCT AAACGTCAGACCCGGCATGACTCCTTTGGTTTTTAAAAAAAATATAGCCGCGAAACTGCCAGAGAAAAATACGCCCTCCACTAT AGCAAACGCGACCATACGTCGAGCCAGTCTGCTTCCTTGCGAAACTTTTGTGGGAGTTTTCTTGAAATAATTATACACTTGCTG TACGGGATATACGATGAATCTATCCCACAGAGTTTGTTTCTCTTTGTTATCGTCTTCAATCCATTTCATGGCCCAGCGCGCTTT GTTTCTCACACAATCGACATCATCGAAAGCATTGAGTAACATGTCACGTTCGGTTTCGTTTGAAATGTACTCAAAAATCAGCAA ATTGTACATTTCTGTGTGTACATTCTCAATGAGTATTTGCTGGTCGTAAAAGTAGCGGGCTTCCAGCTCTGACACAGCGTCTCG CACATATTCTATGAGGTTGATGTTGACGATGCTGTCGGCGGCAGCAAAGAAGGCCAGAACATGTTTCAAAAAGTGCCTTTCGTT GTCATTGAGCTTTGCCATGTAGTCGTCGTAATCTTTTGACAGATCGACTTCCTCGACTTTCCACATACAATCGAGTGCCTTTTT GTAAGCCTCCCATAGTTTGAAATGTTGAATGGGCAAAAGTACCTTGCGTGTGTTGGACATGTTGAAGAATAATAATAAATTGAG GCTGCGACGCCTTTTATACCAATCAGGAGTAGTACCTCTCACCTACGTCATCGCCTACTCTCGCCTTTGTGCCGGATAGCGTCC ACAGTAGTATTCGTTGATATTTTGATATTACAATATTTATAAAACGGGTCACATACGGATTTTTTTTCAGTTAAAATGGAGACT CTGTCGCCCGAGCAATTAATTGTGTACAATAAATTTATGTACAGTAATTATGTAACAAATTTGACATGTCCAACTTCAAGACTA GACACTGAAACCATTTTAAAAGTGGAAAAACTGACGAGGGGACAATCCGATAATGCGCTATGGGTTTTGCTGCGAATGGACAGA CATACGGCTTCGGGCTCGCCTTTGTCCTACAGCACATCGCCGACGTTGGCCATGACGTTTGGCCACAATCAAGAGCGTTTGGTC AAAACGAAACACGCTCTGTTGGATTTGCTCGAAAACACCATTGAAACCGCGCTAGGATGCAGCGTGGTGGAGCGCGTTCTCGAT TGTGGCATGTTTTTTTCATCAATGGGTTTGTTTTCGGCGTCGCCCGACGCTTACTTCGCCACCAACAAGGGCCAGTACATTCCG ATTGAAATAAAGTGTCCTTACACGTATAAAGATGTGACTATTGACGAAATCAGAAACGAAATGAAAACGCGCAAAAGTCGCTAT CGTGTTAAGCACACTGCGTTTTCGTTAAACAAAACCGGACCGCCGATTTTCAGTGTAGAAAAAACGGATCCTCATTACAGACAA ATGCAGAGACAAATGTATGTTATGCGTGCCCCTATTTGCATATACGTAGTAAGTTTCAAGGACCATTTCGTGGCAAGCACAGTT GAACGTGACGATGAATTCTATTTGTCAGAGTACAAAAAAGAAAAGAACATTTTTGATATGTTTGTCCGGTCAAATGGGCTTGCG AAACGCATGAAAAACCAACGAAATCGGATTGCTACTTTTCAAAATACTAATAAATTTAGAAAAGAAGATGTACTGAAGTTGACA CGAAGAGGTTTGTACTTGAAAAACGGCGAAATTATTTGCGCAATTTGCGCGACAAAGTCCGACAGCGACATTGATATATCAACG GTCCTAGATTTACACGAGCAGTGCATGGATCATAAAGACAACGAGAACATTATTGAATGTAAACATCAAAAATTTTTCAATCAT TCCACCAGGATGAAGTCACTGATTGCGGCGAACGTGGACTCTTCACATGCCAAATGGGGTTTATTTCACGAAGACGGTTTGTTT AAAACCTTTTGTTGTGACATGATCGTTACAGATTTTGTGCCAAACCACGCTACTGATTGTGATTTTGCTCAGATTAGATTATTT AGATAAAGTTAATCTTTTTATTGATAAGTTTACTATATAAATCGACTAATGTCCCATCGTTTCATCATTCTTATTGGTCTCCTT TAAAGGAATTAATAACATTTGGAATCTTTGAATTAATAACATTTGGTAAGTTTCTCTCTCTCTATAATTATATAATTAATTTAG AAGATGTAATTGTTAGTATGTTTTATTCATTTTCTTTTTATTGTTTTCAGGTAACATGTCTCTTCCTCTCAAAAATCCCTGCAG CTTATATTCTCTTTCTATTAAAGAAATAAAGAAGCGAATATTAGATGAAAATAGTTTTAAGGATTTGTCACTTCCTAAAGTTAT TATTTCCGATTTGGAAACTTTGTATGCTGAGATGCCTCCAGGATGGTATTATTGTCCGAGAAGATTAATATGTGTTGTCGATAA AGATCTTTTTGATTTTAATATTCACAAAGAAATTTGTGAGTATTACAAACAAAAAAATCTTGTTGATTTCTATGAATGTATAAA TACGTATGTTTACTGGCGGTGTTCTGATGAAATTCCTCCAGAAAACGATCTTCATTTGCAAATTGATTTGCTTCAAAATTTCAT AATGAGATTCTTTCGTTTAGGTGATGGAATGTTTATAAAACCTTGGATGGGAGGCGCACTTGAATTGTCAAATAATCGTAATAC TAAACTCATTAAATATGTAGAAGTAGATGATGATGATGATTATAAAGAAACGCCTCCTTCTTGGTTGAAGCTTGTTAAATTTAA CGATGTAGATCAAAAAATGCTGTTAAAATAAACACAAATGAAACATGTAATAATTATTAAATAAAATTTATTATATTCAAATGA GTGTATTTATTTAATTAAGTATTTTTTAATAGAAAGGTATGAAATTTTTAATCGCGCTTTTAGCCGTTGGCTTGGCAAAGGCGG CACCGTCGGGCGGTTTACCGTTGTTGGCAGAGACAGAAACTCTCATTCAAATATTCGTCAACCACCAATATTTAACTGGGTCAA AGAATGGCACAGTGTCAGGTGGTCAGGATAAAAGTTTGAAAGGCACATATTGGCGAAGAAGTAACGAAAACGGAAAACAGATTT TGCTTAGAAACGCCGCATACTGTTATTATTTGTGTATAAACGAGTGCGGTTATTATTATACAGCGAAAGAGCCCAATTCAGAAT GTTTATTGGGAGAATCTTTCACAGACTTTGCTTATACACAGATGTTCAAAGATCACGGTAAAAAGAAGGCTTATGTGGCTTTGA GCCAGTCGGGAAAGATTAGAAGACTAATGAGTAAAAAACTATCAAACAGCAAACTGTTAAACGCGTCAAAAATGACCATTATTA GAGATACTGTCGAATACACGTTTGAGTGTAACAAAATTCTCAAAACAAAATTGAAATTTGTGCCGGTAAAAACTTGTGTGAATC CACCCAAAAGGATGAACCACAAGAACGAAGCCGCCGACGATGATTATGATGATGAATCTGTGGAGACTGTTCAAAATTACTACC ACTTTGGTGAAGACGAGATCCATTTTAATCTGTTGACAACAGATCCCATAACCACAACAACGACCGAATCGTCAAAAAATTCAT CTTTAGATCGTGTAATCGACAAGCTAATAAATATTGATGTGGTGGCGGATCTACCGTCCGAACATTTTGTTATAAACAATCTAG TTGTAAATCAAATGTGTAAAATTTAACTACTTTTTCAATAAAACAAATTTTTTTAAAGTCTGTTTATTTGTTTCAATTTTAGCA TGTAACTCTATAATTGAATCCAAACATTGATCCATCAATTGTTGGTTCTTTACTTCACCCCTCTCTATGTAGTCTAACGCTTTT TCGTAACATATCAGCGATCTTTTATAATATCCAATCTTTTCAAACAAACGTGCTAACGTGAGACTTTCATTTAGGTTTTCGATA TCGTTTTCCATGTTAATTTACAGAGTAATTTGAATAAGTATTCAACACTTCGGCTAGTCCCGTTGGATTGTTGGTGTTGACTCT ATTTCCTTGAACCAAAGCCACAACGCTATAGTCGCGTATATTGGGTAAAATTGCAAACAAAACGTTGATTCGTAACGCCACGGG ATATATGTTATTTCGATATCGGGTCGCTGGACTCCATATACGCAACAAAGTTCCGTTCCTACTTAAAAAGCACCACGAATTAGT AAAAGTTTCCGCGGTCCAAACTTGCGCATTGCCATGGCGTCTTATACAATCATTATGGTTTGCCGTTATACATCTGCCCTCCTC GCCGGGATATAAACATGGCGATGAAGTTCTCGCCGACAATTGAATGTACCTATCAAATAAACTTTGATGGCTAATGTCAGTAAC GTTTTGGTCAAGCAAATGTTCGTTTCGGGGCGTGTAGGCCGTGGAAAACTTTAGTATCATAAAACCTGTATGGCTAATATCGGG ATGGTTGGTCAAGTACGGGTAGAGAATTGAGGCGTAACGTTCGTGGCTAAGTTGATTCACTCTAACCATTGCTACAACATCATC GTCTGACCGCGTCGTGTCCGATTGTGCCCAGAAAAACTTGTAGTCTAATTTTCTTAAAAACAATAACGATTGGTTAAACGGACG AATACATGCGTTGGAAACATTGGCGCTAGATTGACCAATCATTGTTTCATTAGTGGGACTGTAAACAGCAAACAAAGCGTCAAC CACGGGACAACTACAATATTTGTATTCAATGTTGGAGTTTTCATTTTTGTAATACATTAGTTTTCCTAAAGTGCGCTGACCGCT AATGGGATCTATCGAGCAGGGATCCGCCACGCAAATATCATTTAGTCTGAGTTCTTGACGATAGCGTTCGTGAAGCGCTGGATG ATCCAATCTAACGAAACCCGCTTCGCAAGGTGCGCGATGAAAAAATCGTTGATCGTAAATCACGTCTCGCACCGTCAACGGTCG GCAAAACGGCGTTTCTGTTTCTGAATTGAAATCAGACACGTAACCTTCGTTACACTGACAACGTAGCGGGCGTTCGTGTAAATC TACTATTGAGCCGTTGGGTTGACAGCCGACACTGACATTGCAATCTTCGTACATATTTAGCTGTGTAACCAAACCTGGTGTAAT GCATGAACATAACAATGAAAATCCCGTCGAACTTTCGGCCAACAACCAAATTCCTGTGTTGGGATTGCACGAACGTGCTCTGTT TCGATCGAGAGCCATGCAATACGATTCGCCCGCCTCGATGACTTTTTCGATTTCGTTGCCGTCCGTGTCGTGCATCGTAATTAC TGTACGATCGTCAAATTGCTGGCAATTTGCCAAACCCTCTCGGCAAATATCGCAATCCATATGTGTGTTGCACGGTGTAAGAGT TTTATGACATTCGTGCGAATTGCCTTCGATAATAATTTCAGAGGGAGGTTCAATTAAAGGAGTTTCAGAATTGTCAAAACGAAG TAACACGGTTTGAGCGGGTTCATAATCAGTTTTTAATAATATTATCAAAGTGGCTAGGATGATTACAATAATAATGAAACATAC GATTATTACAATCATTGTAAAACTTACATTTTATTTTTATAAAAGTTAGATTCTTCCTTTTCGTTGTCGTCGTCAAATTTGTTT ACAGGCTTACCGTTTTTATTTAATAATTTCATCATAAAACTAGGTTGGTTATCCTCAACGTAATGAAGTTGATTGTTAACCCGA ATTACCGATGGCTTGTCCGATTTGCAACATTCAAACAATTTGCTGATCGTCCCCGCACAACAGCAGTTGTATATTTTGAAAATT AGCAAGAAAGCAAACGCTAAAATTATACATACAATAATCGTTTCGGCTGTTCTACATTTGAGACCAAACCAGCTGGCGAACCAG CACATCCAACTTTCCGCCGTGGCTTGATCCGTTTCTTCAACCATGGTGTTATTGTTCATACGATGTCTCAAATCTATCAGGCGT TCGGTCATGCCTTTCAAATTGGTATGGTCGAGATCGCTGTTAGAGTTTATCGCCAACACATTTAGTTTGTCGATATCGTTTATA GCCGCCGTTAAATTAAAGGTCGAACTAATGGGCACTGTTATCATCGTCTTTAGAGCTACTGTGTTTTTAATTTTTCTCAAACTC AAAATCACCTTTTTGGTATTCATTACACAATTCTTTGTACCATCTCCTCGAATAATACCCGTGCCCGCCTTGAGGTGATACTCA AGCACGGTGCATCCAAACAAAAGATCGGTGTCCTTTTCGAGAACATACAACCAGTTGTTGTAGTCTGAAATGGGGTAAAAAATT TCACTATCGAATTTGCCCACACGAACATCGCAATCCTTTTCAAAATCAATATTTTCAACATCATTATTGAGTAGTATTTTTATG TCGCACAATTTGGCTTGGTTAGATTCGTATATGATTTGCGGTTTGGAGCAAAACATTCTGTCGTGTAAAGTTTGACAATACGGA CTATCATCTAAACGCACATAGTTGCGGCGATCTTTTGACAATCCAATGTATTTGCTGTTGGGCAAAACTATGGCACATTTGTGT TCGCCATTTTTGGCCCGACACATTGGTATAGGAATGACTTGAAACAGATTATATTCCACGTTGTTAATGAGGGGAATTTCGACA ATAAAAATAATTTTTCTCATGTTAGTAATGAAAACGTGGCTTTTAACAAAGTTGTCTATCAAAATGTTCATACCGTTCATGTCA GATGAAACGGGCCACGCTAAGTTTGCGGGCAAATGTATATTTATAATTTCGTTAAGCAATCGTTTGGGCGTTAGAACTAAAGAA TTTAAATGGTTTTGTTTTGCATCGTCCACCGACTTTTCCAAGTTTTCATACAAAAATTCAATTTGATTTAGCTGCTCTTGAATC AAATCGAACTTGGCCACGATATAACTGCAATATTCTGATCGTTTCTCATCGATGCATTTTTTATGTTCTTCGAACGAAGCCATT TTTATTAATTCGTCTGTTAGCGATTTTACTTGTTCGTTAAGGGCGTTATTGTTTTTGGCAAGTTCATTGAGTCGCTCAGCGTCA TTACTGTCCATAACTCCGAAAAGATACTTGTCAACATTGCCCACAAAATTGAACAGTCCTCTTTTTTTACGAGTGTGTAGACTC AAATCTTTGTGATCTTCAAAACTGCCAGCTTTTTGAATTTTCGAATCCAGAGTATTATGATTGTTAACCAAATCTTTGATGCGT TTCATAATGATATTTTTTATGCCCATACTAACTAGATTGGATTGAACGCAACTACTAGACGCGTTTGTGGCGGTTTCGATTTCG CTCAACAACTTCAACGACTCTTCGTGTAGAGCGTTGAGTTCTTGAAAAACTTTGCTGTGATCCATTTCGATTACAAAATTCCAT ATGTTTTCTATGAATTGCATTCTGTTAGTTGGTTGGTAATAAAGTCCCGAAGTGTTAGGTAGTCGCTCTACGGTTATCAAGTTT TCAACACGAATTTCGCTCGTAACTACTAATCCTGCCATTGAGGCCGTTAATAAAACACACAAAAGTGTCGTGGTCATTTTGAAA AATATAATAGCTCGTTGATACCCTTATTAAACTTTTATTTTTGATAATTATTCACAACTCGTCAATATGCGAAACGTGTCGAAT CTATTGTTCTCGTTTTTAAATATTATCGTTTTTAAAAAAATTTGTGCTCATAATAATGAAATTAGTAAAATCGATTCGTTAGTC GAATCATGCATCGATGTCAAGTTTAGTTCTGGTGAGTGTGAAAATAAATCCCTAATGGAAAAGTTCGATAAACAAACGTTTGAC TTTGGCACCGCAAACGGCGTGAAACACTATACTTCGTGGCTATGTTTAATGAATAACATGGAATATTTTTCGCCGTACGATAAA CCTCGATTGTTCAAAATTATGGCGCGCCACAATAACGCCATTGCAAAAATCGACGGTAAAAACATAACTAATGAAATGCGCCGA GTAAGTTCCGAAATGTTTCGATGGACATCCGACACGCTGACCAGATACCACGATCTGCAAATTATCTATGATACTTTCGATTCG TTTTATAATATGTTTAACACGTTCGTTTTATGGACGGGGCCGGGCAGTTTGTACCACTTTAACACGATTCTCTACGCGTACAAA AACGTGAGACATGCGAAATGTGCCAGGAAAATTGACGAAGCTGCCAAAGCGGCGGCAAAAATTGCCCTCTATTATCCCCTGTCC ACTATGAACAAAACTGAAGTTCTCCAACAATTTTTCATCAATTACGTTTCAAAACTAAAAATGTCTGATAGAAAAATGTTTGGG GGTTTGTACAGCTACGTAAGTCAGACGAACGTTTTGCCGTTTTTGTTGACCATACAAGTGGGCTCGTACACTTTTAATTTGCAT CATTACGAAACTGACAAGTCCAGAATTGATGCTATAAAAAATGAAACAAGATTTGTGCACGAGAATTTCAAGCGTTTCTACAAA AATTTAAATGTAAATTACGTGTACTACCAAATTGTGATTAACGGTTTCATTCATCCGACCAAACGAGCCTACACCCATTTTGGT TCGATGTGGGACATTAGCACGGACAACGGTGGATACACGCACATGACACAAAAATTGCAAATAGAATTTCATGTGTATTACAAA AACAAAGATGATTCTTTGCCGTGGAATTACGGCCACGAAATGCACCACAGCATGTTATACGCCGTAGATGCGGTGAACATAATG CCCGCTTGGTATGTCGAAGGTAGCGCAAACAGGATCGGTAACCGGCCGTGTTACGAATACGATCACGAATTGTTAAAAATTTAC ACCAACAAAACTATAAAAGAAATAATCGACGCTACCTATTCGTCGCCCTTCCTTTATGGAATGGGCAGTGTGCTGGTCCAATAT TTGTACGAAAATCGACCTGCCGATTTCAGACACATGATAGAATCAAAGAATTACTCCGTTAGCGAAACTTACGAAACGGATTTT GATGTGTTCAAATTAAATTTAATCGGTAGATGTGAAGCTGTGAAGAGAAATCAAACTGAACACAAGTTTGATAGCCAGCTGGCG TACAAAAATTTAATAGACTCGAGCACGTTTGCCTCTTGTAAAAATTACATTCGATTCGATTTTGACGATATTATTTTCGTGTTA ACACCGGACCGATTGATAAAACGAAACAAAAACGGGCAGCCCATGCTCGAATATACTCAATATTTGATCGGTCAAACTCATTTT GATGAAATCAACGAGTACACCTTTGCTTGGTTCATGGCGGGATTGGTTAAAAAGGCGGTTCAGTACTTATCAGACAATGTAAAT TTTTATTACAAATATCAGTCTAGCTATACGTATGATTCGACGGTCAAATGTCAGTATATCGACGAGTCTGCCAAAGATGCCATT ATAAATATGGCGTTTAAATATAAAAACATCGCCGATATGGTCACGTTTCCCGTCGATCAAGCAAAGGAATACATACGCCAAAAA GACAAGGCGATTGAAATGTGTGAAATGTACATGCCGCCCGTACTGCTTAATACGGCCGGGCCTGCCAAAGTATTCATCGATAGT TTGGCAAGTCCCAATTTAGTGATCCCGAGAAAAGAAACATATTATATGCGCATCGATTTAAAAGGGAACACAGTAATTCATTAT GCTGCCATGTACAAAATAAATGCCTACGAAAAAATCAAACTGGCAAACAGGACAGCCGTAGATATGGCGCCTCTCAATGCCGAC GGAAAATCGGCCGAGCAATTGTACGAATATAGTTTAAAGTTTTACAAAAAGTACAACCAAAGTAATCCTTTATATTGCTTTAAA TATATGGAAGATACAGAAAGTATCACAGAAATTATTGAAGAGGAGGTGGTGGAAAAGGAATATGAAGGAAACAATACAGTTTTA TCAAACAACCCTTTATTAAGTAAAAGCACATCAGTTATAACAGAGAAAAGCATTATTATAACAGAGATTACTACAACAGAGAAA AGCCTTATTATAACAGAGAAAAACATTATTTCAACAGACAATAACTTTAGCATTACATTTAGTTTCAAAAATTGTATAATTTTC ATACTTGTATTATTAATATCATTTATAGTTATAATACTGTTAAACGCATTGGTAACTTTAATAATAACAAAAAAAATCACTAAG CAAAAACAAAAAGTGCAACAAAAAGTTGAATATAACAAAGATAAATTTTATACTAACGACGAATGTACAATTAATTTATTTGAT TAAATACTGTTAAGGAACCATCGTTTTTTATTTATATTCAAAAACAATATCTATAGTTAGTAGTAAAGGACCCGTTTTTGAATT CACAGGGGCCCATTGAGTCGTATTGGCAAGATTACGGACGTTTAGTTCGCACTCGTTTCTTTCCACATCCTCTTCGTTGATTTT GGACAACAAATAGTTGTCGTAAACTTGTCCATCGACACTGTCCTCTTGTTTGCGATGATTGAACCATAATTTATTGTACCACTT CACATCAGATACCATAATAGCCTCATTTATGTATACTGTTAAAATTGTCTTGTCTCCCATTGCTCGCGCCATTCCCTTGACCGA AATCAAATTGTGATTTTCCTTTAGCGATTTTATCTTGCTCAATATAAATGGTGTGGTTTTAGCTTCATCTTCGCGACTCGAAAA CCCATCAAAGTAGATACATTCTTTCGGCGATTGAGCGTTCACTATACTTATGTGTTCTTTTAAATATTTAAAAGTGGCCTGGAT GTAGCTGTTACTAGAGTCAATTTCCACTTTTACCGTTTTGGATTTATTGTCCTCTATTAAATATTTATATGTTATTTTGTTAAG AAGTCTGTCCGCGCTAACCGATGCATGCTCATTTTTTATGTCGTCCAAATACAGAGTAACAGGATATTTGCATAGTTTAAACAT TTTTAAATATGCGTATTATTTCCTGTGCAAAAGCCTCCGCCTCCTGGTAATGATGAAATTTTATTCTTGTCGGGGTAATATCTA CGCGCGTACCAAACTTAGCTTCTGCCAAATTTGCACAGATTACGCGTGCTTCGCTCGGATCATCACTTACTCTGTACGCTAAAA TCCTGCATTCCTTAGTGATCTCACTGATTTTTGTGTAAAATCTAATATAATTTAACTCTTTCACAATATAAACATAATTTTTTA CCTTTGACTGAAGTTGTTTTATTTTTGTGTCTTTTCTTCGTATAGTATTCTTTAATTTTTCTGTCGATATTTCAAACTCGTGCT TGTCGCGTTTGTTTTTTTCACACATTTTTTGGTATGCTTGTTTTAAAAGCTCAAGTGCACGAGCAATTTTTTTCAAGTCTTTAA CAGTAACAAAACGAAACATTTCACCACTTTCAATATTAGCAGCGGTCAAACTACGGACTAGACTTTTGTTTCGTAGAGTAGACA TGTTTCGCGACGGTCGAACACCGAATGAAATTTGAAAGGCGAACGCGAACGTCGTCATATTTATCATCTGACGACCACGCAAAG ACACGCGATAGCTATTCCTGGAAACGAGGAAAAAAAAATACAAACATGGTAAAAACAACATTTATTATGCGTAAATCATTTTTA ACAAATTTTTAAACTGATTCATAATTGTGTAGGTGACAAACTCAATAATCATATTAGTCATGTAATACTCATTGTAATCAACAT TGGCCGCCTTTGTTTTGAAAATATTCTTGCTGTTTTTTAAATTGATTACGTAATCGGTGTACCAAACGGCCTTCCGGATAGGTG TGATCGGTTGATGACGAATATTATGTCGCAATTCTAGTATGTTTTTGCGATACAACGGATCATTGATGACAGTTTTGATCGCTT CCGTTAACTGGTTGGAGTCCACGGTGGCGGTGTCGAGTGCCAGCCCAATGCCCAATTCTACATACTTGTCGGTGTTAAACGACT GATCGCCCATCATCGGCAAACCTACCATCGGTACACCGGCGTCGATAGCTTCGTCCGTGGATTGAACCCCTCCTTGTGTCACAA ACGCTACAACATTTTTATGTTTTAGCACTTCCGGTTGGTTGAACCAAGTTTGCACCAAAACGTTGTAAGGTAATTGAGAGTTAA GTTCTTCGTCGTCCGTTTCAAACTTGAATAAAATTTTGTAGGGTAGCGCTTTAAAAGTTTGTAATAGCATATATTTAAAATCAG CATCGGTGTCTTTGGTGTTTATGCTCGAGCCGAAACTAACGTAAACCGCTCCTTGAGTGGCGCCGTCCAAGTAACGCTTCATGA AATCGTCCAGCGGCACGGGCTCGTTTCTATGCAAATGAATTCCACCCAAGTATTGAACACTAGGCGGAACCGGCCTGTTATTGT CAAAAACAGAGTGTGTATTAACAAATAACATCTGGACACGATTGCGCAGTTCCTTGATAGACGGCGATTTTCGACCGAATTGCG AGCGTATTAATTTATTCTGCTCGTCCACCAATTTTGAAAACTCATTTTGTAGCGTCAACTCCATGTAAATTTCGTTGATAGTTT CCCATACCGTTAAATCCCTGAACCGATCGCGCCACATGTTCGGATAGTATTTCGGGTGGCGGCTAACTGCACCCATAGTTTCAA AATTTTCTGCCAGTCCGTAGCCCGATGAAATTTGAATTACGGGCAGGTCACCGAACAGATGAGAAAATATTAGCGAGTAGTCCA TAAAAGCCTCGCAAATTAGCAAATCGAAATGCTCATTCTTTCGATTATTGATTAGCCTCTTGACGGCCGGCAAGTCAAATTGAT CTCTAATCATGCGCACTAAACCCATGTAGTTGTGCGCCGTGACGGTAGTACTGTCCGATATTATTCCCCTTTTTCGGAATACGC TAGATTGTTTAACCAGGTTTTTAAAGTAATTTTCGGCAAGGGTGGCATCGACTTCTGTCACATTTCGGGTAGCGTAATTGACTT TGGTAGTGGGTTTTATCACGACAATTTCGTGGCCTCTTTCCGCCAAAGCTTGTATGTAAACTTTGAACACACTCTGGTGGCTGT AGGCGGGTGTTGGTAAAACTGCGAGAATTCTCGCTCCATTTACTGCAGAAATGGCACACAAAAATAGAATATGGAAGTGCATGA CGAACAATATTCGGAATAATTTGTGTCAGTAGGCCAACGGTTTATATACTTTTATTGTGTTTCAACGAAAGTGATTCTGGAATG TTGGTCATTTTATTAAAATTATAATTTAGCTCGTTAATCTGTATAGTTTCCAGTTGCTCCTTTTCGTTGCTCTTTTTGCGTTTA CAACACATTGAATATTTGTAAAATTTAATTTTTATCAAAAGAACCGAAATTAGCACTAATAATATCAAAACGATTTTTGTATAA TTAACATCGTTTACTTCGTTTTTCTGAATGTCGGTGAGTTCATCGACAATAATATCGAGAATTTTATCTAGCTCGTCTTGCTCA CTGCCAACGGTTACGTTGATGAAATCGTCCGAACTGTTTTCGCTGTACGTAGTACTGATAAAAATAGATATGATAAAGAAAATC TGAGTAATCGTCATATTTAATTTTTTTCTTAGTCACTACTTGATATTTCCAGAGTCAACATCATGTCTCGGCGTTTCGCGATAT ACACCAGCGAAAAGGCGAAGATGGTTTGGGACTCGGTAGCATTCAATAATAGTCGCCAATTTGCCTTTTTCGATGGCACACACT GGTATCATCCCCAAAATCATTTTGCAGACTTTGATGAGTTTTTCAACTACTTGAATGAAAACAATATCAAAGATGTGCATGTAA AAGCGCTCGAGGACAACGGAGGACGCGAGTGGGTTATCGATGTGGATTTCATCGAAACTGGAAAAATATTGGAGTTTAAAATTG AAACTGCCAAAAAGATTTTCATCAATTTTTACAAGGAAAACATTGCACGGATAATGCACTCCGGGAATCGAGGACTACATGTCT GGTTGCGCATAGATAGATTTTTAATGTCGTCAAAGAAAAGTTTGCGCACCAGCTACTACTCGATATTTGTGCAACCCGAAACTG TGATTTTAGACGAAATCGTGCCCGGTAGTTTCATTCATGCTGTGAAAACCGCAGTTGAAGAAGAAACCGTTGCTCAAAAGATCG AAGAATATTTTAAGGTGAAAACTTTGGAGCAAAGAATATTAGCCGTTTGGCCCCAAGTGGACTCACACGTGTTTTGTAACTTAA ACCAAATTCGTGCTCCGTTTAGTTTTAATTCTAAGGGTCGTGATTTCTCCAAACAATTGTACTAGTAATGTTAATAAAGATGTT AAGCAAAATATTTTCGTTTGTTTTCAATAATAAAAATGACGAGGAGAACATCGAACATGAAGAGGAAGACACCGATCGGCCGCG CCGTCTGCCCGCCGTAGGTTTTTCGTATCTGTTTCAGAAAAAAAATTTCATTTTCGATGAAAACATATCGTTTTTATTACGATA CTTGTATGACAAAGACGAAGTTTGGATTTTGTATTTCGATCTGTCCGACGGGGTGGGTCTGCCAGAAGACGCCCGTGACTCTAT TAGTTATCAGAATATCAAAACTGTCAATGAACTTTTGCCCAAACAGTCTTCGCAAATTAGCAGAGTGGAATGTATTAACAAGCA TGGCATGTTGGAGGCGCTAGAATCGATTAGCTTTAAATCCAAGGCACAATTAGTGACAAAGCTGTTGGATATGTTTGCGGAATT GGAATCGAAATCGACGCCGCTATCTAAAATGGACCATAAATTTGACGTCCTATTAAAGGCTATACAAGAAGTCAAAAATGACAA TGCCAATTTGTTTAAAATACAATTGGATCGATGTCAAGATTTCGAGCGCAAAATAACAGAACTGGACAAAAAGATTAGCTTGTA TGAAAATATCGATCATCTTTACGAGCGGCTGCGTGAACGGCACAAAGCGACGGCATCGGACAGACACATGTTTCTAGATGACAA TAACGAAATGACCATTAAGCTACCAAAAGATGTATCGAAACATCCTCGAATAGCAGTGTTTATGAAACCCTCACAAGCTGGAAC AAAAGTTGCATTCGTCTCTGGCCAAAAGAAGTATTTGCAAAAAGGGAAACGAAAATTTCAAGATATGGAGTTGGTGTACGACGG GGTTCATCCGAATCCCCAGATGGCTGTAAATTGTATAGCCGAGGAACTAGACTTTAAAAATTTTGATTATATTAAAAAGGCTCG TTTGTATTATTTAAACTGTAACTTGGAAACGGCAAAGTCGTTTATAAAAGAAAATTTGTAATAAATAAATTTGAATATACACTT TTGTTATCAGTTACGCCTCCGTTTTTTATCTATTCCTCCCTATAAAAGAACAGATTTTCAAAATAAAATCACAGTACAGCAACA TGTTTGTGGTTAAACGTAACGGTCGTAAACAACCCGTCCTCATGGACAAAATCACTAAAAGGCTTGAAAAGTTATGTTTTGGAC TAAACATCAAAGCCGTTTTAGTGGCGATGGAAGTGGTCAATTTTATTTACGAAAATGTAACCACCGAAGAATTGGACATGCAAG CGGCAAAGGTTGCTGCAAACAAATCATATTTGCACAATGATTACGCCTTATTGGCAGGCAGAATCATGATTAGCAACCTGTCGA AAAAAATCAAGTCTGATTTTTCTGAAGTTATCGAAAGATTGTACAAATACAAATTGGTTACTAAATTTTTGTACGATGTAGTAT GTGCCAACAAAAAAGTTCTCAACGAATGTATACTTTACGAGAACGATTACGATTACAAGTACTTTGGTTTTAAAACCTTAGAAA ACGGGTACTTGTTTAAAATCGATGAGCAGACCGCTGAATTACCGCAGCAAATGCTGATGAGAGTTTCGCTCGGAATTCACGGCG ACAACATTGAAGATGCCATTGAAACATACAAACTGCTGTCTGAAAAAAAATTCATTCACGCCAGTCCCACACTATTTGCGGCCG GAACAAACTTGCCCCAATTATCATCGTGTTTTTTGGTGAGCATGAAAGAAGACAGCATAGCCGGCATATACAACACGCTAACCA CTTGCGCGTTAATTTCGAAACATGGCGGCGGAATAGGACTGAACGTACACGAAATTCGCGCTCGTAACAGTCCCATCAAAGCGA CCAACGGAACTTCGAGCGGACTAGAGTCTATGCTTCGCGTATTCAATAATATGGTACGACACGTTGATCAGGGCGGCAAAAGAA AAGGCGCCATGGCAATTTACTTGGAACCGTGGCACGCCGACATTTATGATTTTTTAAATCTAAAAAGAAACATGGGCGCCGAAG ACAAAAAGGCCCGTGATCTTTTGTACGCTCTATGGGTACCTGATTTATTTATGAAACGTGTAGAAAATGGCGAAATGTGGTCAC TCATGTGTCCCGACGCTTGCAAGGGATTGGATCGAATTTATGGAAAAGAATTTGAAGAGTTATATTCGCGTTATGAATCAGAAA AGAAATACGTGAAGCAAGTGAACGCGCGCGATCTTTTCAGATTCATAATTGAAACCCAAGTCGAAACCGGTACACCGTACATGC TGTACAAAGATGCTTGTAACGGTAAAAGTAATCAAAAAAACTTGGGCACAATAAAATGTAGTAATCTTTGTGCCGAAATAGTAC AATTCAACAGTGGTGACGAAACAGGCGTTTGCAATTTGGCATCTATTTCGGTCAACAAGTTTGTTTGCGATAATTTCGAGTACG ATTTCAAGTCGTTAAAAAAGGTGACCAAAGTGATTGTGAAAAACCTCAACAAAATAATCGATGTCAATTTTTATCCAGTAAATT GTGCCCGCGATTCGAATTTCAAACATCGACCTATCGGCGTGGGTATTCAGGGGCTGGCCGATACTTTTGTAATGCTCAGACTGC CGTATGAAAGTGACAAGGCCAAGTTGCTAAACAAACAAATAGCAGAAACCATTTATTATGCCGCGCTGGAAGCTAGCTGCGAGC TCGCAAAAACTGACGGGCCATATTCGTCATACAAAGGCAGTCCGGCCAGCGAAGGTTTGTTACAATACGATTTGTGGAATGTGA CTCCTACAAAACTTTGGGACTGGAAAGTTTTGAAAGAGAACATTAAATTGTACGGACTCCGCAATTCTTTGCTGGTAGCGTACA TGCCTACCGCTACGACGGCTCAAATACTCGGCAACAACGAATCTTTCGAACCTTTCACTAACAACTTGTATGTGCGCCGAGTGC TGGCGGGCGATTTTCAAGTTGTAAACCAATATTTGGTGGATGATTTGTTGCGTCTCAATTTGTATAATGATAATATGCTCAACA AAATTATCGCCAACAACGGCAGTATTCAAGCCATCGAAGGTATACCTGCCGATATCAAAGAGTTGTATAAAACCGTGTGGGAAA TGAAGCAAAAAAATTTGATTGACATGGCCGCCGATCGCGCAGCGTTCATAGACCAGAGTCAATCATTTAATGTTTTCGTTGCCA ATCCCACTTATTCTCTGATGACATCGATTCATACTTACGCTTGGAAAAAAGGATTGAAAACGGGAATGTATTATTTGCGCACCA AGCCTGCCGCGGATCCTATCAAGTTTACTGTGGACGCCACATGTTCTAAAGTGAACGGTCAATGTATGGGATGTGATGCTTAAT AAAATTTGTAATAAAAATTTTCATTGTTTTATTTTTTTTATTGTAAAAATGAAGAAATATTTTTCGTGTCTTTCTTCATTTTTA CAAGCAAATAAGTATTTTTCTCCTTTCGTAAAACATTGTGAAAAATCAAATATA 

1-19. (canceled)
 20. A biopesticidal composition for use in controlling insect populations, the composition comprising a nucleopolyhedrovirus (NPV) having a genome sequence with at least 85% sequence identity to SEQ ID NO:
 2. 21. A biopesticidal composition as claimed in claim 20, in which the NPV has a polyhedrin gene with more than 93% sequence identity to SEQ ID NO:
 1. 22. A biopesticidal composition as claimed in claim 20, in which the NPV is an isolate or genotype of an NPV whose genome sequence is represented by SEQ ID NO:
 2. 23. A biopesticidal composition as claimed in claim 20, in which the NPV has a virulence host range comprising the Grapholitini tribe of the lepidopteran family, Tortricidae.
 24. A biopesticidal composition as claimed in claim 23, wherein the host range comprises Cryptophlebia peltastica, Thaumatotibia leucotreta, Cydia pomonella, Grapholita molesta, and Thaumatotibia batracopa.
 25. A biopesticidal composition as claimed in claim 20, wherein the insects are selected from the tribe Grapholitini.
 26. A biopesticidal composition as claimed in claim 25, wherein the insects are selected from the larvae of Cryptophlebia peltastica, Thaumatotibia (Cryptophlebia) leucotreta, Cydia pomonella Grapholita molesta and Thaumatotibia batracopa.
 27. A biopesticidal composition as claimed in claim 20, comprising the NPV and one or more additional biopesticide.
 28. A biopesticidal composition as claimed in claim 27, wherein the additional biopesticide is a Cryptophlebia leucotreta granulovirus, a Cydia pomonella granulovirus, a Cryptophlebia batracopa granulovirus or a Grapholita molesta granulovirus.
 29. A biopesticidal composition as claimed in claim 20, wherein the NPV genome sequence contains only one recognition site for the restriction enzyme Sma1.
 30. A biopesticidal composition as claimed in claim 20, comprising one or more agronomically acceptable adjuvants and/or diluents.
 31. A biopesticidal composition as claimed in claim 20, further comprising a feeding stimulant, a mineral oil and a UV protectant.
 32. A method of controlling insect populations, the method comprising applying to the insects or their locus an insecticidally effective amount of a biopesticidal composition comprising a nucleopolyhedrovirus (NPV) having a genome sequence with at least 85% sequence identity to SEQ ID NO:
 2. 33. A method as claimed in claim 32, which comprises simultaneously or sequentially applying, in addition to the biopesticidal composition, at least one additional biopesticide to the insects or their locus.
 34. A method of treating or preventing insect infestations on plants or fruit, the method comprising applying an insecticidally effective amount of a biopesticidal composition comprising a nucleopolyhedrovirus (NPV) having a genome sequence with at least 85% sequence identity to SEQ ID NO: 2 to the plants or fruit. 